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001-es BibID:BIBFORM024305
Első szerző:Saukkonen, T.
Cím:Increased frequency of IgM antibodies to cow's milk proteins in Hungarian children with newly diagnosed insulin-dependent diabetes mellitus / T. Saukkonen, E. Savilahti, L. Madácsy, A. Arató, A. Körner, L. Barkai, A. Sarnesto, H. K. Åkerblom
Dátum:1996
Megjegyzések:We investigated the association between serum antibodies to cow's milk proteins and insulin-dependent diabetes mellitus (IDDM) in Hungarian children. Forty-eight children 1.0-17.1 years of age with newly diagnosed IDDM and 74 control children 1.0-16.0 years of age were studied for serum IgG, IgA and IgM antibodies to cow's milk, ?-lactoglobulin, bovine serum albumin and ovalbumin by enzyme-linked immunosorbent assays. The specificity of IgM antibodies to ?-lactoglobulin and bovine serum albumin was controlled by Western blot. The levels of IgG and IgA antibodies to cow's milk proteins were similar in children with and without IDDM, with the exception of slightly increased levels of IgA antibodies to ?-lactoglobulin in diabetic children (P = 0.05). The levels of IgM antibodies to cow's milk were significantly higher in IDDM patients than in control children (P = 0.0002). Children with IDDM more often had IgM antibodies to ?-lactoglobulin (46.3% vs 18.8%; P = 0.002) and bovine serum albumin (87.8% vs 49.3%, P < 0.0001) than control children. Neither the levels of IgG or IgA antibodies to ovalbumin nor the frequency of IgM antibodies to ovalbumin differed between diabetic and control children. Conclusion: In Hungarian children, clinical manifestation of IDDM is often associated with IgM antibody response to cow's milk protein and bovine serum albumin, ?-lactoglobulin and bovine serum albumin, indicating a loss of immunological tolerance to these proteins. IgG and IgA antibodies to cow's milk proteins, associated with an early introduction of cow's milk in diet, seem to play a minor role in the development of childhood IDDM in Hungary.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Serum Albumin
ovalbumin
Milk Proteins
Lactoglobulins
Infant
Immunoglobulin M
Immunoglobulin A
Hungary
Humans
Diabetes Mellitus, Type 1
Child, Preschool
Child
Adolescent
priority journal
milk
major clinical study
insulin dependent diabetes mellitus
immunological tolerance
immunoglobulin blood level
immunoblotting
human
enzyme linked immunosorbent assay
ARTICLE
antibody titer
immunoglobulin M antibody
immunoglobulin A antibody
beta lactoglobulin
IDDM
Cow's milk antibodies
Bovine serum albumin antibodies
?-Lactoglobulin antibodies
albumin
ABSORPTION
Permeability
childhood
RISK
FINNISH CHILDREN
BETA-LACTOGLOBULIN
cow's milk antibodies
beta-lactoglobulin antibodies
Megjelenés:European Journal of Pediatrics. - 155 : 10 (1996), p. 885-889. -
További szerzők:Savilahti, Erkki Madácsy László (Szeged) Arató András Körner Anna Barkai László (1958-) (gyermekgyógyász) Sarnesto, Annikki Åkerblom, H. K.
Internet cím:DOI
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