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001-es BibID:	bibEBI00026273
035-os BibID:	(cikkazonosító)E3050 (WoS)000581708900001 (Scopus)85108175368
Első szerző:	Bagoly Zsuzsa (orvos)
Cím:	Uninterrupted Dabigatran Administration Provides Greater Inhibition against Intracardiac Activation of Hemostasis as Compared to Vitamin K Antagonists during Cryoballoon Catheter Ablation of Atrial Fibrillation / Zsuzsa Bagoly, Orsolya Hajas, Réka Urbancsek, Alexandra Kiss, Edit Fiak, Ferenc Sarkady, Noémi Klára Tóth, Rita Orbán-Kálmándi, Kitti Bernadett Kovács, László Nagy, Attila Nagy, János Kappelmayer, László Csiba, Zoltán Csanádi
Dátum:	2020
ISSN:	2077-0383
Megjegyzések:	Background. Cerebral thromboembolism is a rare but feared complication of transcatheter ablation in patients with atrial fibrillation (AF). Here, we aimed to test which pre-procedural anticoagulation strategy results in less intracardiac activation of hemostasis during ablation. Patients and methods. In this observational study, 54 paroxysmal / persistent AF patients undergoing cryoballoon ablation were grouped according to their periprocedural anticoagulation strategy: no anticoagulation (oral anticoagulation (OAC) free; n = 24), uninterrupted vitamin K antagonists (VKA) ( n = 11), uninterrupted dabigatran ( n = 17). Blood was drawn from the left atrium before and immediately after the ablation procedure. Cryoablations were performed according to standard protocols, during which heparin was administered. Heparin-insensitive markers of hemostasis and endothelial damage were tested from intracardiac samples: D-dimer, quantitative fibrin monomer (FM), plasmin-antiplasmin complex (PAP), von Willebrand factor (VWF) antigen, chromogenic factor VIII (FVIII) activity. Results. D-dimer increased significantly in all groups post-ablation, with lowest levels in the dabigatran group (median [interquartile range]: 0.27 [0.36] vs. 1.09 [1.30] and 0.74 [0.26] mg / L in OAC free and uninterrupted VKA groups, respectively, p < 0.001 ). PAP levels were parallel to this observation. Post-ablation FM levels were elevated in OAC free ( 26.34 [30.04] mg / L ) and VKA groups (10.12 [16.01] mg / L), but remained below cut-o in all patients on dabigatran ( 3.98 [2.0] mg / L; p < 0.001). VWF antigen and FVIII activity increased similarly post-ablation in all groups, suggesting comparable procedure-related endothelial damage. Conclusion. Dabigatran provides greater inhibition against intracardiac activation of hemostasis as compared to VKAs during cryoballoon catheter ablation.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk atrial fibrillation cryoballoon ablation; dabigatran vitamin K antagonists
Megjelenés:	Journal of Clinical Medicine. - 9 : 9 (2020), p. 1-13. -
További szerzők:	Hajas Orsolya (1987-) Urbancsek Réka (1991-) (általános orvos) Kiss Alexandra (1987-) (általános orvos) Fiák Edit Sarkady Ferenc (1982-) (laboratóriumi analitikus) Tóth Noémi Klára Orbán-Kálmándi Rita Angéla (1993-) (klinikai laboratóriumi kutató) Kovács Kitti Bernadett (1985-) (neurológus) Nagy László Tibor (1969-) (belgyógyász, kardiológus) Nagy Attila Csaba (1981-) (megelőző orvostan és népegészségtan szakorvos, epidemiológus) Kappelmayer János (1960-) (laboratóriumi szakorvos) Csiba László (1952-) (neurológus, pszichiáter) Csanádi Zoltán (1960-) (kardiológus)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00043 GINOP MTA-DE MTA K109712 OTKA K120042 OTKA FK128582 OTKA
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001-es BibID:	BIBFORM098776
035-os BibID:	(WoS)000671324200001 (cikkazonosító)2873
Első szerző:	Santoso, Cornelia Melinda Adi
Cím:	Association between Oral Hygiene and Metabolic Syndrome : a Systematic Review and Meta-Analysis / Cornelia Melinda Adi Santoso, Fera Ketti, Taufan Bramantoro, Judit Zsuga, Attila Nagy
Dátum:	2021
ISSN:	2077-0383
Megjegyzések:	Emerging evidence has linked poor oral hygiene to metabolic syndrome (MetS), but previously, no summary of evidence has been conducted on the topic. This systematic review and meta-analysis aims to evaluate the associations of oral hygiene status and care with MetS. A systematic search of the PubMed and Web of Science databases from inception to 17 March 2021, and examination of reference lists was conducted to identify eligible observational studies. A random-effects model was applied to pool the effects of oral hygiene status and care on MetS. Thirteen studies met the inclusion criteria and had sufficient methodological quality. Good oral hygiene status (OR = 0.30 (0.13?0.66); I2 = 91%), frequent tooth brushing (OR = 0.68 (0.58?0.80); I2 = 89%), and frequent interdental cleaning (OR = 0.89 (0.81?0.99); I2 = 27%) were associated with a lower risk of MetS. Only one study examined the association between dental visits and MetS (OR = 1.10 (0.77?1.55)). Our findings suggested that there might be inverse associations of oral hygiene status, tooth-brushing frequency, and interdental cleaning with MetS. However, substantial heterogeneity for tooth-brushing frequency and inconsistent results for oral hygiene status in subgroup analyses were observed. There was insufficient evidence for the association between dental visits and MetS. Further longitudinal studies are needed to investigate these associations.
Tárgyszavak:	Természettudományok Környezettudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk oral hygiene dental plaque oral bacteria tooth brushing interdental cleaning dental visit metabolic syndrome
Megjelenés:	Journal of Clinical Medicine. - 10 : 13 (2021), p. 1-16. -
További szerzők:	Ketti, Fera Bramantoro, Taufan Zsuga Judit (1973-) (neurológus, pszichoterapeuta, egészségügyi szakmanager) Nagy Attila Csaba (1981-) (megelőző orvostan és népegészségtan szakorvos, epidemiológus)
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