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001-es BibID:	BIBFORM040623
Első szerző:	Szűcs Péter (kutatóorvos)
Cím:	Axon diversity of lamina I local-circuit neurons in the lumbar spinal / Szucs Peter, Luz Liliana, Pinho Raquel, Aguiar Paulo, Antal Zsofia, Tiong Sheena, Todd Andrew J., Safronov Boris
Dátum:	2013
Megjegyzések:	Spinal lamina I is a key area for relaying and integrating information from nociceptive primary afferents with various other sources of inputs. While lamina I projection neurons have been intensively studied, much less attention has been given to local-circuit neurons (LCNs), which form the majority of the lamina I neuronal population. In this work the infrared light-emitting diode (IR-LED) oblique illumination technique was used to visualize and label LCNs, allowing reconstruction and analysis of their dendritic and extensive axonal trees. We show that the majority of lamina I neurons with locally branching axons fall into the multipolar (with ventrally protruding dendrites) and flattened (dendrites limited to lamina I) somatodendritic categories. Analysis of their axons revealed that the initial myelinated part gives rise to several unmyelinated small-diameter branches that have a high number of densely packed large varicosities and an extensive rostrocaudal (2-3 segments), mediolateral and dorsoventral (reaching laminae III-IV) distribution. The extent of the axon and the occasional presence of long solitary branches suggest that LCNs may also form short and long propriospinal connections. We also found that the distribution of axon varicosities and terminal field locations show substantial heterogeneity and that a substantial portion of LCNs is inhibitory. Our observations indicate that LCNs of lamina I form intersegmental as well as interlaminar connections and may govern large numbers of neurons, providing anatomical substrate for rostrocaudal "processing units" in the dorsal horn.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Comparative Neurology. - 521 : 12 (2013), p. 2719-2741. -
További szerzők:	Luz, Liliana L. Pinho, Raquel Aguiar, Paulo Antal Zsófia (1985-) (orvos) Tiong, Sheena Todd, Andrew J. Safronov, Boris V.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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