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1.

001-es BibID:BIBFORM070620
Első szerző:Asztalos László (aneszteziológus)
Cím:Reversal of Vecuronium-induced Neuromuscular Blockade with Low-dose Sugammadex at Train-of-four Count of Four : a Randomized Controlled Trial / László Asztalos, Zoltán Szabó-Maák, András Gajdos, Réka Nemes, Adrienn Pongrácz, Szabolcs Lengyel, Béla Fülesdi, Edömér Tassonyi
Dátum:2017
Megjegyzések:Background: Rocuronium-induced neuromuscular block that spontaneously recovered to a train-of-four count of four can bereversed with sugammadex 0.5 or 1.0 mg/kg. We investigated whether these doses of sugammadex can also reverse vecuroniumat a similar level of block.Methods: Sixty-five patients were randomly assigned, and 64 were analyzed in this controlled, superiority study. Participantsreceived general anesthesia with propofol, sevoflurane, fentanyl, and vecuronium. Measurement of neuromuscular functionwas performed with acceleromyography (TOF-Watch-SX, Organon Teknika B.V., The Netherlands ). Once the block recoveredspontaneously to four twitches in response to train-of-four stimulation, patients were randomly assigned to receivesugammadex 0.5, 1.0, or 2.0 mg/kg; neostigmine 0.05 mg/kg; or placebo. Time from study drug injection to normalizedtrain-of-four ratio 0.9 and the incidence of incomplete reversal within 30 min were the primary outcome variables. Secondaryoutcome was the incidence of reparalysis (normalized train-of-four ratio less than 0.9).Results: Sugammadex, in doses of 1.0 and 2.0 mg/kg, reversed a threshold train-of-four count of four to normalized train-offourratio of 0.9 or higher in all patients in 4.4 ? 2.3 min (mean ? SD) and 2.6 ? 1.6 min, respectively. Sugammadex 0.5 mg/kgreversed the block in 6.8 ? 4.1 min in 70% of patients (P < 0.0001 vs. 1.0 and 2.0 mg/kg), whereas neostigmine producedreversal in 11.3 ? 9.7 min in 77% of patients (P > 0.05 vs. sugammadex 0.5 mg/kg). The overall frequency of reparalysis was18.7%, but this incidence varied from group to group.Conclusions: Sugammadex 1.0 mg/kg, unlike 0.5 mg/kg, properly reversed a threshold train-of-four count of four vecuroniuminducedblock but did not prevent reparalysis.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
neuromuscular block
Megjelenés:Anesthesiology. - 127 : 3 (2017), p. 441-449. -
További szerzők:Szabó-Maák Zoltán (1984-) (aneszteziológus, intenzív terápiás szakorvos) Gajdos András Nemes Réka (1985-) (aneszteziológus, intenzív terápiás szakorvos) Pongrácz Adrienn (1971-) (aneszteziológus, intenzív terápiás szakorvos) Lengyel Szabolcs (1971-) (biológus) Fülesdi Béla (1961-) (aneszteziológus) Tassonyi Edömér (1940-2022) (aneszteziológus)
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2.

001-es BibID:BIBFORM096675
035-os BibID:(WoS)000695249600011 (Scopus)85115605217
Első szerző:Nemes Réka (aneszteziológus, intenzív terápiás szakorvos)
Cím:Ipsilateral and Simultaneous Comparison of Responses from Acceleromyography- and Electromyography-based Neuromuscular Monitors / Nemes Réka, Lengyel Szabolcs, Nagy György, Hampton David R., Gray Martyn, Renew J. Ross, Tassonyi Edömér, Fülesdi Béla, Brull Sorin J.
Dátum:2021
ISSN:0003-3022
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Anesthesiology. - 135 : 4 (2021), p. 597-611. -
További szerzők:Lengyel Szabolcs (1971-) (biológus) Nagy György (1986-) (aneszteziológus, intenzív terápiás szakorvos) Hampton, David R. Gray, Martyn Renew, J. Ross Tassonyi Edömér (1940-2022) (aneszteziológus) Fülesdi Béla (1961-) (aneszteziológus) Brull, Sorin J.
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3.

001-es BibID:BIBFORM076718
Első szerző:Nemes Réka (aneszteziológus, intenzív terápiás szakorvos)
Cím:Performance Assessment of a New Electromyography-based Neuromuscular Monitor and Subjective Discomfort in Unmedicated Volunteers / Nemes Reka, Dioszeghy Boglarka, Pongracz Adrienn, Tassonyi Edomer, Fulesdi Bela
Dátum:2018
ISSN:2155-6148 2155-6148
Megjegyzések:Objective: The aim of this prospective, unblinded, randomized study was to provide performance data of the prototype of new electromyography-based neuromuscular monitor, the NEAT device (Acacia Designs BV, Amsterdam, the Netherlands) and assess the subjective discomfort associated with neurostimulation in unmedicated healthy volunteers. Methods: The study enrolled ten male and ten female volunteers. Based on a priori randomization the ulnar nerve of the left or right arms was stimulated in 1 Hz single twitch and train-of-four modes. Stimulating current intensity was increased from 10 mA to 60 mA in 10 mA steps. Electromyography recordings were performed at the abductor digiti minimi and adductor pollicis muscles via surface electrodes. The volunteers were asked to rate the discomfort in association with neurostimulation on a 0-10 visual analogue scale. Results: The overall train-of-four ratio was 1.02 (0.98-1.06) {median and (interquartile range)}. The abductor digiti minimi muscle required lower stimulating current intensity to evoke maximal stimulation, than the adductor pollicis (30 vs. 50 mA, p <0.001). The overall intracurrent variability of compound muscle action potential amplitudes was 0.42 (0.21-0.87) mV, that was unaffected by the type of muscle or the stimulating current intensity. Women reported moderately higher visual analogue scale scores than men. The largest recorded difference was 5 (3.75-6) vs. 3 (3-4), p <0.05. Conclusion: The Acacia Designs BV NEAT monitoring device was suitable to deliver neurostimulation, record and analyze the elicited muscle action potentials. The precision of stimulations was acceptable. The volunteers reported the discomfort in association with neurostimulation as tolerable. Registered at the Hungarian Office for Health Authorization and Administrative Procedures (December 30th, 2014). Identifier: 028605-010/2014/OTIG. Registered at clinicaltrials.gov (December 15th, 2015). Identifier: NCT02630576.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Neuromuscular monitoring
Electromyography
Visual analogue scoring scale
Abductor digiti minimi muscle
Adductor pollicis muscle
Megjelenés:Journal of Anesthesia and Clinical Research. - 9 : 8 (2018), p. 1-8. -
További szerzők:Diószeghy Boglárka Pongrácz Adrienn (1971-) (aneszteziológus, intenzív terápiás szakorvos) Tassonyi Edömér (1940-2022) (aneszteziológus) Fülesdi Béla (1961-) (aneszteziológus)
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4.

001-es BibID:BIBFORM068730
Első szerző:Nemes Réka (aneszteziológus, intenzív terápiás szakorvos)
Cím:Impact of reversal strategies on the incidence of postoperative residual paralysis after rocuronium relaxation without neuromuscular monitoring : a partially randomised placebo controlled trial / Réka Nemes, Béla Fülesdi, Adrienn Pongrácz, László Asztalos, Zoltán Szabó-Maák, Szabolcs Lengyel, Edömér Tassonyi
Dátum:2017
ISSN:0265-0215
Megjegyzések:BACKGROUND:Electronic neuromuscular monitoring is not widely used to determine either the reversal requirements for neuromuscular block before extubation of the trachea, or to determine if there is any subsequent postoperative residual neuromuscular block (PORNB).OBJECTIVES: To investigate the incidence of PORNB using acceleromyography after spontaneous recovery of rocuronium-induced block and to compare this with the administration of sugammadex, neostigmine or a placebo.DESIGN: Prospective, partially randomised, placebo-controlled, double-blind, four-group parallel-arm study.SETTING: Single-centre study performed between October 2013 and December 2015 in a university hospital.PATIENTS: Of the 134 eligible patients, 128 gave their consent and 125 of these completed the study.INTERVENTIONS: Patients received general anaesthesia with propofol, sevoflurane, fentanyl and rocuronium. Neuromuscular transmission was measured by acceleromyography (TOF-Watch-SX; Organon Teknika B.V., Boxtel, the Netherlands) but the anaesthetist was blind to the results. If the anaesthetist deemed pharmacological reversal to be necessary before extubation of the trachea then patients were assigned randomly to receive either sugammadex (2.0 mg kg-1), neostigmine (0.05 mg kg-1) or a placebo. In the postanaesthesia care unit, an independent anaesthetist, unaware of the treatment given, assessed the neuromuscular function using acceleromyography.MAIN OUTCOME MEASURES: The incidence of a normalised train-of-four ratio less than 0.9 on arrival in the recovery room.RESULTS: In total, 125 patients were recruited. Neuromuscular block was allowed to recover spontaneously in 50 patients, whereas the remainder received either sugammadex (27), neostigmine (26) or placebo (22). The number of cases with PORNB were one (3.7%), four (15%), 13 (26%) and 10 (45%) after sugammadex, neostigmine, spontaneous recovery and placebo, respectively. Sugammadex and neostigmine were more effective than placebo [odds ratio (OR): 0.05, 95% confidence interval (CI): 0.005 to 0.403, P = 0.005; OR: 0.22, 95% CI: 0.056 to 0.85, P = 0.028, respectively]. Sugammadex performed better than spontaneous recovery (OR: 0.11, 95% CI: 0.014 to 0.89, P = 0.039) unlike neostigmine (OR: 0.52, 95% CI: 0.15 to 1.79, P = 0.297). Yet, antagonism (pooled data) was more effective than spontaneous recovery (OR: 0.3, 95% CI: 0.1 to 0.9, P = 0.03).CONCLUSION: Although pharmacological reversal based on clinical signs was superior to spontaneous recovery it did not prevent PORNB, irrespective of the reversal agent.TRIAL REGISTRATION: The study is registered under EUDRACT number 2013-001965-17.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Electronic neuromuscular monitoring
Megjelenés:European Journal Of Anaesthesiology. - 34 : 9 (2017), p. 609-616. -
További szerzők:Fülesdi Béla (1961-) (aneszteziológus) Pongrácz Adrienn (1971-) (aneszteziológus, intenzív terápiás szakorvos) Asztalos László (1985-) (aneszteziológus) Szabó-Maák Zoltán (1984-) (aneszteziológus, intenzív terápiás szakorvos) Lengyel Szabolcs (1971-) (biológus) Tassonyi Edömér (1940-2022) (aneszteziológus)
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5.

001-es BibID:BIBFORM078888
Első szerző:Pongrácz Adrienn (aneszteziológus, intenzív terápiás szakorvos)
Cím:International survey of neuromuscular monitoring in two European countries : a questionnaire study among Hungarian and Romanian anaesthesiologists / Adrienn Pongrácz, Réka Nemes, Caius Breazu, László Asztalos, Ileana Mitre, Edömér Tassonyi, Béla Fülesdi, Calin Mitre
Dátum:2019
Megjegyzések:Background: Accumulating evidence indicates that objective neuromuscular monitoring and pharmacological reversal of neuromuscular block reduces the occurrence of residual muscle paralysis in the acute postoperative phase. However, objective neuromuscular monitoring is not a routine habit in anaesthesia. In order to change this situation, we wished to find out, as a first step to improvement, the current use of neuromuscular monitors and the custom of anaesthetists for reversal of neuromuscular block before tracheal extubation. Methods A ten-point questionnaire was available via the Surveymonkey website and the link was sent to 2202 Hungarian and Romanian anaesthetists by email. Results: Three hundred and two (13.7%) of the 2202 registered anaesthetists responded. Less than 10% of them regularly use neuromuscular monitors. They underestimated the occurrence of residual block; only 2.2% gave a correct answer. Neuromuscular monitors are available in 74% of hospitals but are scarcely used. One third of anaesthetists rarely or never use reversal; approximately 20% regularly reverse before extubation. The responders typically believe that clinical signs of residual block are reliable. Instead of monitoring, they use the "timing methods" for tracheal extubation such as time elapsed from last dose, the duration of action of relaxant, the number of top-up doses, the cumulative dose, the return of adequate respiratory tidal volume and the ability to sustain a 5 s head lift. Conclusions: We concluded that neuromuscular monitoring in these two European countries is suboptimal as is the reversal strategy. Given the fact that monitors are available in the hospitals, the mentality should be changed towards evidence based practice.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
neuromuscular blocking agents
neuromuscular monitoring
residual neuromuscular block
survey
Megjelenés:Romanian Journal of Anaesthesia and Intensive Care. - 26 : 1 (2019), p. 45-51. -
További szerzők:Nemes Réka (1985-) (aneszteziológus, intenzív terápiás szakorvos) Breazu, Caius Asztalos László (1985-) (aneszteziológus) Mitre, Ileana Tassonyi Edömér (1940-2022) (aneszteziológus) Fülesdi Béla (1961-) (aneszteziológus) Mitre, Calin
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6.

001-es BibID:BIBFORM053009
Első szerző:Pongrácz Adrienn (aneszteziológus, intenzív terápiás szakorvos)
Cím:In reply : Sugammadex after the reappearance of four twitches during train-of-four stimulation : monitoring and dose considerations / Adrienn Pongrácz, Réka Nemes, Béla Fülesdi, Edömér Tassonyi
Dátum:2014
ISSN:0003-3022
Tárgyszavak:Orvostudományok Klinikai orvostudományok szerkesztői levél
Megjelenés:Anesthesiology. - 120 : 2 (2014), p. 508-509. -
További szerzők:Nemes Réka (1985-) (aneszteziológus, intenzív terápiás szakorvos) Fülesdi Béla (1961-) (aneszteziológus) Tassonyi Edömér (1940-2022) (aneszteziológus)
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DOI
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7.

001-es BibID:BIBFORM053007
Első szerző:Pongrácz Adrienn (aneszteziológus, intenzív terápiás szakorvos)
Cím:Reversal of neuromuscular blockade with sugammadex at the reappearance of four twitches to train-of-four stimulation / Adrienn Pongrácz, Szilárd Szatmári, Réka Nemes, Béla Fülesdi, Edömér Tassonyi
Dátum:2013
ISSN:0003-3022
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Anesthesiology. - 119 : 1 (2013), p. 36-42. -
További szerzők:Szatmári Szilárd (1984-) (aneszteziológus) Nemes Réka (1985-) (aneszteziológus, intenzív terápiás szakorvos) Fülesdi Béla (1961-) (aneszteziológus) Tassonyi Edömér (1940-2022) (aneszteziológus)
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DOI
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8.

001-es BibID:BIBFORM020941
Első szerző:Sárkány Péter (aneszteziológus)
Cím:Testing rocuronium-induced neuromuscular blockade at the stapedius muscle using stapedius reflex measurements / Sárkány Péter, Tassonyi Edömér, Nemes Réka, Timkó Adrienn, Pongrácz Adrienn, Fülesdi Béla
Dátum:2011
ISSN:1588-2683
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban
Megjelenés:Acta Physiologica Hungarica. - 98 : 4 (2011), p. 472-479. -
További szerzők:Tassonyi Edömér (1940-2022) (aneszteziológus) Nemes Réka (1985-) (aneszteziológus, intenzív terápiás szakorvos) Timkó Adrienn Pongrácz Adrienn (1971-) (aneszteziológus, intenzív terápiás szakorvos) Fülesdi Béla (1961-) (aneszteziológus)
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9.

001-es BibID:BIBFORM077685
035-os BibID:(WoS)000450430400024 (Scopus)85056649292
Első szerző:Tassonyi Edömér (aneszteziológus)
Cím:Reversal of Deep Pipecuronium-Induced Neuromuscular Block With Moderate Versus Standard Dose of Sugammadex : a Randomized, Double-Blind, Noninferiority Trial / Edömér Tassonyi, László Asztalos, Zoltán Szabó-Maák, Réka Nemes, Adrienn Pongrácz, Szabolcs Lengyel, Béla Fülesdi
Dátum:2018
ISSN:0003-2999
Megjegyzések:BACKGROUND: Certain surgical interventions may require a deep neuromuscular block (NMB). Reversal of such a block before tracheal extubation is challenging. Because anticholinesterases are ineffective in deep block, sugammadex 4 mg/kg has been recommended for the reversal of rocuronium- or vecuronium-induced deep NMB. However, this recommendation requires opening 2 vials of 200 mg sugammadex, which results in an increase in drug costs. Therefore, we sought a less expensive solution for the induction and reversal of deep NMB. Although the optimal dose of sugammadex for antagonism of deep block from pipecuronium has not been established, data pertaining to moderate block are available. Accordingly, we hypothesized that sugammadex 2 mg/kg would be a proper dose to reverse deep pipecuronium block, enabling us to avoid cost increases. In the present study, we compared sugammadex 2 mg/kg with the standard dose of 4 mg/kg for reversal of deep block from pipecuronium. METHODS: This single-center, randomized, double-blind, 2 parallel-arms, noninferiority study comprised 50 patients undergoing general anesthesia with propofol, sevoflurane, fentanyl, and pipecuronium. Neuromuscular monitoring was performed with acceleromyography (TOF-Watch SX). Noninferiority margin was specified beforehand as an increase in reversal time of no >10% (corresponding to 1 minute for the primary outcome). When the block spontaneously recovered to posttetanic count 1, the patients randomly received sugammadex 2 or 4 mg/kg, and the time from the injection to the train-offour (TOF) ratio of 1.0 was measured. Primary outcome was the time to achieve the normalized TOF ratio of 0.9 in a particular patient. Residual or recurrent postoperative NMB was additional end point. RESULTS: Each patient recovered to the normalized TOF ratio of 0.9. In the 2 mg/kg group, reversal time was 1.73 ? 1.03 minutes (95% confidence interval [CI], 1.33?2.13; n = 25), and in the 4 mg/kg group, reversal time was 1.42 ? 0.63 minutes (mean ? standard deviation) (95% CI, 1.17?1.67; n = 25). The mean difference in reversal times between the 2 groups was 0.31 minutes (95% CI, ?0.18 to 0.8), and the upper limit of CI was below the noninferiority margin of 1 minute. Postoperative block did not occur. CONCLUSIONS: The effect of sugammadex 2 mg/kg was noninferior to that of 4 mg/kg in reversing posttetanic count-1 degree pipecuronium block. Sugammadex reversal of deep pipecuronium block appears to be effective. (Anesth Analg 2018;127:1344?50)
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Anesthesia And Analgesia. - 127 : 6 (2018), p. 1344-1350. -
További szerzők:Asztalos László (1985-) (aneszteziológus) Szabó-Maák Zoltán (1984-) (aneszteziológus, intenzív terápiás szakorvos) Nemes Réka (1985-) (aneszteziológus, intenzív terápiás szakorvos) Pongrácz Adrienn (1971-) (aneszteziológus, intenzív terápiás szakorvos) Lengyel Szabolcs (1971-) (biológus) Fülesdi Béla (1961-) (aneszteziológus)
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10.

001-es BibID:BIBFORM060544
Első szerző:Tassonyi Edömér (aneszteziológus)
Cím:Reversal of Pipecuronium-Induced Moderate Neuromuscular Block with Sugammadex in the Presence of a Sevoflurane Anesthetic / Edömér Tassonyi, Adrienn Pongrácz, Réka Nemes, László Asztalos, Szabolcs Lengyel, Béla Fülesdi
Dátum:2015
ISSN:0003-2999
Megjegyzések:BACKGROUND:Pipecuronium is a steroidal neuromuscular blocking agent. Sugammadex, a relaxant binding ?-cyclodextrin derivative, reverses the effect of rocuronium, vecuronium, and pancuronium. We investigated whether sugammadex reverses moderate pipecuronium-induced neuromuscular blockade (NMB) and the doses required to achieve reversal.METHODS:This single-center, randomized, double-blind, 5-group parallel-arm study comprised 50 patients undergoing general anesthesia with propofol, sevoflurane, fentanyl, and pipecuronium. Neuromuscular monitoring was performed with acceleromyography (TOF-Watch SX) according to international standards. When the NMB recovered spontaneously to train-of-four count 2, patients randomly received 1.0, 2.0, 3.0, or 4.0 mg/kg of sugammadex or placebo. Recovery time from sugammadex injection to normalized train-of-four (TOF) ratio 0.9 was the primary outcome variable. The recovery time from the sugammadex injection to final T1 was the secondary end point. Postoperative neuromuscular functions were also assessed.RESULTS:Each patient who received sugammadex recovered to a normalized TOF ratio of 0.9 within 5.0 minutes (95% lower confidence interval for the lowest dose 70.1%; for all doses 90.8%) and 79% of these patients reached a normalized TOF ratio 0.9 within 2.0 minutes (95% lower confidence interval for the lowest dose 26.7%; for all doses 63.7%). T1 recovered several minutes after the TOF ratio. No residual postoperative NMB was observed.CONCLUSIONS:Sugammadex adequately and rapidly reverses pipecuronium-induced moderate NMB during sevoflurane anesthesia. Once the train-of-four count has spontaneously returned to 2 responses following pipecuronium administration, a dose of 2.0 mg/kg of sugammadex is sufficient to reverse the NMB.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Anesthesia And Analgesia. - 121 : 2 (2015), p. 373-380. -
További szerzők:Pongrácz Adrienn (1971-) (aneszteziológus, intenzív terápiás szakorvos) Nemes Réka (1985-) (aneszteziológus, intenzív terápiás szakorvos) Asztalos László (1985-) (aneszteziológus) Lengyel Szabolcs (1971-) (biológus) Fülesdi Béla (1961-) (aneszteziológus)
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