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1.

001-es BibID:BIBFORM112258
035-os BibID:(WoS)000082379000008 (Scopus)0032828384
Első szerző:Adler, Lenard A.
Cím:Vitamin E Treatment for Tardive Dyskinesia / Adler Lenard A., Rotrosen John, Edson Robert, Lavori Philip, Lohr James, Hitzemann Robert, Raisch Dennis, Caligiuri Michael, Tracy Kathlene, Frecska Ede
Dátum:1999
ISSN:0003-990X
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Archives Of General Psychiatry. - 56 : 9 (1999), p. 836-841. -
További szerzők:Rotrosen, John Edson, Robert Lavori, Philip Lohr, James Hitzemann, Robert Raisch, Dennis Caligiuri, Michael Tracy, Kathlene Frecska Ede (1953-) (pszichiáter)
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DOI
Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM034461
035-os BibID:PMID:9133752 WOS:A1997WU64600009
Első szerző:Edson, Robert
Cím:Interrater reliability issues in multicenter trials, part II : statistical procedures used in Department of Veterans Affairs Cooperative Study #3941 / Edson, R., Lavori, P., Tracy, K., Adler, L. A., Rotrosen, J., Gowda, S., Mukherjee, S., Williams, B., Duncan, E., Vaid, G., Schwartz, M., Hitzemann, R., Frecska, E., Manicone, P., Caroff, S., Campbell, E. C., Havey, J., Casey, D., Hoffman, W., Hansen, T., Brundage, T., Hixs, M., Hanna, M., Lohr, J., Browning, J., Kanof, P., Fain, R., Krystal, J., DSouza, D. C., Damon, D., Marder, S. S., Ames, D., Ross, D., Doorack, J., Hitzemann, R., Haakenson, C., Miller, M.
Dátum:1997
ISSN:0006-3223
Megjegyzések:The primary goal of Veterans Affairs (VA) Cooperative Study (CS) #394 is to determine if vitamin E is a safe and efficacious treatment for tardive dyskinesia (TD). The study uses various instruments to assess subjects for movement disorders (Abnormal Involuntary Movement Scale [AIMS], and Barnes Akathisia Scale [BAS]), psychopathology (Anchored Brief Psychiatric Rating Scale [BPRS]), and level of functioning (Global Assessment of Functioning scale [GAF]). Since the study involves nine sites, each with its own set of raters, it is important to establish and maintain high interrater reliability (IRR) on these instruments throughout the study and to identify raters who differ significantly from the others. To make this determination, personnel at each site assessed subjects from standardized videotapes on the AIMS, BAS, and Anchored BPRS, and rated written vignettes on the GAF. We fit these data to a two-way additive model to identify nonstandardized raters (i.e., those whose average ratings were significantly lower or higher than the others, or those whose scores, after adjusting for subject and rater effects, were highly variable). The proportion of nonstandardized raters ranged from 7 percent (Anchored BPRS) to 33 percent (AIMS). The estimated intraclass correlation coefficients (ICCs) indicated moderate reliability for the AIMS, BAS, and Anchored BPRS (0.73 to 0.75) and excellent agreement for the GAF (0.90). The companion article (Part I: Tracy et al. 1997, page 53 of this issue) describes the procedures used to train the raters for this study.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
külföldön készült közlemény
Megjelenés:Psychopharmacology Bulletin. - 33 : 1 (1997), p. 59-67. -
További szerzők:Lavori, Philip Tracy, Kathlene Adler, Lenard A. Rotrosen, John Gowda, S. Mukherjee, Subhendu Williams, B. Duncan, E. Vaid, G. Schwartz, M. Hitzemann, Robert Frecska Ede (1953-) (pszichiáter) Manicone, P. Caroff, Stanley Campbell, E. C. Havey, J. Casey, D. Hoffman, W. Hansen, T. Brundage, T. Hixs, M. Hanna, M. Lohr, J. Browning, J. Kanof, P. Fain, R. Krystal, J. DSouza, D. C. Damon, D. Marder, S. S. Ames, D. Ross, David Doorack, J. Hitzemann, R. Haakenson, C. Miller, M.
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3.

001-es BibID:BIBFORM034462
035-os BibID:PMID:9050126
Első szerző:Hirschowitz, Jack
Cím:The Dose Reduction in Schizophrenia (DORIS) Study : a final report / J. Hirschowitz, R. Hitzemann, K. Piscani, G. Burr, E. Frecska, D. Culliton, M. Mann, C. Curtis
Dátum:1997
ISSN:0920-9964
Megjegyzések:Twenty-one medication-free chronic schizophrenics were randomly assigned to three treatment groups: 50% blockade of the bromocriptine growth hormone (GH) response, 100% blockade or 10 ng/ml haloperidol. Only seven of the 21 patients showed a significant improvement after 6 weeks in positive psychotic symptoms; six of the seven responders came from the 50 and 100% blockade groups, suggesting greater efficacy at lower doses. Fifty percent blockade was associated with an average daily haloperidol dose of 3.2 mg and plasma haloperidol levels below the limit of detection (< 1 ng/ml). 100% blockade was associated with a daily dose of 6.5 mg and a plasma haloperidol level of 1 ng/ml. Negative symptoms significantly improved in only four of the 21 patients, and three of these patients were from the 100% blockade group. Twenty-nine patients currently receiving 20 mg/day haloperidol were randomly assigned to three treatment groups: placebo, 100% blockade of the GH response and 10 ng/ml. Patients in the placebo group showed significant deterioration along both the positive and negative symptom dimensions. There were no significant symptom differences between the 100% blockade and the 10 ng/ml groups. The patients in the 100% blockade group had on average a daily dose reduction from 20 to 11 mg/day and a 65% reduction in the plasma haloperidol level. There was a 70% difference in the average daily dose for 100% blockade between the two study arms. The higher daily dose in the dose-reduction arm may reflect receptor up-regulation and/or other "tolerance'-like mechanisms associated with chronic neuroleptic administration.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
külföldön készült közlemény
Megjelenés:Schizophrenia Research. - 23 : 1 (1997), p. 31-43. -
További szerzők:Hitzemann, Robert Piscani, Kathy Burr, G. Frecska Ede (1953-) (pszichiáter) Culliton, D Mann, Matthias Curtis, C.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
Szerző által megadott URL
DOI
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4.

001-es BibID:BIBFORM034459
035-os BibID:WOS:A1997WU64600008 PMID:9133751
Első szerző:Tracy, Kathlene
Cím:Interrater reliability issues in multicenter trials, part I : theoretical concepts and operational procedures used in Department of Veterans Affairs Cooperative Study #3941 / Tracy, K., Adler, L. A., Rotrosen, J., Edson, R., Lavori, P., Gowda, S., Mukherjee, S., Williams, B., Duncan, E., Schwartz, M., Hitzemann, R., Frecska, E., Manicone, P., Caroff, S., Campbell, C., Havey, J., Casey, D., Hoffman, W., Hansen, T., Brundage, T., Hixs, M., Hanna, M., Lohr, J., Browning, J., Kanof, P., Fain, R., Krystal, J., DSouza, D. C., Damon, D., Marder, S. S., Ames, D., Ross, D., Doorack, J., Hitzemann, R., Lohr, J., Haakenson, C., Miller, M.
Dátum:1997
ISSN:0006-3223
Megjegyzések:This article describes a standardized method for establishing and maintaining desired levels of interrater reliability (IRR) in multicenter trials. The procedure involves six steps: distribution of procedural guides, distribution of an introduction tape, initial distribution of patient interviews to rate, training at the study kickoff meeting, ongoing IRR monitoring, and group training throughout the study. This method is being used in a national Veterans Affairs Cooperative Study (CS #394), involving nine sites to examine the treatment effects of vitamin E on tardive dyskinesia. The six-step standardized process allowed for early detection of areas of concern in assessment administration. When comparing intraclass correlation coefficients (ICCs) at different points in the initial training, the Barnes Akathisia Scale and Anchored Brief Psychiatric Rating Scale reliability improved from 0.68 to 0.74 and from 0.54 to 0.87, respectively. After analyzing the ratings collected prior to the start of CS #394, data were collected to conduct the first check on Abnormal Involuntary Movement Scale (AIMS) IRR during enrollment; the estimated ICC for the AIMS had decreased from 0.87 to 0.60. Raters were instructed to re-assess the subjects from the first videotape on the AIMS and received additional training. The re-rating indicated very good reliability, 0.84, IRR was measured once for the Global Assessment of Functioning Scale resulting in an ICC of 0.90. The companion article (Part II: Edson et al. 1997, page 59 of this issue) describes the statistical procedures used to measure IRR.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
külföldön készült közlemény
Megjelenés:Psychopharmacology Bulletin. - 33 : 1 (1997), p. 53-57. -
További szerzők:Adler, Lenard A. Rotrosen, John Edson, Robert Lavori, Philip Gowda, S. Mukherjee, Subhendu Williams, B. Duncan, E. Schwartz, M. Hitzemann, Robert Frecska Ede (1953-) (pszichiáter) Manicone, P. Caroff, Stanley Campbell, Cabrina Havey, J. Casey, D. Hoffman, W. Hansen, T. Brundage, T. Hixs, M. Hanna, M. Lohr, J. Browning, J. Kanof, P. Fain, R. Krystal, J. DSouza, D. C. Damon, D. Marder, S. S. Ames, D. Ross, David Doorack, J. Hitzemann, R. Lohr, James Haakenson, C. Miller, M.
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5.

001-es BibID:BIBFORM055340
Első szerző:Volkow, Nora D.
Cím:Regional brain metabolic response to lorazepam in alcoholics during early and late alcohol detoxification / Nora D. Volkow, Gene-Jack Wang, John E. Overall, Robert Hitzemann, Joanna S. Fowler, Naomi Pappas, Ede Frecska, Kathleen Piscani
Dátum:1997
ISSN:0145-6008
Megjegyzések:Changes in GABA function have been postulated to be involved in alcohol tolerance, withdrawal and addiction. In this study we measured regional brain metabolic responses to lorazepam, to indirectly assess GABA function (benzodiazepines facilitate GABAergic neurotransmission), in alcoholics during early and late withdrawal. Brain metabolism was measured using PET and 2-deoxy-2[18F]fluoro-D-glucose after placebo (baseline) and after lorazepam (30 micrograms/kg intravenously) in 10 alcoholics and 16 controls. In the alcoholics evaluations were performed 2 to 3 weeks after detoxification and were repeated 6 to 8 weeks later. Controls were also evaluated twice at a 6 to 8 weeks interval. While during the initial evaluation metabolism was significantly lower for most brain regions in the alcoholics than in controls in the repeated evaluation the only significant differences were in cingulate and orbitofrontal cortex. Lorazepam-induced decrements in metabolism did not change with protracted alcohol withdrawal and the magnitude of these changes were similar in controls and alcoholics except for a trend towards a blunted response to lorazepam in orbitofrontal cortex in alcoholics during the second evaluation. Abnormalities in orbitofrontal cortex and cingulate gyrus in alcoholics are unlikely to be due to withdrawal since they persist 8 to 11 weeks after detoxification. The fact that there was only a trend of significance for an abnormal response to lorazepam in orbitofrontal cortex indicates that mechanisms other than GABA are involved in the brain metabolic abnormalities observed in alcoholic subjects.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
PET
FDG
orbitofrontal cortex
addiction
GABA
Megjelenés:Alcoholism-Clinical and Experimental Research. - 21 : 7 (1997), p. 1278-1284. -
További szerzők:Wang, Gene-Jack Overall, John E. Hitzemann, Robert Fowler, Joanna S. Pappas, Naomi Frecska Ede (1953-) (pszichiáter) Piscani, Kathy
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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