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001-es BibID:	BIBFORM112568
Első szerző:	Frecska Ede (pszichiáter)
Cím:	Selective Attention and Intention in Schizophrenia / Ede Frecska, Kathy Piscani, Carole Symer, Lawrence Greenberg
Dátum:	1994
ISSN:	0893-133X
Tárgyszavak:	Orvostudományok Klinikai orvostudományok konferenciacikk folyóiratcikk
Megjelenés:	Neuropsychopharmacology. - 11 : 4 (1994), p. 268. -
További szerzők:	Piscani, Kathy Symer, Carole Greenberg, Lawrence
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM034448
035-os BibID:	PMID:15081628
Első szerző:	Frecska Ede (pszichiáter)
Cím:	Perceptional and executive deficits of chronic schizophrenic patients in attentional and intentional tasks / Ede Frecska, Carole Symer, Keith White, Kathy Piscani, Zsuzsanna Kulcsar
Dátum:	2004
ISSN:	0165-1781
Megjegyzések:	The present study investigated whether schizophrenic patients could develop appropriate visual orientation and motor set under precuing conditions which contrasted attentional (input selective) and intentional (output selective) information. The aim was to evaluate perceptual performance in processing visuospatial information, and executive performance in response preparation. Stimuli and/or elicited responses were controlled for selective hemispheric engagement. Age, sex and handedness matched groups of 33 chronic schizophrenic patients and 33 normal subjects were tested on choice reaction time (RT) tasks in which warning signals were manipulated regarding either where a target stimulus would occur (selective attention) or which hand to use for responding (response preparation). All subjects benefited from precued information regarding subsequent responses. However, schizophrenic patients were not able to use intentional cues as effectively as control subjects did. Interhemispheric asymmetry of spatial attention was found in patients with schizophrenia, with slowing of responses to uncued targets presented in the right visual field. There was also a decreased advantage of within-hemisphere stimulus-response conditions in the schizophrenic group. Our results support the notion that a dysfunction involving parietal and premotor areas has potential importance in the schizophrenic illness. We replicated findings which indicate that deficits of information processing in schizophrenia may affect left hemispheric mechanisms to a larger extent. The results also point toward a possible abnormal connectivity between frontal and parietal circuits in schizophrenia.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban külföldön készült közlemény
Megjelenés:	Psychiatry Research. - 126 : 1 (2004), p. 63-75. -
További szerzők:	Symer, Carole White, Keith D. Piscani, Kathy Kulcsár Zsuzsanna
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM034462
035-os BibID:	PMID:9050126
Első szerző:	Hirschowitz, Jack
Cím:	The Dose Reduction in Schizophrenia (DORIS) Study : a final report / J. Hirschowitz, R. Hitzemann, K. Piscani, G. Burr, E. Frecska, D. Culliton, M. Mann, C. Curtis
Dátum:	1997
ISSN:	0920-9964
Megjegyzések:	Twenty-one medication-free chronic schizophrenics were randomly assigned to three treatment groups: 50% blockade of the bromocriptine growth hormone (GH) response, 100% blockade or 10 ng/ml haloperidol. Only seven of the 21 patients showed a significant improvement after 6 weeks in positive psychotic symptoms; six of the seven responders came from the 50 and 100% blockade groups, suggesting greater efficacy at lower doses. Fifty percent blockade was associated with an average daily haloperidol dose of 3.2 mg and plasma haloperidol levels below the limit of detection (< 1 ng/ml). 100% blockade was associated with a daily dose of 6.5 mg and a plasma haloperidol level of 1 ng/ml. Negative symptoms significantly improved in only four of the 21 patients, and three of these patients were from the 100% blockade group. Twenty-nine patients currently receiving 20 mg/day haloperidol were randomly assigned to three treatment groups: placebo, 100% blockade of the GH response and 10 ng/ml. Patients in the placebo group showed significant deterioration along both the positive and negative symptom dimensions. There were no significant symptom differences between the 100% blockade and the 10 ng/ml groups. The patients in the 100% blockade group had on average a daily dose reduction from 20 to 11 mg/day and a 65% reduction in the plasma haloperidol level. There was a 70% difference in the average daily dose for 100% blockade between the two study arms. The higher daily dose in the dose-reduction arm may reflect receptor up-regulation and/or other "tolerance'-like mechanisms associated with chronic neuroleptic administration.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk külföldön készült közlemény
Megjelenés:	Schizophrenia Research. - 23 : 1 (1997), p. 31-43. -
További szerzők:	Hitzemann, Robert Piscani, Kathy Burr, G. Frecska Ede (1953-) (pszichiáter) Culliton, D Mann, Matthias Curtis, C.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat Szerző által megadott URL DOI
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001-es BibID:	BIBFORM055340
Első szerző:	Volkow, Nora D.
Cím:	Regional brain metabolic response to lorazepam in alcoholics during early and late alcohol detoxification / Nora D. Volkow, Gene-Jack Wang, John E. Overall, Robert Hitzemann, Joanna S. Fowler, Naomi Pappas, Ede Frecska, Kathleen Piscani
Dátum:	1997
ISSN:	0145-6008
Megjegyzések:	Changes in GABA function have been postulated to be involved in alcohol tolerance, withdrawal and addiction. In this study we measured regional brain metabolic responses to lorazepam, to indirectly assess GABA function (benzodiazepines facilitate GABAergic neurotransmission), in alcoholics during early and late withdrawal. Brain metabolism was measured using PET and 2-deoxy-2[18F]fluoro-D-glucose after placebo (baseline) and after lorazepam (30 micrograms/kg intravenously) in 10 alcoholics and 16 controls. In the alcoholics evaluations were performed 2 to 3 weeks after detoxification and were repeated 6 to 8 weeks later. Controls were also evaluated twice at a 6 to 8 weeks interval. While during the initial evaluation metabolism was significantly lower for most brain regions in the alcoholics than in controls in the repeated evaluation the only significant differences were in cingulate and orbitofrontal cortex. Lorazepam-induced decrements in metabolism did not change with protracted alcohol withdrawal and the magnitude of these changes were similar in controls and alcoholics except for a trend towards a blunted response to lorazepam in orbitofrontal cortex in alcoholics during the second evaluation. Abnormalities in orbitofrontal cortex and cingulate gyrus in alcoholics are unlikely to be due to withdrawal since they persist 8 to 11 weeks after detoxification. The fact that there was only a trend of significance for an abnormal response to lorazepam in orbitofrontal cortex indicates that mechanisms other than GABA are involved in the brain metabolic abnormalities observed in alcoholic subjects.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban PET FDG orbitofrontal cortex addiction GABA
Megjelenés:	Alcoholism-Clinical and Experimental Research. - 21 : 7 (1997), p. 1278-1284. -
További szerzők:	Wang, Gene-Jack Overall, John E. Hitzemann, Robert Fowler, Joanna S. Pappas, Naomi Frecska Ede (1953-) (pszichiáter) Piscani, Kathy
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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