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001-es BibID:	BIBFORM112641
035-os BibID:	(Scopus)85162257307
Első szerző:	Frecska Ede (pszichiáter)
Cím:	Beyond Mind - Body Dualism : pluralistic Concepts of the Soul in Mongolian Shamanistic Traditions / Ede Frecska, Ágnes Birtalan, Michael Winkelman
Dátum:	2023
ISSN:	1355-8250
Tárgyszavak:	Bölcsészettudományok Néprajz és kulturális antropológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal Of Consciousness Studies. - 30 : 5-6 (2023), p. 177-190. -
További szerzők:	Birtalan Ágnes Winkelman, Michael J.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM067785
035-os BibID:	(scopus)84966269383 (wos)000371109600001
Első szerző:	Frecska Ede (pszichiáter)
Cím:	The therapeutic potentials of ayahuasca : possible effects against various diseases of civilization / Frecska, E., Bokor, P., Winkelman, M.
Dátum:	2016
Megjegyzések:	Ayahuasca is an Amazonian psychoactive brew of two main components. Its active agents are ?-carboline and tryptamine derivatives. As a sacrament, ayahuasca is still a central element of many healing ceremonies in the Amazon Basin and its ritual consumption has become common among the mestizo populations of South America. Ayahuasca use amongst the indigenous people of the Amazon is a form of traditional medicine and cultural psychiatry. During the last two decades, the substance has become increasingly known among both scientists and laymen, and currently its use is spreading all over in the Western world. In the present paper we describe the chief characteristics of ayahuasca, discuss important questions raised about its use, and provide an overview of the scientific research supporting its potential therapeutic benefits. A growing number of studies indicate that the psychotherapeutic potential of ayahuasca is based mostly on the strong serotonergic effects, whereas the sigma-1 receptor agonist effect of its active ingredient dimethyltryptamine raises the possibility that the ethnomedical observations on the diversity of treated conditions can be scientifically verified. Moreover, in the right therapeutic or ritual setting with proper preparation and mindset of the user, followed by subsequent integration of the experience, ayahuasca has proven effective in the treatment of substance dependence. This article has two important take-home messages: 1) the therapeutic effects of ayahuasca are best understood from a bio-psycho-socio-spiritual model, and 2) on the biological level ayahuasca may act against chronic low grade inflammation and oxidative stress via the sigma-1 receptor which can explain its widespread therapeutic indications.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk addiktológia ayahuasca civilizációs betegségek dimetiltriptamine oxidatív stressz
Megjelenés:	Frontiers in Pharmacology. - 7 : 35 (2016), p. 1-17. -
További szerzők:	Bokor Petra Winkelman, Michael J.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM047792
035-os BibID:	PMID:23619992
Első szerző:	Frecska Ede (pszichiáter)
Cím:	A possibly sigma-1 receptor mediated role of dimethyltryptamine in tissue protection, regeneration, and immunity / Ede Frecska, Attila Szabo, Michael J. Winkelman, Luis E. Luna, Dennis J. McKenna
Dátum:	2013
ISSN:	0300-9564
Megjegyzések:	N,N-dimethyltryptamine (DMT) is classified as a naturally occurring serotonergic hallucinogen of plant origin. It has also been found in animal tissues and regarded as an endogenous trace amine transmitter. The vast majority of research on DMT has targeted its psychotropic/psychedelic properties with less focus on its effects beyond the nervous system. The recent discovery that DMT is an endogenous ligand of the sigma-1 receptor may shed light on yet undiscovered physiological mechanisms of DMT activity and reveal some of its putative biological functions. A three-step active uptake process of DMT from peripheral sources to neurons underscores a presumed physiological significance of this endogenous hallucinogen. In this paper, we overview the literature on the effects of sigma-1 receptor ligands on cellular bioenergetics, the role of serotonin, and serotoninergic analogues in immunoregulation and the data regarding gene expression of the DMT synthesizing enzyme indolethylamine-N-methyltransferase in carcinogenesis. We conclude that the function of DMT may extend central nervous activity and involve a more universal role in cellular protective mechanisms. Suggestions are offered for future directions of indole alkaloid research in the general medical field. We provide converging evidence that while DMT is a substance which produces powerful psychedelic experiences, it is better understood not as a hallucinogenic drug of abuse, but rather an agent of significant adaptive mechanisms that can also serve as a promising tool in the development of future medical therapies.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Neural Transmission. - 120 : 9 (2013), p. 1295-1303. -
További szerzők:	Szabó Attila (1981-) (molekuláris biológus, immunológus, filozófus) Winkelman, Michael J. Luna, Luis Eduardo McKenna, Dennis J.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM113462
035-os BibID:	(WoS)001046171000001 (Scopus)85164379084
Első szerző:	Winkelman, Michael J.
Cím:	The potential of psychedelics for the treatment of Alzheimer's disease and related dementias / Winkelman Michael James, Szabo Attila, Frecska Ede
Dátum:	2023
ISSN:	0924-977X
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	European Neuropsychopharmacology. - 76 (2023), p. 3-16. -
További szerzők:	Szabó Attila Frecska Ede (1953-) (pszichiáter)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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