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1.

001-es BibID:BIBFORM091543
Első szerző:Csikós Anett (biomérnök, biológia-földrajz tanár)
Cím:Evaluation of zinc and copper levels in vaginal tissues and whole blood : correlation with age / Csikós Anett, Kozma Bence, Baranyai Edina, Miklós Ida, Larson Kindra, Póka Róbert, Takacs Peter
Dátum:2021
ISSN:1472-6874
Megjegyzések:Background: Zinc and copper are essential trace elements and play a crucial role in the homeostasis of connective tissues. In this study, we aimed to define zinc and copper levels in the vaginal tissue and establish whether a correlation exists between the zinc and copper levels either or both in whole blood or vaginal tissue samples and whether the finding correlates with the age of the patient or at least with her menopausal status. Methods: We collected whole blood and vaginal tissue samples from 32 women and measured their zinc and copper levels by inductively coupled plasma optical emission spectrometry. We have performed Student's t test to evaluate the differences in the mean levels of trace elements and multiple regression to evaluate the association between vaginal tissue zinc/copper levels and age, menopausal status, number of vaginal deliveries, and zinc/copper blood levels. Results: Zinc levels were significantly higher in both the vaginal tissues and whole blood samples than copper levels (p?<?0.01). In the vaginal tissue samples, a strong positive correlation could be detected between zinc and copper levels (r?=?0.82, p?<?0.01). In the vaginal tissue, a negative correlation was found for zinc and copper levels with the age of women (r?=???0.27, p?=?0.04 and r?=???0.56, p?<?0.01). Multiple linear regression model (age, menopausal status, vaginal delivery and copper/zinc blood levels) showed that only age remained a significant predictor for zinc and copper vaginal tissues levels (p?=?0.03, 95% CI ??2.28 to ??0.06; p?=?0.004, 95% CI ??1.76 to ??0.34). Conclusions: Zinc and copper levels in the vaginal tissue decline with age. Out of the examined variables (age, menopausal status, vaginal delivery, and copper/zinc levels), only age is a significant predictor of vaginal zinc/copper levels.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Ageing
Cooper
ICP-OES
Vagina
Whole blood
Zinc
Megjelenés:BMC Women's Health. - 21 : 1 (2021), p. 1-7. -
További szerzők:Kozma Bence (1982-) (szülész-nőgyógyász) Baranyai Edina (1987-) (környezetkutató) Miklós Ida (1962-) (biológus) Larson, Kindra Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus) Takács Péter (1968-) (szülész-nőgyógyász)
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Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM084868
Első szerző:Damjanovich Péter Gábor (szülész-nőgyógyász)
Cím:Cervicovaginal lavage fluid zinc level as a marker of vaginal atrophy / Damjanovich Peter, Sipos Attila Gergely, Larson Kindra, Cunningham Tina D., Takacs Peter, Kozma Bence
Dátum:2020
ISSN:1530-0374
Megjegyzések:Objectives: This study aimed to investigate the correlation between cervicovaginal fluid zinc levels and participants' menopausal status and the presence of vulvovaginal symptoms of genitourinary syndrome of menopause. Methods: Women included in the study underwent a pelvic examination, collection of vaginal cytology, and cervicovaginal lavage was performed in a standardized fashion. The cervicovaginal lavage zinc content was determined. The vaginal health index was calculated, and the visual analog scale was obtained based on the participant's burning, itching, vaginal pain, dyspareunia, dryness, and dysuria. Results: One hundred twenty women participated in the study. Eighty-two participants were menopausal. The mean vaginal health index was 15 ? 6, while the total visual analog scale score was 14 ? 14. We found significant differences between cervicovaginal lavage zinc level and age group, menopausal status, presence of vaginal dryness, and vaginal atrophy. We also found a moderate positive correlation between Vaginal Maturation Value and cervicovaginal lavage zinc levels (r = 0.495, P value < 0.01) in the correlation analysis. However, in the multivariate regression model, including all significant factors, only vaginal atrophy remained significant. Conclusions: We found a significant association between vaginal atrophy (vaginal maturation value < 50) and cervicovaginal lavage zinc levels. Zinc levels of cervicovaginal lavage could be used as a new marker of vaginal atrophy.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Menopause. - 27 : 7 (2020), p. 776-779. -
További szerzők:Sipos Attila Gergely (1990-) (szülész-nőgyógyász) Larson, Kindra Cunningham, Tina D. Takács Péter (1968-) (szülész-nőgyógyász) Kozma Bence (1982-) (szülész-nőgyógyász)
Pályázati támogatás:GINOP-2.1.1-15-2016-00783
GINOP
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Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM084850
Első szerző:Kozma Bence (szülész-nőgyógyász)
Cím:Association between pelvic organ prolapse types and levator-urethra gap as measured by 3D transperineal ultrasound / Kozma Bence, Larson Kindra, Scott Lauren, Cunningham Tina, Abuhamad Alfred, Póka Róbert, Takacs Péter
Dátum:2018
ISSN:0937-3462
Megjegyzések:Introduction: Pelvic organ prolapse (POP) is a common condition affecting many women. During delivery, the components of the levator ani muscle undergo significant distention and stretching leading to muscle damage 10-25% of the time. Injury to the pelvic floor muscles can result in floor dysfunction like POP or stress urinary incontinence. Levator ani defects can be diagnosed clinically by vaginal palpation or using transperineal ultrasound. Previously the standard sonographic diagnosis of levator avulsion required observation of an abnormal insertion of the muscle on tomographic ultrasound imaging (TUI). But most recently the measurement of the levator?urethra gap (LUG) has been described as a quantitative tool in this regard. LUG is the distance between the center of the urethral lumen and insertion of the levator on the inferior pubic ramus, determined bilaterally, in axial slices on transperineal 3D ultrasound. The measurement of LUG is reproducible and an abnormal LUG (?25mm) has been strongly associated with avulsion diagnosed by vaginal palpation. Objectives: To evaluate the association between POP types and LUG as measured by 3D transperineal tomographic ultrasound (TPUS). Methods: A retrospective study was carried out on ninety-eight women with symptomatic POP. 3D TPUS images and Pelvic Organ Prolapse Quantification coordinates were reviewed. Each vaginal compartment was staged for the degree of prolapse, and total number of involved compartments identified. LUG was measured on 3D tomographic ultrasound images as the distance between the center of the urethra and the levator insertion bilaterally. Based upon prior studies, an abnormal LUG?25mm indicated levator avulsion. LUG and presence or absence of unilateral/bilateral avulsions was analyzed with reference to the clinical diagnosis of prolapse [single vs. multi compartment, and mild (stage II) vs. severe (stage III-IV)]. Generalized logit models were used to evaluate the association between avulsion and prolapse type and stage. Results: The LUG was significantly larger in women with multi compartment compared to single compartment POP (28.9?4.1mm vs. 22.7 ?4.1mm, P<0.01). Similarly, LUG was significantly larger in women with severe (stage III-IV) compared to mild POP (stage II) (28.8 ?4.7mm vs. 23.3?4.5mm, P<0.01). Women with severe prolapse were 32 times more likely than women with mild prolapse to have bilateral levator avulsion. Those with POP involving all three vaginal compartments were 76 times more likely than single compartment POP to have bilateral levator avulsions. Conclusions: Bilateral levator ani avulsion as diagnosed by LUG measurements of ?25mm at rest is associated with multi compartment, sever prolapse.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:International Urogynecology Journal. - 29 : S1 (2018), p. 174. -
További szerzők:Larson, Kindra Scott, Lauren Cunningham, Tina D. Abuhamad, Alfred Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus) Takács Péter (1968-) (szülész-nőgyógyász)
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM075686
Első szerző:Kozma Bence (szülész-nőgyógyász)
Cím:Association between pelvic organ prolapse types and levator-urethra gap as measured by 3D transperineal ultrasound / Bence Kozma, Kindra Larson, Lauren Scott, Tina D. Cunningham, Alfred Abuhamad, Robert Poka, Peter Takacs
Dátum:2018
ISSN:0278-4297
Megjegyzések:Objectives : To evaluate the association between pelvic organ prolapse (POP)types and levator-urethra gap (LUG) as measured by 3-dimensional transperineal tomographic ultrasound. Methods : A retrospective study was carried out on 98 women with symptomatic POP. Three-dimensional transperineal tomographic ultrasound images and POP quantification coordinates were reviewed. Each vaginal compartment was staged for the degree of prolapse, and total number of involved compartments identified. LUG was measured on 3-dimensional tomographic sonograms as the distance between the center of the urethra and the levator insertion bilaterally. Based on prior studies, an abnormal LUG of 25mm or greater indicated levator avulsion. The LUG and the presence or absence of unilateral/bilateral avulsions was analyzed with reference to the clinical diagnosis of prolapse (single versus multicompartment, and mild [stage II] versus severe [stage III?IV]). Generalized logit models were used to evaluate the association between avulsion and prolapse type and stage. Results ? The LUG was substantially larger in women with multicompartment compared to single-compartment POP (28.964.1mm versus 22.764.1mm, P<.01). Similarly, LUG was substantially larger in women with severe (stage III?IV) compared to mild (stage II) POP (28.864.7mm versus 23.364.5 mm, P<.01). Women with severe prolapse were 32 times more likely than women with mild prolapse to have bilateral levator avulsion. Those with POP involving all 3 vaginal compartments were 76 times more likely than single-compartment POP to have bilateral levator avulsions. Conclusions : Bilateral levator ani avulsion as diagnosed by LUG measurements of 25mm or greater at rest is associated with multicompartment, severe prolapse.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
levator ani avulsion
levator-urethra gap
pelvic organ prolapse
transperineal ultrasound
Megjelenés:Journal Of Ultrasound In Medicine. - 37 : 12 (2018), p. 2849-2854. -
További szerzők:Larson, Kindra Scott, Lauren Cunningham, Tina D. Abuhamad, Alfred Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus) Takács Péter (1968-) (szülész-nőgyógyász)
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Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM094864
Első szerző:Sipos Attila Gergely (szülész-nőgyógyász)
Cím:Fractional CO2 laser treatment effect on cervicovaginal lavage zinc and copper levels : a prospective cohort study / Attila G. Sipos, Krisztina Pákozdy, Szilvia Jäger, Kindra Larson, Peter Takacs, Bence Kozma
Dátum:2021
ISSN:1472-6874
Megjegyzések:Background: The basic principle of vaginal laser therapy is the rejuvenation of the affected tissue. Zinc and copper are essential nutritional trace elements and have a key role in connective tissue homeostasis. We aimed to investigate the effect of vaginal, fractional CO2 laser treatment on cervicovaginal lavage (CVL) zinc and copper levels. Methods: Twenty-nine postmenopausal women with symptoms of vaginal dryness were enrolled in our prospec-tive cohort study. Three treatments with MonaLisa Touch CO2 laser system were performed four weeks apart. At each treatment CVL was collected, Vaginal Health Index (VHI) was obtained, and Visual Analog Scale (VAS) for vaginal dry-ness was assigned by patients. Zinc and copper concentrations were measured with optical emission spectrometry before each treatment and six weeks after the 3rd treatment. Results: The VHI scores significantly improved after each laser treatment (mean ?SD VHI score, 13.03 ? 4.49 before vs. 15.55 ?4.35 after the 1st, 17.79 ?4.57 after the 2nd and 19.38 ?4.39 after the 3rd treatment, P < 0.01). Similarly, VAS scores reflected improvement (mean ?SD VAS score 6.59 ?2.86 before vs. 4.17 ?2.86 after the 1st, 2.45 ? 2.43 after the 2nd and 1.41 ?1.94 after the 3rd treatment, P < 0.01). CVL zinc levels were significantly higher compared to copper levels (0.06 ?0.04 vs. 0.006 ?0.006 mg/L, P < 0.01) at baseline. While copper levels remained the same through treatments, the CVL zinc level was significantly higher after the second laser treatment compared to the baseline. Conclusions: Fractional CO2 laser treatment of the vagina impacts CVL zinc and copper levels differently. While CVL copper levels were not different after each laser treatment, zinc levels were significantly higher after the second treat-ment before returning to baseline values.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
CO2 laser
Fractional laser
Vagina
Zinc
Copper
Cervicovaginal fluid
Megjelenés:BMC Womens Health. - 21 : 1 (2021), p. 235. -
További szerzők:Pákozdy Krisztina (1991-) (szülész-nőgyógyász) Jäger Szilvia (1974-) (biokémikus) Larson, Kindra Takács Péter (1968-) (szülész-nőgyógyász) Kozma Bence (1982-) (szülész-nőgyógyász)
Pályázati támogatás:GINOP-2.1.1-15-2016-00783
GINOP
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Intézményi repozitóriumban (DEA) tárolt változat
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6.

001-es BibID:BIBFORM081242
Első szerző:Sipos Attila Gergely (szülész-nőgyógyász)
Cím:The Effect of Fractional CO2 Laser Treatment on the Symptoms of Pelvic Floor Dysfunctions : pelvic Floor Distress Inventory-20 Questionnaire / Attila Gergely Sipos, Bence Kozma, Robert Poka, Kindra Larson, Peter Takacs
Dátum:2019
ISSN:0196-8092
Megjegyzések:Background and Objectives: To assess the improve- ment on pelvic floor distress (PFD)?related urogenital symptoms using validated questionnaires after intrava- ginal CO 2 laser treatment. Study Design/Materials and Methods: Forty postme- nopausal women with genitourinary symptoms of menopause (GSM) were enrolled into this prospective cohort study and underwent vaginal laser treatment using MonaLisa Touch ? fractional CO 2 laser system. Patients received three vaginal laser treatments with 360? probe 4 weeks apart. A three?component Pelvic Floor Distress Inventory (PFDI?20) validated question- naire was filled out by each patient before each session and 4 weeks after the final treatment. Wilcoxon rank sum test was used to compare the before and after treatment scores. Results: Pelvic Organ Prolapse Distress Inventory (POPDI?6) scores were not significantly different after the first treatment compared with baseline (mean ? standard deviation [SD], 21 ? 18 vs. 17 ? 15, P = 0.44). However, each subsequent treatment resulted in further, statistically significant improvement in symp- tom scores (14 ? 15, P = 0.03 and 13 ? 13, P = 0.01, after the second and third treatments, respectively). Simi- larly, Urinary Distress Inventory (UDI?6) scores were not significantly different after the first laser treat- ment (mean ? SD, 36 ? 25 vs. 29 ? 23, P = 0.36). After the second and third treatments there were significant improvement in the standardized scores (24 ? 20, P = 0.03 and 22 ? 21, P = 0.01). Colorectal?Anal Dis- tress Inventory (CRADI?8) scores did not change significantly after three laser treatments. Conclusions: Three sessions of microablative fractional CO 2 vaginal laser treatment significantly improves patient reported urinary and pelvic organ prolapse symptoms.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Lasers In Surgery And Medicine. - 51 : 10 (2019), p. 882-886. -
További szerzők:Kozma Bence (1982-) (szülész-nőgyógyász) Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus) Larson, Kindra Takács Péter (1968-) (szülész-nőgyógyász)
Pályázati támogatás:GINOP-2.1.1-15-2016-00783
GINOP
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Intézményi repozitóriumban (DEA) tárolt változat
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7.

001-es BibID:BIBFORM082801
Első szerző:Takács Péter (szülész-nőgyógyász)
Cím:The Effect of Vaginal Microablative Fractional CO2 Laser Treatment on Vaginal Cytology / Takacs Peter, Sipos Attila Gergely, Kozma Bence, Cunningham Tina D., Larson Kindra, Lampé Rudolf, Poka Robert
Dátum:2020
ISSN:0196-8092
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Lasers In Surgery And Medicine. - 52 : 8 (2020), p. 708-712. -
További szerzők:Sipos Attila Gergely (1990-) (szülész-nőgyógyász) Kozma Bence (1982-) (szülész-nőgyógyász) Cunningham, Tina D. Larson, Kindra Lampé Rudolf (1983-) (szülész-nőgyógyász) Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus)
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Intézményi repozitóriumban (DEA) tárolt változat
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8.

001-es BibID:BIBFORM075753
Első szerző:Takács Péter (szülész-nőgyógyász)
Cím:Pelvic organ prolapse : from estrogen to pessary / Peter Takacs, Bence Kozma, Kindra Larson
Dátum:2019
ISSN:1072-3714
Tárgyszavak:Orvostudományok Klinikai orvostudományok szerkesztői levél
Megjelenés:Menopause. - 26 : 2 (2019), p. 121-122. -
További szerzők:Kozma Bence (1982-) (szülész-nőgyógyász) Larson, Kindra
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Intézményi repozitóriumban (DEA) tárolt változat
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9.

001-es BibID:BIBFORM078517
Első szerző:Takács Péter
Cím:Zinc-containing Vaginal Moisturizer Gel Improves Postmenopausal Vulvovaginal Symptoms : a Pilot Study / Peter Takacs, Bence Kozma, Balazs Erdodi, Attila Jakab, Kindra Larson, Robert Poka
Dátum:2019
ISSN:2288-6478 2288-6761
Megjegyzések:Objectives: Although vaginal estrogen is highly effective in alleviating genitourinary symptoms of menopause (GSM), some women are reluctant to use hormonal treatment. Our aim was to evaluate the effect of a zinc-containing vaginal moisturizer gel on GSM. Methods: Women with GSM were enrolled. Patients were asked to use the vaginal gel daily for 2 weeks. Vaginal Health Index (VHI) was calculated. Visual analogue scale (VAS) was obtained on vaginal pain, dryness, burning, itching, dyspareunia and dysuria before and 2 weeks after the completion of treatment. Vaginal cytology was obtained. Vulvovaginal symptom questionnaire (VSQ-21) was used to assess subjective symptoms. Results: Thirty-seven women with GSM participated in the study. The VHI improved significantly (mean ? standard deviation, 13 ? 4 before vs. 17 ? 4 after treatment, P < 0.01). The patient reported VAS combined score was significantly lower after the treatment (18 ? 14 before vs. 7 ? 12 after treatment, P < 0.01). The largest improvement occurred in vaginal dryness. The maturation value did not change significantly. There were no signs of inflammation on vaginal cytology. VSQ-21 combined scores also improved significantly (7.9 ? 5.5 before vs. 2.7 ? 3.6 after the intervention, P < 0.01). Side effects were rare and minor. Conclusions: Novel zinc-containing vaginal moisturizer gel significantly improves postmenopausal vulvovaginal symptoms without serious side effects.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Zinc
Vagina
Menopause
Megjelenés:Journal of Menopausal Medicine. - 25 : 1 (2019), p. 63-68. -
További szerzők:Kozma Bence (1982-) (szülész-nőgyógyász) Erdődi Balázs (1984-) (szülész-nőgyógyász szakorvosjelölt) Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus) Larson, Kindra Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus)
Pályázati támogatás:GINOP-2.1.1-15-2016-00783
GINOP
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Intézményi repozitóriumban (DEA) tárolt változat
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