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001-es BibID:	BIBFORM110793
035-os BibID:	(WoS)000963794300001 (Scopus)85166473548
Első szerző:	Palatka Réka (orvos)
Cím:	Chronic inflammatory intestinal disorders in hidradenitis suppurativa / Palatka Réka, Janka Eszter Anna, Soltész Lilla, Szabó Imre Lőrinc, Kapitány Anikó, Dajnoki Zsolt, Emri Gabriella, Nagy Gábor, Palatka Károly, Zouboulis Christos C., Szegedi Andrea, Gáspár Krisztián
Dátum:	2023
ISSN:	1018-8665
Megjegyzések:	Background: Intestinal symptoms are common in patients with hidradenitis suppurativa (HS). HS patients may experience a broad spectrum of chronic inflammatory intestinal disorders (CIID), not exclusive to inflammatory bowel diseases, which are diagnosed by colonoscopy and intestinal biopsies. The frequency of CIID in patients with HS has not been investigated.Objective: The objectives of this study were to determine the occurrence of CIID in HS and characterise this clinical population. Furthermore, the feasibility of using fecal calprotectin (FC) test or anti-Saccharomyces cerevisiae antibody (ASCA) levels to assess the colonic inflammation of CIID in HS patients was investigated. Methods: All newly diagnosed and untreated HS patients (n=74) were referred to a gastroenterologist for FC followed by colonoscopy after informed consent. C-reactive protein (CRP), white blood cell count, nucleotide-binding-oligomerisation-domain-containing-protein-2 (NOD2) polymorphism, and ASCA levels were measured. Patients were divided into HS-only and HS with CIID (HS+CIID) groups, based on the absence or presence of CIID. Laboratory and clinical parameters (age, gender, HS onset, clinical stage, family history, body mass index (BMI), smoking) were compared between the groups.Results: Thirteen patients complained gastrointestinal symptoms prior to any examination, including 11 in the HS+CIID group. The CIID frequency in HS was 28.4% (n=21/74), based on colonoscopy and histology. Significantly more patients had severe disease state in the HS+CIID group compared with the HS-only group, and BMI was significantly lower in the HS+CIID group (28.20 +/- 5.58 vs. 32.74 +/- 6.45, p=0.006). FC positivity occurred significantly more in HS+CIID patients compared with HS-only patients (90.48% vs. 3.77%, p<0.001), and ASCA IgG levels were significantly elevated in HS+CIID patients (22.08 +/- 23.07 vs 8.41 +/- 10.94 U/mL, p=0.001). The FC test identified HS+CIID patients with 96.23% specificity and 91.3% sensitivity, while ASCA displayed 77.8% sensitivity and 76.3% specificity. Blood count, CRP and the presence of NOD2 polymorphisms were indifferent between the two groups. Conclusion: A high frequency of CIID was detected in the examined HS population. The non-invasive FC test has high sensitivity and specificity for diagnosing CIID in HS patients. Concomitant CIID and HS may indicate the need for an early-start for biological treatment.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Dermatology. - 239 : 4 (2023), p. 592-600. -
További szerzők:	Janka Eszter Anna (1989-) (bőrgyógyász, népegészségügyi szakember) Soltész Lilla (1994-) (orvos) Szabó Imre Lőrinc (1987-) (általános orvos) Kapitány Anikó (1979-) (molekuláris biológus) Dajnoki Zsolt (1985-) (molekuláris biológus) Emri Gabriella (1972-) (bőrgyógyász, allergológus, onkológus) Nagy Gábor (1974-) (laboratóriumi szakorvos, laboratóriumi hematológus és immunológus) Palatka Károly (1961-) (belgyógyász, gasztroenterológus) Zouboulis, Christos C. (1960-) (bőrgyógyász) Szegedi Andrea (1964-) (bőrgyógyász) Gáspár Krisztián (1974-) (bőrgyógyász)
Pályázati támogatás:	K-128250 OTKA K-142348 OTKA PD-131689 OTKA EFOP-3.6.1-16-2016-00022 EFOP ÚNKP-21-5 Egyéb ÚNKP-22-4 Egyéb ERN Skin - ALLOCATE Skin Group Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM094083
035-os BibID:	(cikkazonosító)600017 (WoS)000652520500001 (Scopus)85106199263
Első szerző:	Töröcsik Dániel (bőrgyógyász)
Cím:	Epidermal Growth Factor Modulates Palmitic Acid-Induced Inflammatory and Lipid Signaling Pathways in SZ95 Sebocytes / Dániel Törőcsik, Fruzsina Fazekas, Szilárd Póliska, Andrea Gregus, Eszter Anna Janka, Katalin Dull, Andrea Szegedi, Christos C. Zouboulis, Dóra Kovács
Dátum:	2021
ISSN:	1664-3224
Megjegyzések:	Epidermal growth factor (EGF) acts as a paracrine and autocrine mediator of cell proliferation and differentiation in various types of epithelial cells, such as sebocytes, which produce the lipid-rich sebum to moisturize the skin. However, sebum lipids via direct contact and by penetrating through the epidermis may have regulatory roles on epidermal and dermal cells as well. As EGF receptor (EGFR) is expressed throughout the proliferating and the lipid-producing layers of sebaceous glands (SGs) in healthy and acne-involved skin, we investigated the effect of EGF on SZ95 sebocytes and how it may alter the changes induced by palmitic acid (PA), a major sebum component with bioactive roles. We found that EGF is not only a potent stimulator of sebocyte proliferation, but also induces the secretion of interleukin (IL)6 and down-regulates the expression of genes involved in steroid and retinoid metabolism. Importantly, when applied in combination with PA, the PA-induced lipid accumulation was decreased and the cells secreted increased IL6 levels. Functional clustering of the differentially regulated genes in SZ95 sebocytes treated with EGF, PA or co-treated with EGF+PA further confirmed that EGF may be a potent inducer of hyperproliferative/inflammatory pathways (IL1 signaling), an effect being more pronounced in the presence of PA. However, while a group of inflammatory genes was up-regulated significantly in EGF+PA co-treated sebocytes, PA treatment in the absence of EGF, regulated genes only related to cell homeostasis. Meta-analysis of the gene expression profiles of whole acne tissue samples and EGF- and EGF+PA ?treated SZ95 sebocytes showed that the EGF+PA co-activation of sebocytes may also have implications in disease. Altogether, our results reveal that PA-induced lipid accumulation and inflammation can be modulated by EGF in sebocytes, which also highlights the need for system biological approaches to better understand sebaceous (immuno)biology.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Frontiers in Immunology. - 12 (2021), p. 1-16. -
További szerzők:	Fazekas Fruzsina (1993-) (biológus) Póliska Szilárd (1978-) (biológus) Gregus Andrea (1980-) (biológus) Janka Eszter Anna (1989-) (bőrgyógyász, népegészségügyi szakember) Dull Katalin (1983-) (molekuláris biológus, genetikus) Szegedi Andrea (1964-) (bőrgyógyász) Zouboulis, Christos C. (1960-) (bőrgyógyász) Kovács Dóra (1988-) (Biológus)
Pályázati támogatás:	FK-132296 OTKA K-128250 OTKA Bolyai ösztöndíj MTA ÚNKP-20-5 Egyéb GINOP-2.3.2-15-2016-00005 GINOP
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