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001-es BibID:	BIBFORM061540
Első szerző:	Uray Iván Péter (1970-)
Cím:	Left ventricular unloading alters receptor tyrosine kinase expression in the failing human heart / Iván P. Uray, John H. Connelly, Vilmos Thomázy, Gregory L. Shipley, William K. Vaughn, O. Howard Frazier, Heinrich Taegtmeyer, Peter J. A. Davies
Dátum:	2002
ISSN:	1053-2498
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal Of Heart And Lung Transplantation. - 21 : 7 (2002), p. 771-782. -
További szerzők:	Connelly, John H. Thomázy Vilmos Shipley, Gregory L. Vaughn, William K. Frazier, O. Howard Taegtmeyer, Heinrich Davies, Peter J. A.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM061568
Első szerző:	Uray Iván Péter (1970-)
Cím:	Altered expression of tyrosine kinase receptors Her2/neu and GP130 following left ventricular assist device (LVAD) placement in patients with heart failure / I. P. Uray, J. H. Connelly, O. Frazier, H. Taegtmeyer, P. J. Davies
Dátum:	2001
ISSN:	1053-2498
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:	Journal Of Heart And Lung Transplantation. - 20 : 2 (2001), p. 210. -
További szerzők:	Connelly, John H. Frazier, O. Howard Taegtmeyer, Heinrich Davies, Peter J. A.
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001-es BibID:	BIBFORM061541
Első szerző:	Uray Iván Péter (1970-)
Cím:	Mechanical unloading increases caveolin expression in the failing human heart / Ivan P. Uray, John H. Connelly, O. Howard Frazier, Heinrich Taegtmeyer, Peter J. A. Davies
Dátum:	2003
ISSN:	0008-6363
Megjegyzések:	Objective: Implantation of a left ventricular assist device (LVAD) in the failing human heart initiates structural and functional changes termed reverse remodeling. Mechanical unloading improves cardiac adrenergic responsiveness and lipid metabolism, processes regulated by caveolar function. We tested the hypothesis that mechanical unloading alters the expression of caveolins and these changes are linked to altered expression of markers of reverse remodeling. Methods: Paired human myocardial samples were obtained from patients who received an LVAD as a bridge to cardiac transplantation. Transcript levels were measured using real-time Q-RT-PCR in RNA prepared from 34 pairs of formalin-fixed myocardial tissue blocks. Caveolin-1 and -3 protein levels were determined from frozen tissue (n55) by Western blots. Caveolin-3 localization was demonstrated by immunohistochemistry. Results: Caveolin-1 protein levels were upregulated in all LVAD-patients after mechanical unloading (P50.002). Caveolin-1 mRNA was increased in 76% of the patients (n534, P,0.001). Larger induction of caveolin-1 was associated with greater suppression of ANF. Caveolin-3 transcript levels increased in 82% of the cohort, along with a 2.5-fold induction of caveolin-2. Sarcolemmal caveolin-3 staining was increased after LVAD-support, although no change in total caveolin-3 protein was detected. The mRNA levels of the caveolin-associated CD36 also increased with unloading. Patients with ischemic cardiomyopathy showed greater induction of CD36 (P,0.05) than non-ischemic cases, as well as highly correlated changes in the expression of caveolin isoforms. Conclusion: Mechanical unloading induces the expression of caveolins and CD36. The induction of caveolin-1 and the reciprocal suppression of ANF suggest that the changes in the expression of both genes are linked to decreased hemodynamic load. Enhanced caveolin expression during mechanical unloading of failing human hearts may be a part of the reverse remodeling of lipid metabolism, nitric oxide production and adrenergic signaling.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Cardiomyopathy Heart failure Gene expression Remodeling Transplantation
Megjelenés:	Cardiovascular Research. - 59 : 1 (2003), p. 57-66. -
További szerzők:	Connelly, John H. Frazier, O. Howard Taegtmeyer, Heinrich Davies, Peter J. A.
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