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001-es BibID:	BIBFORM077848
035-os BibID:	(PMID)30101988 (Scopus)85052790800 (WOS)000450406900003
Első szerző:	Guttman András (vegyészmérnök)
Cím:	Authors' Reply to the Commentary in the journal of Electrophoresis regarding "The effect of simulated space radiation on the N-glycosylation of human immunoglobulin G1" by J.J. Bevelacqua and S.M.J. Mortazavi / Andras Guttman, Szabolcs Szilasi, Boglarka Donczo, Mate Szarka
Dátum:	2018
ISSN:	0173-0835 1522-2683
Megjegyzések:	By reading the commentary of Bevelacqua and Mortazavi regarding our recently published paper titled as "The effect of simulated space radiation on the N?glycosylation of human immunoglobulin G1"[1], we are afraid that some of the important messaging aspects of our paper might not have been articulated adequately to be fully understandable for a wider audience, i.e., not separation scientists. First, we should clarify that complete space radiation description was not the goal of this paper. In this short communication we only intended to show the effect of simulated space radiation on the conserved N?glycosylation of IgG1 molecules with the goal to understand if they could be utilized as disease biomarkers during longer space missions, similar to that as they are currently used here on Earth, e.g. for autoimmune disease or aging markers. Therefore, no discussion was given about any biological effects either as our study only investigated the qualitative effects of proton irradiation on the N?linked carbohydrate decomposition of IgG type 1 molecules with the intent of suggesting them to be used as biomarkers during deep space travel. Radioadaptation was never an issue in our study for the reasons mentioned above.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok szerkesztői levél folyóiratcikk Glycans IgG Space
Megjelenés:	Electrophoresis. - 39 : 22 (2018), p. 2851-2853. -
További szerzők:	Szilasi Szabolcs Döncző Boglárka (1987-) (biológiatanár-földrajztanár) Szarka Máté (1990-)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM077851
035-os BibID:	(Scopus)85056587326 (WOS)000450406900006
Első szerző:	Szarka Máté
Cím:	The effect of simulated space radiation on the N-glycosylation of human immunoglobulin G1 / Mate Szarka, Szabolcs Szilasi, Boglarka Donczo, Daniel Sarkozy, Istvan Rajta, Andras Guttman
Dátum:	2018
ISSN:	0173-0835 1522-2683
Megjegyzések:	On a roundtrip to Mars, astronauts are expectedly exposed to an approximate amountof radiation that exceeds the lifetime limits on Earth. This elevated radiation dose ismainly due to Galactic Cosmic Rays and Solar Particle Events. Specific patterns of theN-glycosylation of human Igs have already been associated with various ailments such asautoimmune diseases, malignant transformation, chronic inflammation, and ageing. Thefocus of our work was to investigate the effect of low-energy proton irradiation on the IgGN-glycosylation profile with the goal if disease associated changes could be detected duringspace travel and not altered by space radiation. Two ionization sources were used duringthe experiments, a Van de Graaff generator for the irradiation of solidified hIgG samples invacuum, and a Tandetron accelerator to irradiate hIgG samples in aqueous solution form.Structural carbohydrate analysis was accomplished by CE with laser induced fluorescentdetection to determine the effects of simulated space radiation onN-glycosylation of hIgG1samples. Our results revealed that even several thousand times higher radiation doses thatof astronauts can suffer during long duration missions beyond the shielding environmentof Low Earth Orbit, no changes were observed in hIgG1N-glycosylation. Consequently,changes inN-linked carbohydrate profile of IgG1 can be used as molecular diagnostic toolsin space.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Electrophoresis. - 39 : 22 (2018), p. 2872-2876. -
További szerzők:	Szilasi Szabolcs Döncző Boglárka (1987-) (biológiatanár-földrajztanár) Sárközy Dániel (1993-) (PhD hallgató) Rajta István (1970-) (fizikus) Guttman András (1954-) (vegyészmérnök)
Pályázati támogatás:	NKFIH K 116263 NKFIH NKFIH NN127062 NKFIH BIONANO GINOP-2.3.2-15-2016-00017 GINOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: