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001-es BibID:BIBFORM088317
035-os BibID:(cikkazonosító)e1007864 (WoS)000538053200045 (Scopus)85086089732
Első szerző:Horváth Attila (programtervező informatikus)
Cím:Sequence-based prediction of protein binding mode landscapes / Attila Horvath, Marton Miskei, Viktor Ambrus, Michele Vendruscolo, Monika Fuxreiter
Dátum:2020
ISSN:1553-7358
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:PLoS Computational Biology. - 16 : 5 (2020), p. 1-19. -
További szerzők:Miskei Márton (1978-) (molekuláris biológus, genetikus) Ambrus Viktor Attila (1989-) (biotechnológus) Vendruscolo, Michele Fuxreiter Mónika (1969-) (kutató vegyész)
Pályázati támogatás:GINOP-2.3.2-15-2016-00044
GINOP
Internet cím:Szerző által megadott URL
DOI
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001-es BibID:BIBFORM031420
035-os BibID:WOS:000263923800012
Első szerző:Tóth-Petróczy Ágnes
Cím:Malleable machines in transcription regulation : the mediator complex / Ágnes Tóth-Petróczy, Christopher J. Oldfield, István Simon, Yuichiro Takagi, A. Keith Dunker, Vladimir N. Uversky, Mónika Fuxreiter
Dátum:2008
ISSN:1553-734X
Megjegyzések:The Mediator complex provides an interface between gene-specific regulatory proteins and the general transcription machinery including RNA polymerase II (RNAP II). The complex has a modular architecture (Head, Middle, and Tail) and cryoelectron microscopy analysis suggested that it undergoes dramatic conformational changes upon interactions with activators and RNAP II. These rearrangements have been proposed to play a role in the assembly of the preinitiation complex and also to contribute to the regulatory mechanism of Mediator. In analogy to many regulatory and transcriptional proteins, we reasoned that Mediator might also utilize intrinsically disordered regions (IDRs) to facilitate structural transitions and transmit transcriptional signals. Indeed, a high prevalence of IDRs was found in various subunits of Mediator from both Saccharomyces cerevisiae and Homo sapiens, especially in the Tail and the Middle modules. The level of disorder increases from yeast to man, although in both organisms it significantly exceeds that of multiprotein complexes of a similar size. IDRs can contribute to Mediator's function in three different ways: they can individually serve as target sites for multiple partners having distinctive structures; they can act as malleable linkers connecting globular domains that impart modular functionality on the complex; and they can also facilitate assembly and disassembly of complexes in response to regulatory signals. Short segments of IDRs, termed molecular recognition features (MoRFs) distinguished by a high protein-protein interaction propensity, were identified in 16 and 19 subunits of the yeast and human Mediator, respectively. In Saccharomyces cerevisiae, the functional roles of 11 MoRFs have been experimentally verified, and those in the Med8/Med18/Med20 and Med7/Med21 complexes were structurally confirmed. Although the Saccharomyces cerevisiae and Homo sapiens Mediator sequences are only weakly conserved, the arrangements of the disordered regions and their embedded interaction sites are quite similar in the two organisms. All of these data suggest an integral role for intrinsic disorder in Mediator's function.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:PLoS Computational Biology. - 4 : 12 (2008), p. e1000243. -
További szerzők:Oldfield, Christopher J. Simon István Takagi, Yuichiro Dunker, A. Keith Uversky, Vladimir N. Fuxreiter Mónika (1969-) (kutató vegyész)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
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