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001-es BibID:	BIBFORM073584
Első szerző:	Ács Zsuzsanna
Cím:	Rat milk stimulates pituitary growth hormone secretion of neonatal pituitaries in vitro / Ács Zs., Kacsóh B., Veress Z., Tóth B. E.
Dátum:	1988
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Life sciences 42 : 23 (1988), p. 2315-2321. -
További szerzők:	Kacsóh Bálint Veress Zoltán Tóth E. Béla (1960-) (orvos)
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001-es BibID:	BIBFORM073570
Első szerző:	Kacsóh Bálint
Cím:	In vitro control of prolactin (PRL) and growth hormone secretion of neonatal rat pituitary glands : effects of ovine PRL, salmon calcitonin, endothelin-3, angiotensin II, bromocryptine and somatostatin / Kacsóh B., Tóth B. E., Avery L. M., Grosvenor C. E.
Dátum:	1993
Megjegyzések:	Bromocryptine potently decreased prolactin (PRL) secretion of pituitary glands of 2-day-old rats in vitro (up to 85% inhibition; ED50 between 0.1 and 1.0 nM) without altering the bioactivity to immunoreactivity (B/I) ratio. Bromocryptine tended to suppress growth hormone (GH) secretion although the effect did not reach statistical significance. Angiotensin-II (A-II; 1-1000 nM) stimulated PRL secretion in a dose-dependent manner without affecting secretion of GH. The B/I ratio of PRL secreted in response to A-II was increased. Somatostatin (SRIF) had no effect on PRL secretion but inhibited GH secretion in a dose-dependent manner; significant inhibition (50%) was observed at 100 nM. A 6-h exposure to ovine PRL (oPRL) in concentrations equipotent with 1.2-120 ng/ml rat PRL (rPRL) in the Nb2 bioassay had no effect on immunoreactive rPRL secretion. Salmon calcitonin (sCT) and endothelin-3 (ET-3; 0.1-100 nM) failed to inhibit secretion of PRL or GH. PRL secretion was slightly stimulated by sCT with no apparent dose-response relationship. The present findings suggest that neonatal pituitary glands do not display autoregulation of PRL secretion, and sCT and ET-3 (either endogenous or milk-derived) may not function as PRL inhibiting factors in 2-day-old pups. Thus, the receptors of PRL, sCT and ET-3 on lactotropes, or their functional coupling with inhibition of basal PRL secretion, occur at a later stage of development. The specificity of the PRL releasing factor (PRF) activity of A-II at this age is unique for established PRFs and might reflect a physiological function of PRL in osmoregulation. The increased B/I ratio of PRL secreted in response to A-II may be due to the release of specific PRL variants, and might be a sign of functional heterogeneity among lactotropes. The differential sensitivity of PRL and GH to the applied secretagogues suggests that the intracellular regulation of PRL and GH are compartmentalized in the mammosomatotrope cell.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Life Sciences 57 : 2 (1993), p. 195-203. -
További szerzők:	Tóth E. Béla (1960-) (orvos) Avery, Leann M. Grosvenor, Clark E.
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001-es BibID:	BIBFORM073543
Első szerző:	Wenger Tibor
Cím:	Effects of anandamide (endogen cannabinoid) on anterior pituitary hormone secretion in adult ovariectomized rats / Wenger T., Tóth B. E., Martin B. R.
Dátum:	1995
ISSN:	0024-3205
Megjegyzések:	It has been shown that the main psychoactive component of marihuana, delta 9-tetrahydrocannabinol (THC) has mainly inhibitory effects on pituitary luteinizing hormone (LH), prolactin (PRL) and growth hormone (GH) and has no or little effect on follicle stimulating hormone (FSH) secretion. Recently the purification and availability of the putative endogenous ligand for the cannabinoid receptor, anandamide (arachidonyl ethanol-amide, anandamide) (ANA) provided us the opportunity to compare the effects of THC and ANA on the female neuroendocrine system in ovariectomized (OVX) rats. OVX was performed three weeks prior to the experimental period to avoid cyclic differences. OVX rats were injected i.p. with either THC or ANA (0.02 mg/kg.b.w./day, respectively) or vehicle for two weeks. The results show that both ANA and THC decrease serum LH level although THC with a higher degree. No significant differences were observed in serum FSH level. Both drugs decreased serum PRL. Serum GH was increased after THC administration and significantly decreased after ANA. The results indicate that ANA and THC alter pituitary hormone secretion, mainly by inhibitory action. The site of action requires further investigations.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban Prolactin Prolactin-releasing factors Development
Megjelenés:	Life Sciences 56 : 23-24 (1995), p. 2057-2063. -
További szerzők:	Tóth E. Béla (1960-) (orvos) Martin, Billy R.
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001-es BibID:	BIBFORM073603
Első szerző:	Wenger Tibor
Cím:	The effects of cannabinoids on the regulation of reproduction / Tibor Wenger, Béla E. Tóth, Christian Juanéda, Jean Leonardelli, Gérard Tramu
Dátum:	1999
ISSN:	0024-3205
Megjegyzések:	It has been shown that the main psychoactive component of marihuana, ?9tetrahydrocannabinol (THC) has mainly inhibitory effects on the regulation of reproduction. Recently, the purification and availability of the endogenous ligand of the cannabinoid receptor, arachidonyl ethanolamide, anandamide, (ANA) and its specific long lasting antagonist, the SR 141716 (SR) provided us the opportunity to compare the effects of THC and ANA on the neuroendocrine regulation of reproduction. ANA decreases serum luteinizing hormone (LH) and prolactin (PRL) levels in rats of both sexes. It has no action on serum follicle stimulating hormone (FSH) level. When ANA was administered to pregnant rats it resulted in an increase of the duration of pregnancy and in the frequency of stillbirths. The postnatal development of hypothalamo-pituitary axis in offspring was temporarily inhibited. In conclusion, we found that exogenous and endogenous cannabinoids have only slightly different effects on the reproductive parameters. These effects may occur via the central cannabinoid receptor. It is possible that the sites of action are at both hypothalamic and pituitary levels. The results further support the view that ANA may be a central neurotransmitter or neuromodulator.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Life Sciences 65 : 6-7 (1999), p. 695-701. -
További szerzők:	Tóth E. Béla (1960-) (orvos) Juanéda, Christian Leonardelli, Jean Tramu, Gérard
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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