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1.

001-es BibID:BIBFORM073589
Első szerző:Bodnár Ibolya
Cím:Stress- as well as suckling-induced prolactin release is blocked by a structural analogue of the putative hypophysiotrophic prolactin-releasing factor, salsolinol / I. Bodnar, B. Mravec, L. Kubovcakova, E. B. Toth, F. Fulop, M. I. K. Fekete, R. Kvetnansky, G. M. Nagy
Dátum:2004
ISSN:0953-8194
Megjegyzések:Prolactin is secreted from the anterior lobe of the pituitary gland in response both to suckling and to stress. We recently observed that 1?methyl?6,7?dihydroxy?1,2,3,4?tetrahydroisoquinoline (salsolinol), produced in the neurointermediate lobe of the pituitary gland, as well as in the medial basal hypothalamus, can selectively release prolactin from the anterior pituitary. Therefore, it has been proposed that salsolinol is a putative endogenous prolactin?releasing factor (PRF). Here, we report that one structural analogue of salsolinol, 1?methyl?3,4?dihydroisoquinoline (1MeDIQ), can block salsolinol?induced release of prolactin, but does not affect prolactin release in response to thyrotropin releasing hormone (TRH), ??methyl?p?tyrosine (?MpT) (an inhibitor of tyrosine hydroxylase), domperidone (a D2 dopamine receptor antagonist), or 5?hydroxytryptophan (5?HTP), a precursor of serotonin). 1MeDIQ profoundly inhibited suckling?, immobilization?, as well as formalin?stress induced prolactin release without any influence on corticosterone secretion. The 1MeDIQ?induced reduction in prolactin response to immobilization stress was dose?dependent. These results suggest that salsolinol can play a pivotal role in the regulation of prolactin release induced by either physiological (suckling) or environmental (stress) stimuli.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Neuroendocrinology 16 : 3 (2004), p. 208-213. -
További szerzők:Mravec, B. Kubovcakova, L. Tóth E. Béla (1960-) (orvos) Fülöp Ferenc Fekete I. K. Márton Kvetnansky, R. Nagy György M.
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2.

001-es BibID:BIBFORM073592
Első szerző:Bodnár Ibolya
Cím:Brain structures mediating the suckling stimulus-induced release of prolactin / I. Bodnár, Zs. Bánky, B. E. Tóth, G. M. Nagy, B. Halász
Dátum:2002
ISSN:0953-8194
Megjegyzések:Suckling?induced prolactin release is a widely studied neuroendocrine reflex, comprising a neural afferent and a humoral efferent component. The information on the brain structures involved in this reflex is fairly limited. The present studies focused on this question. The following hypothalamic interventions were made in lactating rats and the dams were tested for the suckling?induced prolactin response: (i) unilateral or (ii) bilateral frontal cuts at the level of the anterior and posterior hypothalamus; (iii) administration of 5,7?dihydroxytryptamine or (iv) 6?hydroxydopamine into the hypothalamic paraventricular nucleus (PVN) to destroy serotonergic and catecholaminergic innervation of the cell group, respectively; (v) lesion of the medial subdivision of the PVN; and (vi) horizontal knife cuts below the PVN. Bilateral posterior and bilateral or unilateral anterior frontal cuts caused blockade of the suckling?induced release of prolactin. Likewise, most dams receiving 5,7?dihydroxytryptamine in the PVN did not respond to the suckling stimulus. Immunocytochemistry revealed that, in those rats which did not show a rise in plasma prolactin, there were almost no serotonergic fibres and terminals in the PVN, while in dams which exhibited a response, numerous serotonergic elements were evident. 6?Hydroxydopamine treatment did not cause significant alteration in the prolactin response. Lesion of the medial, largely parvocellular subdivision of the PVN, or horizontal knife cuts below this cell group, blocked the hormone response. The findings demonstrate for the first time that: (i) interruption of the connections between the brain stem and the hypothalamus interferes with the prolactin response to the suckling stimulus; (ii) serotonergic fibres terminating in the hypothalamic PVN are involved in the mediation of the suckling stimulus; and (iii) within the PVN, neurones in the medial, largely parvocellular subdivision of the cell group take part in the transfer of the neural signal, eventually inducing prolactin release.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Neuroendocrinology 14 : 5 (2002), p. 384-396. -
További szerzők:Bánky Zsuzsanna Tóth E. Béla (1960-) (orvos) Nagy György M. Halász Béla
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3.

001-es BibID:BIBFORM073546
Első szerző:Kacsóh Bálint
Cím:Neuroendocrine control of immunoreactive growth hormone and bioactive prolactin secretion in neonatal rats : ontogeny and interactions between the serotonergic, cholinergic and alpha 2-adrenergic systems / Kacsóh B., Tóth B. E., Grosvenor C. E.
Dátum:1993
ISSN:0028-3835
Megjegyzések:The effects of the alpha 2-agonist clonidine (CLO), the serotonin (5-HT) precursor 5-hydroxy-L-tryptophan (5-HTP), the 5-HT2/histamine (H1) antagonist cyproheptadine (CYPRO), the muscarinic cholinergic antagonist atropine (ATR), and an affinity-purified polyclonal anti-rat growth hormone-releasing hormone (rGHRH) immunoglobulin on serum concentrations of growth hormone (GH) and prolactin (PRL) were tested in 2- and 10-day-old litter-mate rat pups. Serum levels of GH and PRL were detected in RIA and Nb2 lymphoma bioassay, respectively. The effects of two different drugs either alone or in combination with each other were evaluated by two-factor analysis of variance. The data indicated that secretion of GH and PRL was regulated by alpha 2-adrenergic, serotonergic and cholinergic mechanisms; the pathways regulating the two hormones, however, were distinct. 5-HTP stimulated GH secretion as early as day 2 postpartum via cholinergic mechanisms not involving GHRH; this pathway was also present in 10-day-old pups. An additional serotonergic pathway was functional in 10-day-old pups which mediated CLO-induced release of GH, and did not include cholinergic transmission.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Prolactin Prolactin-releasing factors Development
Megjelenés:Neuroendocrinology 57 : 2 (1993), p. 195-203. -
További szerzők:Tóth E. Béla (1960-) (orvos) Grosvenor, Clark E.
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4.

001-es BibID:BIBFORM073576
Első szerző:Kacsóh Bálint
Cím:Thyrotropin-releasing hormone mediates growth hormone release induced by milk and nursing in neonatal rats / Kacsóh B., Tóth B. E., Grosvenor C. E.
Dátum:1992
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Neuroendocrinology 4 : 6 (1992), p. 663-672. -
További szerzők:Tóth E. Béla (1960-) (orvos) Grosvenor, Clark E.
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5.

001-es BibID:BIBFORM073542
Első szerző:Nemeskéri Ágnes
Cím:Prolactin-synthesizing and prolactin-releasing activity of fetal and early postnatal rat pituitaries : in vivo and in vitro studies using RIA, reverse hemolytic plaque assay and immunocytochemistry / Nemeskéri Ágnes, Ács Zsuzsanna, Tóth Béla E.
Dátum:1995
ISSN:0028-3835
Megjegyzések:In vivo and in vitro prolactin (PRL)-synthesizing and PRL?releasing activity of fetal (days 12?22) and early postnatal (days 1?10 after birth) rat pituitaries were studied by means of radioimmunoassay (RIA), reverse hemolytic plaque assay and immunocytochemistry. Using RIA, PRL could first be detected, both in the pituitary and in the serum, on day 17 of fetal development. From this day on, pituitary PRL gradually increased, the rise was particularly marked during the postnatal period and became depressed for the first 10 days of postnatal life. On fetal day 18 12-15 % of monodispersed pituitary cells displayed PRL immuno-positivity, but only 3-5% of PRL?positive cells were plaque-forming, i.e. releasedPRL. By the end of gestation 19-25% and on postnatal day 1042-45% of all pituitary cells were PRL cells and 31-35 and 15-17% of PRL?positive cells, respectively released PRL. Both pre- and postnatal PRL cells in monolayers were insensitive to TRH treatment. Pituitary primordia immunocytochemically and radioimmunologically negative for PRL (13- to 14-day-old fetal) when placed in serum-free organ culture were able to synthesize and release PRL. Fetal pituitary exhibited a highly regular increasing pattern of daily PRL release during a 7-day-culture period. Data obtained both in vivo and in vitro did not exhibit any sex differences. The present findings are consistent with all those observations suggesting an early emergence of fetal rat pituitary lactotrophs. The in vitro results support the concept that Rathke's pouch cells have a substantial degree of independence from extrapituitary regulatory actions in the expression and further progression of specific functions. This study is the first demonstrating PRL release of individual fetal lactotrophs from day 18 of intra-uterine life onwards and the ontogenetic change in the percentage of functionally active and inactive subpopulations of PRL cells. Further, the observations are in line with the assumption that the dopaminergic inhibition of PRL release may start in early postnatal life.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Prolactin Prolactin-releasing factors Development
Megjelenés:Neuroendocrinology 61 : 6 (1995), p. 687-694. -
További szerzők:Ács Zsuzsanna Tóth E. Béla (1960-) (orvos)
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6.

001-es BibID:BIBFORM031973
Első szerző:Tóth E. Béla (orvos)
Cím:Salsolinol is putative endogenous Neuro-intermediate lobe prolactin-releasing factor / Tóth B. E., Homicskó K., Radnai B., Maruyama W., DeMaria J. E., Vecsernyés M., Fekete M. I. K., Fülöp F., Naoi M., Freeman M. E., Nagy G. M.
Dátum:2001
ISSN:0953-8194
Megjegyzések:The isolation and identification of a prolactin-releasing factor (PRF) from the neuro-intermediate lobe of the pituitary gland has been pursued for over a decade. Using high-pressure liquid chromatography with electrochemical detection (HPLC-ECD) and gas chromatography/mass spectrometry (GC/MS) (R)-salsolinol (SAL) (a dopamine-related stereo-specific tetrahydroisoquinoline) was found to be present in neuro-intermediate lobe as well as median eminence extracts of male, intact-, and ovariectomized female rats. Moreover, analysis of SAL concentrations in neuro-intermediate lobe revealed parallel increases with plasma prolactin in lactating rats exposed to a brief (10 min) suckling stimulus following 4-h separation. SAL appears to be a selective and potent stimulator of prolactin secretion in vivo and it was without effect on the secretion of other pituitary hormones. We have also found that SAL can elevate prolactin release, although to a lesser extent, in pituitary cell cultures as well as in hypophysectomized rats bearing anterior lobe transplants under the kidney capsule. Lack of interference of SAL with [3H]-spiperone binding to AP homogenates indicates that SAL does not act at the dopamine D2 receptor. Moreover, [3H]-SAL binds specifically to homogenate of AL as well as neuro-intermediate lobe obtained from lactating rats. Taken together, our data clearly suggest that SAL is synthesized in situ and this compound can play a role in the regulation of pituitary prolactin secretion.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Neuroendocrinology 13 : 12 (2001), p. 1042-1050. -
További szerzők:Homicskó Krisztián Gy. Radnai Balázs Maruyama W. DeMaria, Jamie E. Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Fekete I. K. Márton Fülöp Ferenc Naoi, M. Freeman, Marc E. Nagy György M.
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