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001-es BibID:	BIBFORM073659
Első szerző:	Takács István
Cím:	Randomized clinical trial to comparing efficacy of daily, weekly and monthly administration of vitamin D3 / István Takács, Béla E. Tóth, László Szekeres, Boglárka Szabó, Bence Bakos, Péter Lakatos
Dátum:	2016
ISSN:	1355-008X 1559-0100
Megjegyzések:	The comparative efficacy and safety profiles of selected daily 1000?IU, weekly 7000?IU and monthly 30,000?IU vitamin D 3?not previously investigated?will be evaluated. Here, a prospective, randomized clinical trial, comparing efficacy and safety of a daily single dose of 1000?IU (group A) to a once-weekly 7000?IU dose (group B), or monthly 30,000?IU dose (group C) of vitamin D3. The present study is a controlled, randomized, open-label, multicenter clinical trial, 3? months in duration. Sixty-four adult subjects with vitamin D deficiency (25OHD<20?ng/ml), were included according to the inclusion and exclusion criteria. Dose-responses for increases in serum vitamin 25OHD were statistically equivalent for each of the three groups: A, B and C. Outcomes were 13.0???1.5; 12.6???1.1 and 12.9???0.9?ng/ml increases in serum 25OHD per 1000?IU, daily, weekly and monthly, respectively. The treatment of subjects with selected doses restored 25OHD values to levels above 20?ng/ml in all groups. Treatment with distinct administration frequency of vitamin D3 did not exhibit any differences in safety parameters. The daily, weekly and monthly administrations of daily equivalent of 1000?IU of vitamin D3 provide equal efficacy and safety profiles.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Endocrine 55 : 1 (2016), p. 60-65. -
További szerzők:	Tóth E. Béla (1960-) (orvos) Szekeres László Szabó Boglárka Bakos Bence Lakatos Péter (belgyógyász)
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