CCL

Összesen 18 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM073589
Első szerző:Bodnár Ibolya
Cím:Stress- as well as suckling-induced prolactin release is blocked by a structural analogue of the putative hypophysiotrophic prolactin-releasing factor, salsolinol / I. Bodnar, B. Mravec, L. Kubovcakova, E. B. Toth, F. Fulop, M. I. K. Fekete, R. Kvetnansky, G. M. Nagy
Dátum:2004
ISSN:0953-8194
Megjegyzések:Prolactin is secreted from the anterior lobe of the pituitary gland in response both to suckling and to stress. We recently observed that 1?methyl?6,7?dihydroxy?1,2,3,4?tetrahydroisoquinoline (salsolinol), produced in the neurointermediate lobe of the pituitary gland, as well as in the medial basal hypothalamus, can selectively release prolactin from the anterior pituitary. Therefore, it has been proposed that salsolinol is a putative endogenous prolactin?releasing factor (PRF). Here, we report that one structural analogue of salsolinol, 1?methyl?3,4?dihydroisoquinoline (1MeDIQ), can block salsolinol?induced release of prolactin, but does not affect prolactin release in response to thyrotropin releasing hormone (TRH), ??methyl?p?tyrosine (?MpT) (an inhibitor of tyrosine hydroxylase), domperidone (a D2 dopamine receptor antagonist), or 5?hydroxytryptophan (5?HTP), a precursor of serotonin). 1MeDIQ profoundly inhibited suckling?, immobilization?, as well as formalin?stress induced prolactin release without any influence on corticosterone secretion. The 1MeDIQ?induced reduction in prolactin response to immobilization stress was dose?dependent. These results suggest that salsolinol can play a pivotal role in the regulation of prolactin release induced by either physiological (suckling) or environmental (stress) stimuli.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Neuroendocrinology 16 : 3 (2004), p. 208-213. -
További szerzők:Mravec, B. Kubovcakova, L. Tóth E. Béla (1960-) (orvos) Fülöp Ferenc Fekete I. K. Márton Kvetnansky, R. Nagy György M.
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

2.

001-es BibID:BIBFORM073592
Első szerző:Bodnár Ibolya
Cím:Brain structures mediating the suckling stimulus-induced release of prolactin / I. Bodnár, Zs. Bánky, B. E. Tóth, G. M. Nagy, B. Halász
Dátum:2002
ISSN:0953-8194
Megjegyzések:Suckling?induced prolactin release is a widely studied neuroendocrine reflex, comprising a neural afferent and a humoral efferent component. The information on the brain structures involved in this reflex is fairly limited. The present studies focused on this question. The following hypothalamic interventions were made in lactating rats and the dams were tested for the suckling?induced prolactin response: (i) unilateral or (ii) bilateral frontal cuts at the level of the anterior and posterior hypothalamus; (iii) administration of 5,7?dihydroxytryptamine or (iv) 6?hydroxydopamine into the hypothalamic paraventricular nucleus (PVN) to destroy serotonergic and catecholaminergic innervation of the cell group, respectively; (v) lesion of the medial subdivision of the PVN; and (vi) horizontal knife cuts below the PVN. Bilateral posterior and bilateral or unilateral anterior frontal cuts caused blockade of the suckling?induced release of prolactin. Likewise, most dams receiving 5,7?dihydroxytryptamine in the PVN did not respond to the suckling stimulus. Immunocytochemistry revealed that, in those rats which did not show a rise in plasma prolactin, there were almost no serotonergic fibres and terminals in the PVN, while in dams which exhibited a response, numerous serotonergic elements were evident. 6?Hydroxydopamine treatment did not cause significant alteration in the prolactin response. Lesion of the medial, largely parvocellular subdivision of the PVN, or horizontal knife cuts below this cell group, blocked the hormone response. The findings demonstrate for the first time that: (i) interruption of the connections between the brain stem and the hypothalamus interferes with the prolactin response to the suckling stimulus; (ii) serotonergic fibres terminating in the hypothalamic PVN are involved in the mediation of the suckling stimulus; and (iii) within the PVN, neurones in the medial, largely parvocellular subdivision of the cell group take part in the transfer of the neural signal, eventually inducing prolactin release.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Neuroendocrinology 14 : 5 (2002), p. 384-396. -
További szerzők:Bánky Zsuzsanna Tóth E. Béla (1960-) (orvos) Nagy György M. Halász Béla
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

3.

001-es BibID:BIBFORM030625
Első szerző:Bodnár Ibolya
Cím:Effect of neonatal treatment with monosodium glutamate on dopaminergic and L-DOPA-ergic neurons of the medial basal hypothalamus and on prolactin and MSH secretion of rats / Ibolya Bodnár, Pál Göőz, Hitoshi Okamura, Béla E. Tóth, Miklós Vecsernyés, Béla Halász, György M. Nagy
Dátum:2001
ISSN:0361-9230
Megjegyzések:The effect of neonatal treatment with monosodium L-glutamate (MSG) on the dopaminergic systems of the medial basal hypothalamus has been investigated using tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) immunocytochemistry. Changes in plasma levels of prolactin (PRL) and alpha-melanocyte-stimulating hormone (MSH) have also been determined in intact and in MSG-treated rats after inhibition of TH by alpha-methyl-p-tyrosine (alpha-MpT) or without inhibition of enzyme activity. Monosodium glutamate resulted in a 40% reduction in the number of TH immunopositive tuberoinfundibular neurons, but no change in the number of AADC-positive tuberoinfundibular nerve cells, indicating that this reduction has occurred mainly in TH-positive but AADC-negative elements, i.e., in L-DOPA-ergic neurons. In contrast, MSG did not cause changes in the number of TH and AADC immunoreactive neurons of the periventriculohypophysial and tuberohypophysial dopaminergic systems, and it did not influence basal plasma PRL levels. alpha-methyl-p-tyrosine has increased plasma PRL concentrations in both control and MSG-treated rats of both sexes, but significantly higher responses were detected in females. None of the treatments had any effect on plasma MSH level. These findings suggest that MSG affects primarily L-DOPA-ergic neurons located in the ventrolateral part of the arcuate nucleus, but not dopaminergic neurons situated in the dorsomedial part of the arcuate nucleus; neither PRL nor MSH secretion is altered by MSG; a significant sex difference exists in the pituitary PRL response to inhibition of TH, and this response is not affected by MSG.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
arcuate nucleus
tyrosine hydroxylase
aromatic L-amino acid decarboxylase
immunocytochemistry
Megjelenés:Brain Research Bulletin 55 : 6 (2001), p. 767-774. -
További szerzők:Göőz Pál Okamura, Hitoshi Tóth E. Béla (1960-) (orvos) Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Halász Béla Nagy György M.
Pályázati támogatás:T-30748
OTKA
T-029004
OTKA
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

4.

001-es BibID:BIBFORM073598
Első szerző:Gadó Klára
Cím:Elevated levels of serum prolactin in patients with advanced multiple myeloma / Klára Gadó, Éva Rimanóczi, Ágnes Hasitz, Gábor Gigler, Béla E. Tóth, György M. Nagy, Katalin Pálóczi, Gyula Domján
Dátum:2001
ISSN:1021-7401
Megjegyzések:The role of prolactin in immunoregulation and normal hemopoiesis is well known. However, prolactin also seems to be involved in the pathomechanism of malignancies and autoimmune diseases. Elevated serum prolactin levels were reported in patients with malignant lymphoma, colon and breast carcinoma, systemic lupus erythematosus and rheumatoid arthritis. Recently we demonstrated prolactin immunostaining in bone marrow cells of patients with multiple myeloma. Design and Methods: Serum prolactin levels of 56 patients with multiple myeloma, as well as serum ?2-microglobulin, and interleukin-6 concentrations were determined in this study. Results: Patients with advanced disease showed a significant increase in serum prolactin concentration, while patients with a clinical stage of I and II, and also control patients had normal values. The concentration of serum ?2-microglobulin and interleukin-6 changed in parallel with that of serum prolactin in patients with multiple myeloma. Determining serum prolactin levels several times during the disease process in a given patient clearly showed that the prolactin concentration was increasing during the disease progression. Interpretation and Conclusions: Our results indicate a role of prolactin in disease progression in multiple myeloma.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Neuroimmunomodulation 9 : 4 (2001), p. 231-236. -
További szerzők:Rimanóczi Éva Hasitz Ágnes Gigler Gábor Tóth E. Béla (1960-) (orvos) Nagy György M. Pálóczy Katalin Domján Gyula
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

5.

001-es BibID:BIBFORM073590
Első szerző:Góth Miklós
Cím:Physiological and pathological angiogenesis in the endocrine system / Miklós I. Góth, Erika Hubina, Stefanos Raptis, György M. Nagy, Béla E. Tóth
Dátum:2003
ISSN:1059-910X
Megjegyzések:Formation of new blood vessels occurs in many physiological states (during development of the embryo, cycling changes of the female reproductive tract), as well as in pathological processes (such as diabetic retinopathy and wound healing). Angiogenesis has been shown to be related to tumor formation, prognosis, and response to treatment in many tumor types. Intratumoral microvessels can be related to tumor behavior or hormone secretion in different endocrine tumors. For example, invasive prolactinomas are more vascular than noninvasive adenomas; a surgical approach is more successful in macroprolactinomas with lower microvessel density. A higher number of microvessels have been found in papillary thyroid carcinomas during recurrences. A correlation between microvessel count and prognosis in papillary and medullary thyroid carcinomas has been suggested. Several stimulating and inhibiting factors involved in the regulation of angiogenesis have been identified. Among them, vascular endothelial growth factor (VEGF) has been shown to be critically involved in angiogenesis and also in the neovascularization of solid tumors. Dopamine agonists (already in clinical use for prolactinomas) have potent inhibitory actions on VEGF signaling, and thus may be a new tool in antiangiogenic therapy. Secretion of VEGF in the great majority of human pituitary adenomas is inhibited by dexamethasone. This suggests that glucocorticoids can be considered in the treatment of certain pituitary tumors. The cyclic nature of angiogenesis in the female reproductive tract indicates that stimulation or inhibition of paracrine angiogenic factors may lead to new approaches for being able to influence reproductive endocrine disorders. Experimental and clinical aspects of interactions between angiogenic factors and tumor growth of the endocrine system are also discussed. Microsc. Res. Tech. 60:98?106, 2003. ? 2002 Wiley?Liss, Inc.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Microscopy Research and Technique 60 : 1 (2003), p. 98-106. -
További szerzők:Hubina Erika Raptis, Stefanos Nagy György M. Tóth E. Béla (1960-) (orvos)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

6.

001-es BibID:BIBFORM073591
Első szerző:Homicskó Krisztián Gy.
Cím:Binding site of salsolinol : its properties in different regions of the brain and the pituitary gland of the rat / Krisztián Gy. Homicskó, István Kertész, Balázs Radnai, Béla E. Tóth, Géza Tóth, Ferenc Fülöp, Márton I. K. Fekete, György M. Nagy
Dátum:2003
ISSN:0197-0186
Megjegyzések:It has been recently shown that salsolinol (SAL) is present in the hypothalamic neuroendocrine dopaminergic (NEDA) system and appears to be a selective and potent stimulator of prolactin (PRL) secretion in the rat. Furthermore, the lack of interference of SAL with -spiperone binding in the striatum and the anterior lobe (AL) of the pituitary gland has been also demonstrated. These data clearly indicate that SAL does not act at the dopamine (DA) D2 receptors, and suggest that SAL supposedly has a binding site through which the secretion of PRL may be affected. Therefore, binding of -SAL to different regions of the central nervous system (CNS) has been investigated. Specific and saturable binding has been detected in the striatum, cortex, median eminence and in the hypothalamus as well as in the AL and the neuro-intermediate lobe (NIL) of the pituitary gland. KD values of the bindings were in the nanomolar range in all tissue tested. -SAL displacing activity of several agonists and antagonists of known DA receptors have also been tested. It has been found that DA and in a lesser extent, apomorphine could displace -SAL, but other DA receptor specific ligands have not been able to affect it. Furthermore, several pharmacologically active compounds, selected on the basis of their influence on DA synthesis, transport mechanisms and signal transduction, have also been tested. Neither mazindol (a selective DA transporter inhibitor) nor clonidine (an ?2-adrenoreceptor agonist) could alter SAL binding. At the same time, l-dopa, carbidopa, benserazide and ?-methyldopa were able to displace -SAL. The possible changes in SAL binding due to physiological and pharmacological stimuli, like suckling stimulus and reserpine pretreatment (that blocks vesicular monoamine transport in DA terminals), respectively, have also been investigated. In the NIL of the pituitary gland and in the median eminence of the hypothalamus the binding decreased following 10 min of suckling stimulus compared to the binding detected in the same tissues obtained from mothers separated from their pups for 4 h and not allowed to be suckled. At the same time, there were no changes in the binding at the AL and striatum. Following reserpine pretreatment that has completely prevented PRL releasing effect of SAL, the binding was significantly augmented. These results support our assumption that SAL should have specific binding sites through which it can affect PRL secretion. Furthermore, it clearly suggests that it may regulate DAergic neurotransmission of NEDA neurons by an altered intracellular or intraterminal synthesis and/or distribution of hypophysiotropic DA.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Neurochemistry International 42 : 1 (2003), p. 19-26. -
További szerzők:Kertész István (1966-) (vegyész) Radnai Balázs Tóth E. Béla (1960-) (orvos) Tóth Géza Fülöp Ferenc Fekete I. K. Márton Nagy György M.
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

7.

001-es BibID:BIBFORM073599
Első szerző:Horváth Katalin M.
Cím:Dual role of glucocorticoids in suckling-induced prolactin secretion / Katalin M. Horváth, Zsuzsanna Bánky, Béla E. Tóth, György M. Nagy, Béla Halász
Dátum:2001
ISSN:0969-711X
Megjegyzések:The exact contribution of corticosteroids to the control of prolactin secretion in lactating rats is poorly understood. Therefore, the present studies were focused on the effect of adrenalectomy and dexamethasone treatment on the suckling-induced prolactin release. Animals were adrenalectomized on the 3rd day of lactation and tested on the 7th day of lactation. In adrenalectomized animals, the suckling stimulus failed to induce the characteristic increase in plasma prolactin levels. Dexamethasone pretreatment (400 microg/kg b.w. s.c. 24, 48, 72 h before testing) of adrenalectomized rats restored this prolactin response. The same treatment with dexamethasone given to control animals attenuated the suckling stimulus induced prolactin response. The present findings indicate that corticosteroids are essential for a basic prolactin response of lactating rats.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Endocrine. - 15 : 3 (2001), p. 287-290. -
További szerzők:Bánky Zsuzsanna Tóth E. Béla (1960-) (orvos) Nagy György M. Halász Béla
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

8.

001-es BibID:BIBFORM073600
Első szerző:Horváth Katalin M.
Cím:Effect of adrenalectomy and dexamethasone treatment on prolactin secretion of lactating rats / Katalin M. Horváth, Zsuzsanna Bánky, Béla E. Tóth, Béla Halász, György M. Nagy
Dátum:2001
ISSN:0361-9230
Megjegyzések:The contribution of corticosteroids to the control of prolactin secretion in lactating rats was investigated. The prolactin response to domperidone (20 ?g/kg b.w., i.v.), a dopamine receptor antagonist and to domperidone plus formalin stress was tested in adrenalectomized and/or dexamethasone-treated continuously nursing rats. Animals were adrenalectomized on the 3rd day of lactation and tested on the 7th day of lactation. Dexamethasone was injected s.c. 24 h before testing (400 ?g/kg b.w.) and on the day of testing (200 ?g/kg b.w.). Domperidone caused a significant rise in plasma prolactin levels. The prolactin response to domperidone was twice as high in solely adrenalectomized dams and in solely dexamethasone-treated rats compared to controls. In adrenalectomized animals treated with dexamethasone, the prolactin response to domperidone was like in controls. Formalin injection to either adrenalectomized plus domperidone-treated animals or to animals injected with dexamethasone plus domperidone, resulted in a statistically significant depletion of plasma prolactin. In controls and in adrenalectomized animals receiving dexamethasone and domperidone, the prolactin response to formalin was very similar, i.e., plasma prolactin levels did not change after the administration of formalin. The present findings suggest that in lactating rats, corticosteroids are involved in the prolactin response to domperidone and to formalin stress.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Brain Research Bulletin 56 : 6 (2001), p. 589-592. -
További szerzők:Bánky Zsuzsanna Tóth E. Béla (1960-) (orvos) Halász Béla Nagy György M.
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

9.

001-es BibID:BIBFORM073602
Első szerző:Horváth Katalin M.
Cím:Inhibition of protein phosphatase 2A (PP2A) mimics suckling-induced sensitization of mammotropes : involvement of a pertussis toxin (PTX) sensitive G-protein and the adenylate cyclase (AC) / Katalin M. Horváth, Balázs Radnai, Tóth E. Béla, Márton I. K. Fekete, György M. Nagy
Dátum:1999
ISSN:0303-7207
Megjegyzések:In lactating rats, suckling renders mammotropes more responsive to prolactin (PRL)-releasing stimuli and less responsive to PRL-inhibiting secretagogues. We have previously shown that a decrease in the activity of protein phosphatase 2A (PP2A) may be responsible for the decrease in responsiveness to the inhibitory secretagogue dopamine (DA). In our present experiments, we have studied the involvement of the adenylate cyclase (AC), stimulatory and inhibitory GTP-binding proteins and also the role of PP2A in the sensitization phenomenon. Pituitary cells obtained from mother rats separated from their pups for 4 h prior to dispersion (non-suckled), suckled for 10 or 30 min after the separation period (suckled) and without separation (continual suckling) were incubated in the presence of different doses of forskolin to activate AC and DA. In a further study, pituitary cells of non-suckled rats were pretreated with cholera toxin (CTX) or pertussis toxin (PTX) and tested for the stimulatory action of forskolin or TRH on PRL release. Ocadaic acid (OA) pretreatment has been used to investigate the involvement of PP2A. Hormone secretion was measured by the reverse hemolytic plaque assay (RHPA). Our results have shown that cells from non-suckled rats were unresponsive to forskolin. A 10-min suckling stimulus sensitizes pituitary mammotropes to respond with a PRL release to a dose-dependent activation of AC by forskolin. This sensitization of AC becomes a permanent feature of the cells when suckling continues for an additional 20 min. We have also found that pituitary mammotropes from non-suckled dams respond to forskolin or TRH with PRL release when they were preincubated with either PTX or the PP2A inhibitor OA. It clearly indicates that the non-responsive pituitary can be shifted to the responsive stage by uncoupling of inhibitory G-protein from its receptor as well as by inhibition of PP2A. This latter finding, consonant with our previous results, suggests that suckling may cause selective changes in the function of Gi of mammotropes due to a rapid phosphorylation which can remove tonic, GTP-dependent inhibitory function.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Molecular And Cellular Endocrinology 149 : 1-2 (1999), p. 1-7. -
További szerzők:Radnai Balázs Tóth E. Béla (1960-) (orvos) Fekete I. K. Márton Nagy György M.
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

10.

001-es BibID:BIBFORM073594
Első szerző:Hubina Erika
Cím:Dexamethasone and adrenocorticotropin suppress prolactin secretion in humans / Erika Hubina, György M. Nagy, Béla E. Tóth, Gabriella Iván, Zoltán Görömbey, István Szabolcs, László Kovács, Miklós I. Góth
Dátum:2002
ISSN:0969-711X
Megjegyzések:It has been demonstrated that the regulatory pathways mediating basal and/or stimulus-induced prolactin (PRL) release in mammals are highly sensitive to adrenal corticoid inhibitory influence. We have investigated the effect of four different doses of dexamethasone (DEX) and the effect of adrenocorticotropin on PRL secretion in 197 patients (169 female, 28 male; age: 18?66 yr) with suspected hypercortisolemia?but only those with a normal glucocorticoid suppression test were involved in the study?and in 66 female patients (age: 18?39 yr) with suspected adrenocorticotropin-dependent hyper-androgenism. Overnight (1 mg), low-dose (0.5 mg every 6 h for 2 d), high-dose (2 mg every 6 h for 2 d), and long-lasting administration of DEX (0.5 mg every 6 h for 5 d) resulted in a significant decrease in PRL levels compared to the baseline. Similarly, a reduction in PRL levels could be detected following injection of adrenocorticotropin (250 ?g). In hyperprolactinemic patients, the DEX-induced increase in PRL (?PRL, expressed in percentage of baseline) was significantly larger compared with normoprolactinemic subjects in all groups except those who received high-dose DEX) or adrenocorticotropin. These data clearly indicate that the secretory function of PRL cells in humans is sensitive to changes in the activity of the hypothalamo-pituitary-adrenal axis in a dose-dependent manner.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Endocrine. - 18 : 3 (2002), p. 215-219. -
További szerzők:Nagy György M. Tóth E. Béla (1960-) (orvos) Iván Gabriella Görömbey Zoltán (1956-) (idegsebész) Szabolcs István Kovács László Góth Miklós
Pályázati támogatás:035216
OTKA
030748
OTKA
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

11.

001-es BibID:BIBFORM066180
035-os BibID:(cikkazonosító)GP121
Első szerző:Nagy György M.
Cím:Expression of dopamine (DA) D2 receptors (D2R) in corticotroph cells is responsible for the switch of hypothalamic regulation of ACTH secretion to DA in lactating rats / György M. Nagy, Pálma Fehér, Ibolya Bodnár, Reid Luke, Zsuzsanna E. Tóth, Miklós Vecsernyés, Béla E. Tóth
Dátum:2016
ISSN:1470-3947 1479-6848
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok poszter
folyóiratcikk
Megjelenés:Endocrine Abstracts. - 41 (2016), p. 1. -
További szerzők:Fehér Pálma (1976-) (gyógyszerész) Bodnár Ibolya Luke, Reid Tóth Zsuzsanna (1977-) (kardiológus) Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Tóth E. Béla (1960-) (orvos)
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

12.

001-es BibID:BIBFORM073665
Első szerző:Oláh Márk
Cím:Role of salsolinol in the regulation of pituitary prolactin and peripheral dopamine release / Márk Oláh, Ibolya Bodnár, Galit Daniel, Béla E. Tóth, Miklós Vecsernyés, György M. Nagy
Dátum:2011
ISSN:1445-5781 1447-0578
Megjegyzések:(R)?Salsolinol (SAL), a dopamine (DA)?related tetrahydroisoquinoline, has been found in extracts of the neuro?intermediate lobes (NIL) of pituitary glands and in the median eminence of the hypothalamus obtained from intact male rats and from ovariectomized and lactating female rats. Moreover, analysis of SAL concentrations in NIL revealed parallel increases with plasma prolactin (PRL) in lactating rats exposed to a brief (10 min) suckling stimulus after 4?h separation. SAL is sufficiently potent in vivo to account for the massive discharge of PRL that occurs after physiological stimuli (i.e. suckling). At the same time, it was without effect on the secretion of other pituitary hormones. It has been also shown that another isoquinoline derivative, 1?methyldihydroisoquinoline (1MeDIQ), which is a structural analogue of SAL, can dose?dependently inhibit the in?vivo PRL?releasing effect of SAL. Moreover, 1MeDIQ can inhibit the elevation of plasma PRL induced by physiological stimuli, for example suckling, or in different stressful situations also. 1MeDIQ also has a psycho?stimulant action, which is fairly similar to the effect of amphetamine, i.e. it induces an increase in plasma catecholamine concentrations. It is clear from these data that this newly discovered endogenous compound could be involved in regulation of pituitary PRL secretion. It has also been observed that SAL is present in peripheral, sympathetically innervated organs, for example the atrium, spleen, liver, ovaries, vas deferens, and salivary gland. Furthermore, SAL treatment of rats results in dose?dependent and time?dependent depletion of the DA content of the organs listed above without having any effect on the concentration of norepinephrine. More importantly, this effect of SAL can be completely prevented by amphetamine and by 1MeDIQ pretreatment. It is clear there is a mutual interaction between SAL, 1MeDIQ, and amphetamine or alcohol, not only on PRL release; their interaction with catecholamine "synthesis/metabolism" of sympathetic nerve terminals is also obvious.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Reproductive Medicine and Biology 10 : 3 (2011), p. 143-151. -
További szerzők:Bodnár Ibolya Daniel, Galit Tóth E. Béla (1960-) (orvos) Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Nagy György M.
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1 2 
Corvina könyvtári katalógus v8.2.27 © 2023 Monguz kft. Minden jog fenntartva.