CCL

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1.

001-es BibID:BIBFORM073584
Első szerző:Ács Zsuzsanna
Cím:Rat milk stimulates pituitary growth hormone secretion of neonatal pituitaries in vitro / Ács Zs., Kacsóh B., Veress Z., Tóth B. E.
Dátum:1988
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Life sciences 42 : 23 (1988), p. 2315-2321. -
További szerzők:Kacsóh Bálint Veress Zoltán Tóth E. Béla (1960-) (orvos)
Borító:

2.

001-es BibID:BIBFORM073546
Első szerző:Kacsóh Bálint
Cím:Neuroendocrine control of immunoreactive growth hormone and bioactive prolactin secretion in neonatal rats : ontogeny and interactions between the serotonergic, cholinergic and alpha 2-adrenergic systems / Kacsóh B., Tóth B. E., Grosvenor C. E.
Dátum:1993
ISSN:0028-3835
Megjegyzések:The effects of the alpha 2-agonist clonidine (CLO), the serotonin (5-HT) precursor 5-hydroxy-L-tryptophan (5-HTP), the 5-HT2/histamine (H1) antagonist cyproheptadine (CYPRO), the muscarinic cholinergic antagonist atropine (ATR), and an affinity-purified polyclonal anti-rat growth hormone-releasing hormone (rGHRH) immunoglobulin on serum concentrations of growth hormone (GH) and prolactin (PRL) were tested in 2- and 10-day-old litter-mate rat pups. Serum levels of GH and PRL were detected in RIA and Nb2 lymphoma bioassay, respectively. The effects of two different drugs either alone or in combination with each other were evaluated by two-factor analysis of variance. The data indicated that secretion of GH and PRL was regulated by alpha 2-adrenergic, serotonergic and cholinergic mechanisms; the pathways regulating the two hormones, however, were distinct. 5-HTP stimulated GH secretion as early as day 2 postpartum via cholinergic mechanisms not involving GHRH; this pathway was also present in 10-day-old pups. An additional serotonergic pathway was functional in 10-day-old pups which mediated CLO-induced release of GH, and did not include cholinergic transmission.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Prolactin Prolactin-releasing factors Development
Megjelenés:Neuroendocrinology 57 : 2 (1993), p. 195-203. -
További szerzők:Tóth E. Béla (1960-) (orvos) Grosvenor, Clark E.
Internet cím:DOI
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3.

001-es BibID:BIBFORM073570
Első szerző:Kacsóh Bálint
Cím:In vitro control of prolactin (PRL) and growth hormone secretion of neonatal rat pituitary glands : effects of ovine PRL, salmon calcitonin, endothelin-3, angiotensin II, bromocryptine and somatostatin / Kacsóh B., Tóth B. E., Avery L. M., Grosvenor C. E.
Dátum:1993
Megjegyzések:Bromocryptine potently decreased prolactin (PRL) secretion of pituitary glands of 2-day-old rats in vitro (up to 85% inhibition; ED50 between 0.1 and 1.0 nM) without altering the bioactivity to immunoreactivity (B/I) ratio. Bromocryptine tended to suppress growth hormone (GH) secretion although the effect did not reach statistical significance. Angiotensin-II (A-II; 1-1000 nM) stimulated PRL secretion in a dose-dependent manner without affecting secretion of GH. The B/I ratio of PRL secreted in response to A-II was increased. Somatostatin (SRIF) had no effect on PRL secretion but inhibited GH secretion in a dose-dependent manner; significant inhibition (50%) was observed at 100 nM. A 6-h exposure to ovine PRL (oPRL) in concentrations equipotent with 1.2-120 ng/ml rat PRL (rPRL) in the Nb2 bioassay had no effect on immunoreactive rPRL secretion. Salmon calcitonin (sCT) and endothelin-3 (ET-3; 0.1-100 nM) failed to inhibit secretion of PRL or GH. PRL secretion was slightly stimulated by sCT with no apparent dose-response relationship. The present findings suggest that neonatal pituitary glands do not display autoregulation of PRL secretion, and sCT and ET-3 (either endogenous or milk-derived) may not function as PRL inhibiting factors in 2-day-old pups. Thus, the receptors of PRL, sCT and ET-3 on lactotropes, or their functional coupling with inhibition of basal PRL secretion, occur at a later stage of development. The specificity of the PRL releasing factor (PRF) activity of A-II at this age is unique for established PRFs and might reflect a physiological function of PRL in osmoregulation. The increased B/I ratio of PRL secreted in response to A-II may be due to the release of specific PRL variants, and might be a sign of functional heterogeneity among lactotropes. The differential sensitivity of PRL and GH to the applied secretagogues suggests that the intracellular regulation of PRL and GH are compartmentalized in the mammosomatotrope cell.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Life Sciences 57 : 2 (1993), p. 195-203. -
További szerzők:Tóth E. Béla (1960-) (orvos) Avery, Leann M. Grosvenor, Clark E.
Borító:

4.

001-es BibID:BIBFORM073571
Első szerző:Kacsóh Bálint
Cím:Bioactive and immunoreactive variants of prolactin in milk and serum of lactating rats and their pups / Kacsóh B., Veress Z., Tóth B. E., Avery L. M., Grosvenor C. E.
Dátum:1993
Megjegyzések:Prolactin (PRL)-like bioactivity (in Nb2 lymphoma assay) and immunoreactivity (in radioimmunoassay (RIA)) in rat milk, maternal and neonatal sera and in neonatal rat pituitary cultures were investigated. The PRL-like bioactivity in the water-soluble fraction of rat milk was high and exceeded its immunoreactivity 5.8-, 4.0- and 2.1-fold, on days 2, 12 and 22 of lactation respectively. The elevated bioactivity to immunoreactivity (B/I) ratio of PRL in milk was not due to the presence of interleukin-2 (IL-2) in milk, since the proliferation of the CTLL-2 murine T cells, which are not sensitive to PRL, was promoted by IL-2 but not by milk. Serum levels of immunoreactive PRL were low in sera of non-weaned rat pups on days 2, 12 and 22 postpartum. Similar to milk, the B/I ratio of PRL in sera of rat pups was high and decreased with time postpartum. Pituitary glands of pups obtained on days 2, 12 and 22 secreted progressively increasing amounts of PRL in vitro; the B/I ratio ranged between 1.2 and 2.1 without a significant change. The relative concentrations of size variants in milk were not proportional to those in serum of lactating rats on day 2 postpartum as assessed by Sepharcryl S-100 HR gel permeation chromatography and Nb2 bioassay or RIA. Size variants of biologically active PRL were abundant in early milk and gradually diminished as lactation progressed: a partially resolved peak representing monomeric to dimeric PRL variants (relative molecular weights ranging between 18 k and 42 k) became progressively narrower between days 2 and 22. Biologically active and immunoreactive PRLs displayed disparate elution profiles. The elution profile of PRL in sera of neonatal rats on day 2 post-partum was different from that of maternal serum or milk. The major immunological (and possibly biological) PRL-like activity eluted as two adjacent peaks at 2.2 k and 1.5 k, raising the possibility that fragments of milk-borne PRL were absorbed from the gut after partial proteolytic degradation. In contrast with PRL, GH (which is present in rat milk only in minute concentrations) did not show heterogeneity in sera of 2-day-old rat pups in gel permeation chromatography. The present results demonstrate that the concentrations of PRL-like activity in rat milk and newborn rat serum have been grossly underestimated because levels have been measured by RIA. The high B/I ratio of PRL in milk and neonatal sera is due to the presence of PRL-related compounds.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Endocrinology 138 : 2 (1993), p. 243-257. -
További szerzők:Veress Zoltán Tóth E. Béla (1960-) (orvos) Avery, Leann M. Grosvenor, Clark E.
Borító:

5.

001-es BibID:BIBFORM073576
Első szerző:Kacsóh Bálint
Cím:Thyrotropin-releasing hormone mediates growth hormone release induced by milk and nursing in neonatal rats / Kacsóh B., Tóth B. E., Grosvenor C. E.
Dátum:1992
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Neuroendocrinology 4 : 6 (1992), p. 663-672. -
További szerzők:Tóth E. Béla (1960-) (orvos) Grosvenor, Clark E.
Borító:

6.

001-es BibID:BIBFORM073578
Első szerző:Kacsóh Bálint
Cím:Molecular heterogeneity of prolactin in lactating rats and their pups : biological and immunological activities in pituitary gland, serum and milk / Kacsóh B., Tóth B. E., Avery L. M., Yamamuro Y., Grosvenor C. E.
Dátum:1991
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Endocrine regulations 25 : 1-2 (1991), p. 98-110. -
További szerzők:Tóth E. Béla (1960-) (orvos) Avery, Leann M. Yamamuro, Yutaka Grosvenor, Clark E.
Borító:

7.

001-es BibID:BIBFORM073585
Első szerző:Kacsóh Bálint
Cím:Data suggesting that milk of early lactation period might be involved in sexual differentiation of rat brain / Kacsoh B., Nagy G., Veress Z., Toth B. E., Kanyicska B., Csernus V., Koves K.
Dátum:1986
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Endocrinologia experimentalis 20 : 2-3 (1986), p. 155-166. -
További szerzők:Nagy G. Veress Zoltán Tóth E. Béla (1960-) (orvos) Kanyicska Béla (tudományos segédmunkatárs) Csernus Valér J. Köves Katalin
Borító:

8.

001-es BibID:BIBFORM069282
Első szerző:Kurtz, Andreas
Cím:Mammary Epithelial Cells of Lactating Rats Express Prolactin Messenger Ribonucleic Acid / Andreas Kurtz, Lynn A. Bristol, Béla E. Tóth, Eliane Lazar-Wesley, László Takács, Bálint Kacsóh
Dátum:1993
ISSN:0006-3363
Megjegyzések:The presence of prolactin (PRL) mRNA in the mammary gland, placenta, and pituitary gland of lactating and pregnant ratswas investigated by polymerase chain reaction (PCR). Polyadenylated RNA was prepared from total RNA samples by oligo(dT)-cellulose chromatography, and complementary cDNAs were synthesized. A standardized amount of cDNA from each sample wasused as the template in a Taq PCR under high-stringency conditions. PCR amplified a signal with the predicted size of approximately375 bp in mammary and pituitary glands of lactating and pregnant rats, and in placentae of pregnant rats. This bandspecifically hybridized with a probe overlapping the entire sequence of the mature rat (r) PRL mRNA in Southern blot analysis.When the rPRL-specific primers were used, PCR revealed no signal in the liver or in lactating mammary gland explants culturedin vitro for 48 h, while the same cDNA preparations gave strong signals for R-actin. The viability of the mammary gland explantswas also suggested by their ability to secrete immunoreactive casein in vitro. PRL mRNA was localized in the epithelium of alveoliand ducts of the lactating mammary gland by in situ hybridization. These data provide evidence that the PRL gene is expressedin the mammary gland of pregnant and lactating rats, and suggest that the mammary gland might contribute to PRL in milk byde novo synthesis. Thus, while the placenta is an exogenous source of PRL-like activities for the fetus in utero, the mammarygland might take over this function after birth.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Biology of Reproduction 48 : 5 (1993), p. 1095-1103. -
További szerzők:Bristol, Lynn A. Tóth E. Béla (1960-) (orvos) Lazar-Wesley, Eliane Takács László (1955-) Kacsóh Bálint
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
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9.

001-es BibID:BIBFORM073586
Első szerző:Nagy G. (Budapest)
Cím:Separation and suckling-induced changes in serum growth hormone levels of lactating rats and their pups / Nagy G., Kacsoh B., Kanyicska B., Toth B. E., Korausz E.
Dátum:1986
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Endocrinologia experimentalis 20 : 2-3 (1986), p. 217-222. -
További szerzők:Kacsóh Bálint Kanyicska Béla (tudományos segédmunkatárs) Tóth E. Béla (1960-) (orvos) Korausz E.
Borító:

10.

001-es BibID:BIBFORM073650
Első szerző:Tóth E. Béla (orvos)
Cím:Antimitogenic Activity in Rat Milk : effects of Prolactin Induced Mitogenesis of Nb2 rat Lymphoma Cells in vitro / Béla E. Tóth, Yutaka Yamamuro, Bálint Kacsóh, Clark E. Grosvenor, Leann M. Avery
Dátum:1992
ISBN:0471561347
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok könyvfejezet
Megjelenés:Mechanisms Regulating Lactation and Infant Nutrient Utilization / eds. Mary Frances Picciano, Bo Lönnerdal. - p. 443-450. -
További szerzők:Yamamuro, Yutaka Kacsóh Bálint Grosvenor, Clark E. Avery, Leann M.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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11.

001-es BibID:BIBFORM073581
Első szerző:Tóth E. Béla (orvos)
Cím:Rat milk inhibits the mitogenic response of Nb2 lymphoma cells to prolactin / Tóth B. E., Kacsóh B., Yamamuro Y., Avery L. M., Grosvenor C. E.
Dátum:1991
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Endocrine regulations 25 : 1-2 (1991), p. 120-127. -
További szerzők:Kacsóh Bálint Yamamuro, Yutaka Avery, Leann M. Grosvenor, Clark E.
Borító:

12.

001-es BibID:BIBFORM073583
Első szerző:Tóth E. Béla (orvos)
Cím:Prolactin-antagonist in rat milk / Toth B. E., Kacsoh B., Grosvenor C. E.
Dátum:1990
ISBN:0471561347
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok előadáskivonat
Megjelenés:Conference on Mechanisms Regulating Lactation and Infant Nutrient Utilization / eds. Toth B. E., Kacsoh B., Grosvenor C. E. - p. 461. -
További szerzők:Kacsóh Bálint Grosvenor, Clark E.
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