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001-es BibID:	BIBFORM073543
Első szerző:	Wenger Tibor
Cím:	Effects of anandamide (endogen cannabinoid) on anterior pituitary hormone secretion in adult ovariectomized rats / Wenger T., Tóth B. E., Martin B. R.
Dátum:	1995
ISSN:	0024-3205
Megjegyzések:	It has been shown that the main psychoactive component of marihuana, delta 9-tetrahydrocannabinol (THC) has mainly inhibitory effects on pituitary luteinizing hormone (LH), prolactin (PRL) and growth hormone (GH) and has no or little effect on follicle stimulating hormone (FSH) secretion. Recently the purification and availability of the putative endogenous ligand for the cannabinoid receptor, anandamide (arachidonyl ethanol-amide, anandamide) (ANA) provided us the opportunity to compare the effects of THC and ANA on the female neuroendocrine system in ovariectomized (OVX) rats. OVX was performed three weeks prior to the experimental period to avoid cyclic differences. OVX rats were injected i.p. with either THC or ANA (0.02 mg/kg.b.w./day, respectively) or vehicle for two weeks. The results show that both ANA and THC decrease serum LH level although THC with a higher degree. No significant differences were observed in serum FSH level. Both drugs decreased serum PRL. Serum GH was increased after THC administration and significantly decreased after ANA. The results indicate that ANA and THC alter pituitary hormone secretion, mainly by inhibitory action. The site of action requires further investigations.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban Prolactin Prolactin-releasing factors Development
Megjelenés:	Life Sciences 56 : 23-24 (1995), p. 2057-2063. -
További szerzők:	Tóth E. Béla (1960-) (orvos) Martin, Billy R.
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001-es BibID:	BIBFORM073603
Első szerző:	Wenger Tibor
Cím:	The effects of cannabinoids on the regulation of reproduction / Tibor Wenger, Béla E. Tóth, Christian Juanéda, Jean Leonardelli, Gérard Tramu
Dátum:	1999
ISSN:	0024-3205
Megjegyzések:	It has been shown that the main psychoactive component of marihuana, ?9tetrahydrocannabinol (THC) has mainly inhibitory effects on the regulation of reproduction. Recently, the purification and availability of the endogenous ligand of the cannabinoid receptor, arachidonyl ethanolamide, anandamide, (ANA) and its specific long lasting antagonist, the SR 141716 (SR) provided us the opportunity to compare the effects of THC and ANA on the neuroendocrine regulation of reproduction. ANA decreases serum luteinizing hormone (LH) and prolactin (PRL) levels in rats of both sexes. It has no action on serum follicle stimulating hormone (FSH) level. When ANA was administered to pregnant rats it resulted in an increase of the duration of pregnancy and in the frequency of stillbirths. The postnatal development of hypothalamo-pituitary axis in offspring was temporarily inhibited. In conclusion, we found that exogenous and endogenous cannabinoids have only slightly different effects on the reproductive parameters. These effects may occur via the central cannabinoid receptor. It is possible that the sites of action are at both hypothalamic and pituitary levels. The results further support the view that ANA may be a central neurotransmitter or neuromodulator.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Life Sciences 65 : 6-7 (1999), p. 695-701. -
További szerzők:	Tóth E. Béla (1960-) (orvos) Juanéda, Christian Leonardelli, Jean Tramu, Gérard
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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