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001-es BibID:BIBFORM073590
Első szerző:Góth Miklós
Cím:Physiological and pathological angiogenesis in the endocrine system / Miklós I. Góth, Erika Hubina, Stefanos Raptis, György M. Nagy, Béla E. Tóth
Dátum:2003
ISSN:1059-910X
Megjegyzések:Formation of new blood vessels occurs in many physiological states (during development of the embryo, cycling changes of the female reproductive tract), as well as in pathological processes (such as diabetic retinopathy and wound healing). Angiogenesis has been shown to be related to tumor formation, prognosis, and response to treatment in many tumor types. Intratumoral microvessels can be related to tumor behavior or hormone secretion in different endocrine tumors. For example, invasive prolactinomas are more vascular than noninvasive adenomas; a surgical approach is more successful in macroprolactinomas with lower microvessel density. A higher number of microvessels have been found in papillary thyroid carcinomas during recurrences. A correlation between microvessel count and prognosis in papillary and medullary thyroid carcinomas has been suggested. Several stimulating and inhibiting factors involved in the regulation of angiogenesis have been identified. Among them, vascular endothelial growth factor (VEGF) has been shown to be critically involved in angiogenesis and also in the neovascularization of solid tumors. Dopamine agonists (already in clinical use for prolactinomas) have potent inhibitory actions on VEGF signaling, and thus may be a new tool in antiangiogenic therapy. Secretion of VEGF in the great majority of human pituitary adenomas is inhibited by dexamethasone. This suggests that glucocorticoids can be considered in the treatment of certain pituitary tumors. The cyclic nature of angiogenesis in the female reproductive tract indicates that stimulation or inhibition of paracrine angiogenic factors may lead to new approaches for being able to influence reproductive endocrine disorders. Experimental and clinical aspects of interactions between angiogenic factors and tumor growth of the endocrine system are also discussed. Microsc. Res. Tech. 60:98?106, 2003. ? 2002 Wiley?Liss, Inc.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Microscopy Research and Technique 60 : 1 (2003), p. 98-106. -
További szerzők:Hubina Erika Raptis, Stefanos Nagy György M. Tóth E. Béla (1960-) (orvos)
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001-es BibID:BIBFORM073594
Első szerző:Hubina Erika
Cím:Dexamethasone and adrenocorticotropin suppress prolactin secretion in humans / Erika Hubina, György M. Nagy, Béla E. Tóth, Gabriella Iván, Zoltán Görömbey, István Szabolcs, László Kovács, Miklós I. Góth
Dátum:2002
ISSN:0969-711X
Megjegyzések:It has been demonstrated that the regulatory pathways mediating basal and/or stimulus-induced prolactin (PRL) release in mammals are highly sensitive to adrenal corticoid inhibitory influence. We have investigated the effect of four different doses of dexamethasone (DEX) and the effect of adrenocorticotropin on PRL secretion in 197 patients (169 female, 28 male; age: 18?66 yr) with suspected hypercortisolemia?but only those with a normal glucocorticoid suppression test were involved in the study?and in 66 female patients (age: 18?39 yr) with suspected adrenocorticotropin-dependent hyper-androgenism. Overnight (1 mg), low-dose (0.5 mg every 6 h for 2 d), high-dose (2 mg every 6 h for 2 d), and long-lasting administration of DEX (0.5 mg every 6 h for 5 d) resulted in a significant decrease in PRL levels compared to the baseline. Similarly, a reduction in PRL levels could be detected following injection of adrenocorticotropin (250 ?g). In hyperprolactinemic patients, the DEX-induced increase in PRL (?PRL, expressed in percentage of baseline) was significantly larger compared with normoprolactinemic subjects in all groups except those who received high-dose DEX) or adrenocorticotropin. These data clearly indicate that the secretory function of PRL cells in humans is sensitive to changes in the activity of the hypothalamo-pituitary-adrenal axis in a dose-dependent manner.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Endocrine. - 18 : 3 (2002), p. 215-219. -
További szerzők:Nagy György M. Tóth E. Béla (1960-) (orvos) Iván Gabriella Görömbey Zoltán (1956-) (idegsebész) Szabolcs István Kovács László Góth Miklós
Pályázati támogatás:035216
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030748
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DOI
Intézményi repozitóriumban (DEA) tárolt változat
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