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001-es BibID:	BIBFORM117874
035-os BibID:	(cikkazonosító)448 (Scopus)85183407744
Első szerző:	Tar Ildikó (fogszakorvos)
Cím:	Six-Month Follow-Up of Periodontal Condition in Rheumatoid Arthritis and Ankylosing Spondylitis Arthritis Patients Undergoing Anti-Tumour Necrosis Factor-alpha Therapy / Ildikó Tar, Edit Végh, Renáta Martos, Boglárka Soós, Ildikó Márton, Zoltán Szekanecz
Dátum:	2024
ISSN:	2077-0383
Megjegyzések:	In our present study, we aimed to assess the effects of anti-TNF therapy on periodontal condition in a mixed cohort of patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Moreover, we wished to determine whether the baseline dental condition of these patients would affect response to biological therapy. A cohort of 24 arthritis patients was consecutively recruited before starting anti-TNF? therapy. After the dropout of six patients, we evaluated the dental status of 18 subjects at baseline and after 6 months of biological therapy. Clinical responder (R) and non-responder (NR) status was determined after 6 months of anti-TNF treatment. Plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing pocket depth (PPD), PPDmax, clinical attachment loss (CAL), and CALmax were determined. During the 6-month treatment period, six patients (3 RA and 3 AS) terminated the study prematurely as they did not respond to treatment (NR). Therefore, 18 patients were included in the full analysis. There were no major differences in PI, BOP, PPD, PPD max, CAL, and CALmax, among R and NR patients. TNF inhibition resulted in increased GI (0.65 ? 0.34 vs. 0.88 ? 0.30; p < 0.05), as well as decreased PPDmax (4 ? 1.94 vs. 2.72 ? 1.36; p < 0.05) and CALmax (5.22 ? 2.56 vs. 2.72 ? 1.36; p < 0.05) after 6 months. Eight patients had incomplete canal fillings or dead pulps and/or apical periodontitis; six in the R and two in the NR group. In our present study, anti-TNF therapy seemed to worsen the extent of gingival inflammation (GI); however our results also do not support the reduction of mean CPD and CAL as reported by others
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk rheumatoid arthritis ankylosing spondylitis periodontitis anti-TNF treatment
Megjelenés:	Journal of Clinical Medicine. - 13 : 2 (2024), p. 1-10. -
További szerzők:	Végh Edit (1978-) (reumatológus, belgyógyász) Martos Renáta (1975-) (fogszakorvos) Soós Boglárka (1988-) (általános orvos) Márton Ildikó (1954-) (fogszakorvos) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM095570
035-os BibID:	(Cikkazonosító)13525 (WOS)000671783200023 (Scopus)85109034025
Első szerző:	Tar Ildikó (fogszakorvos)
Cím:	Salivary citrullinated proteins in rheumatoid arthritis and associated periodontal disease / Ildikó Tar, Éva Csősz, Edit Végh, Karin Lundberg, Nastya Kharlamova, Boglárka Soós, Zoltán Szekanecz, Ildikó Márton
Dátum:	2021
ISSN:	2045-2322
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Scientific Reports. - 11 : 1 (2021), p. 1-8. -
További szerzők:	Csősz Éva (1977-) (biokémikus, molekuláris biológus) Végh Edit (1978-) (reumatológus, belgyógyász) Lundberg, Karin Kharlamova, Nastya Soós Boglárka (1988-) (általános orvos) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Márton Ildikó (1954-) (fogszakorvos)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM071300
035-os BibID:	(WOS)000401523101101
Első szerző:	Tar Ildikó (fogszakorvos)
Cím:	Rheumatoid Arthritis and Periodontal Disease : association between Salivary Citrulline, ACPA Levels and Clinical Presentation / Tar I., Csösz É., Veiszenbacher É., Végh E., Bágyi K., Lundberg K., Kharlamova N., Márton I., Szekanecz Z.
Dátum:	2016
ISSN:	0003-4967
Megjegyzések:	AbstractBackground Periodontitis and other dental conditions have been associated with the pathogenesis of rheumatoid arthritis (RA). In addition, these dental pathologies are also important comorbidities for RA.Objectives We wished to evaluate the periodontal involvement of rheumatoid arthritis (RA) patients, and we correlated with various laboratory biomarkers including lipids, autoantibodies, serum vitamin D levels, markers of bone metabolism in relation with the periodontal condition and cariological indices; and also correlated them with salivary citrulline and anti citrullinated protein autoantibody levels with the above mentioned clinical and blood test findings.Methods Twenty-three RA patients were recruited for the study. Saliva samples were taken following whole scale periodontal and cariological examination. Protein concentration, peptidyl-citrulline and anti-cyclic citrullinated protein (anti-CCP) levels were measured from saliva samples. Blood test results were provided by rheumatologists. Citrullinated enolase protein-1 (CEP-1) level from serum was also measured.Results Periodontal diagnoses (scores) seem to have a positive dependency on LDL (R=0.722, p=0.008), PTH1 (R=0.586, p=0.022), D3 vitamin level (R=0.586, 0.022), the sum of D3/D2 (R=0.634, p=0.011) respectively, in these patients. Anti-CEP-1 positive patients had significantly higher periodontal scores (2.71?0.11 vs 2.50?0.09, p<0.05) compared to anti-CEP-1 negative subjects. Interestingly, anti-CEP-1 positive patients had significantly higher triglyceride levels compared to seronegative ones (1.81?0.17 vs 1.42?0.05 mmol/l; p<0.05). Salivary citrulline and salivary anti-CCP, (p=0.007, R: 0.583) level has a correlation with the maximum of clinical probing depth.Conclusions Our results may add further pieces to the mosaic of RA-periodontitis connection. The possible role of antimicrobial immunity, as well as the possible role of lipids and bone metabolism have also been delineated. Future therapies should aim the disruption of this framework.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt folyóiratcikk rheumatoid arthritis periodontitis citrullin
Megjelenés:	Annals Of The Rheumatic Diseases. - 75 : Suppl 2 (2016), p. 1360. -
További szerzők:	Csősz Éva (1977-) (biokémikus, molekuláris biológus) Veiszenbacher Éva Végh Edit (1978-) (reumatológus, belgyógyász) Bágyi Kinga (1971-) (fogszakorvos) Lundberg, Karin Kharlamova, Nastya Márton Ildikó (1954-) (fogszakorvos) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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