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001-es BibID:	BIBFORM090993
Első szerző:	Tajti Gábor (gyógyszerész, biofizikus, sejtbiológus)
Cím:	The voltage-gated potassium channel KV1.3 as a therapeutic target for venom-derived peptides / Gábor Tajti, Dorothy C. C. Wai, György Panyi, Raymond S. Norton
Dátum:	2020
ISSN:	0006-2952
Megjegyzések:	The voltage-gated potassium channel KV1.3 is a well-established therapeutic target for a range of autoimmune diseases, in addition to being the site of action of many venom-derived peptides. Numerous studies have documented the efficacy of venom peptides that target KV1.3, in particular from sea anemones and scorpions, in animal models of autoimmune diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis. Moreover, an analogue of the sea anemone peptide ShK (known as dalazatide) has successfully completed Phase 1 clinical trials in mild-to-moderate plaque psoriasis. In this article we consider other potential therapeutic applications of inhibitors of KV1.3, including in inflammatory bowel disease and neuroinflammatory conditions such as Alzheimer's and Parkinson's diseases, as well as fibrotic diseases. We also summarise strategies for facilitating the entry of peptides to the central nervous system, given that this will be a pre-requisite for the treatment of most neuroinflammatory diseases. Venom-derived peptides that have been reported recently to target KV1.3 are also described. The increasing number of autoimmune and other conditions in which KV1.3 is upregulated and is therefore a potential therapeutic target, combined with the fact that many venom-derived peptides are potent inhibitors of KV1.3, suggests that venoms are likely to continue to serve as a rich source of new pharmacological tools and therapeutic leads targeting this channel.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Voltage-gated potassium channel Peptide Toxin Inflammatory bowel disease Neuroinflammation Fibrosis Therapeutic development
Megjelenés:	Biochemical Pharmacology. - 181 (2020), p. 114146-. -
További szerzők:	Wai, Dorothy C. C. Panyi György (1966-) (biofizikus) Norton, Raymond S.
Pályázati támogatás:	EFOP-3.6.2-16-2017-00006 EFOP GINOP-2.3.2-15-2016-00015 GINOP NKFIH OTKA K119417 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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