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1.

001-es BibID:BIBFORM104993
Első szerző:Boldogh Bence Zoltán (Orvos)
Cím:Hysteroscopic polypectomy in an outpatient setting / Bence Zoltán Boldogh, Luca Lukács, Márton György Lipták, Rudolf Lampé, Tünde Herman, Péter Török
Dátum:2022
Megjegyzések:Background Endometrial polyps are the most frequently observed benign lesions inside the uterine cavity. The incidence of them is reported about 20 % to 30 % in the female population. Endometrial polyps can be single or multiple, their size varies from a few millimetres to several centimetres. They can be totally asymptomatic or can cause abnormal uterine bleeding and/or infertility. They can be diagnosed by transvaginal ultrasonography, saline infusion ultrasonography, or by direct hysteroscopic visualization, but only the last can offer histological confirmation and proper treatment. Polyps can be removed by blind Dilatation and Curettage (D&C), or by hysteroscopy with direct visualization. Due to the miniaturization of the hysteroscopic devices, polypectomy can be made in an outpatient setting without general anaesthesia and hospitalization. The office-hysteroscopic removal of the polyp can be done with many operative techniques for example: with miniaturized instruments (grasping forceps, scissors), with mini-resectoscope, with tissue removal device (TRD), or with laser. Methods We retrospectively analysed the data of 125 patients, who underwent hysteroscopic polypectomy without general anaesthesia, in an outpatient office, between November 2016 to January 2022. Results The mean age was 41.46 ? 10.50 years, and the mean Body Mass Index (BMI) was 25.22 ? 5.87. The indications for performing office-hysteroscopy were the following: 79 (63.20%) abnormal sonographic findings, 27 (21.60%) infertility, and 19 (15.20%) abnormal uterine bleeding. Out of the 125 polypectomies, 74 (59.20%) were done with mechanical instruments (grasping forceps, scissors), 50 (40.00%) with mini-resectoscope, and 1 (0.80%) with laser. Conclusions Our data show that the toolkit of office-hysteroscopy is appropriate for the treatment of endometrial polyps furthermore, the polypectomy can be performed in an outpatient, cost-effective way without general anaesthesia and hospitalization.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:Facts, views & vision in ObGyn. - 14 : 3 (2022), p. P257. -
További szerzők:Lukács Luca (1995-) (hallgató) Lipták Márton György (1988-) (Orvos) Lampé Rudolf (1983-) (szülész-nőgyógyász) Herman Tünde (1979-) (orvos) Török Péter (1975-) (szülész-nőgyógyász)
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2.

001-es BibID:BIBFORM098012
Első szerző:Boldogh Bence Zoltán (Orvos)
Cím:Új diagnosztikus eljárások szerepe a meddőség kivizsgálásában / Boldogh Bence Zoltán, Herman Tünde, Lipták Márton, Lampé Rudolf, Gergely Péter Attila, Török Péter
Dátum:2021
ISSN:0025-021X
Tárgyszavak:Orvostudományok Klinikai orvostudományok magyar nyelvű folyóiratközlemény hazai lapban
folyóiratcikk
Megjelenés:Magyar Nőorvosok Lapja. - 84 : 4 (2021), p. 186-193. -
További szerzők:Herman Tünde (1979-) (orvos) Lipták Márton György (1988-) (Orvos) Lampé Rudolf (1983-) (szülész-nőgyógyász) Gergely Péter (1974-) (igazságügyi orvosszakértő) Török Péter (1975-) (szülész-nőgyógyász)
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3.

001-es BibID:BIBFORM106175
035-os BibID:(cikkazonosító)811 (WOS)000911130600001 (Scopus)85145909463
Első szerző:Gullo, Giuseppe
Cím:Fertility-Sparing Strategies for Early-Stage Endometrial Cancer : Stepping towards Precision Medicine Based on the Molecular Fingerprint / Gullo Giuseppe, Cucinella Gaspare, Chiantera Vito, Dellino Miriam, Cascardi Eliano, Török Péter, Herman Tünde, Garzon Simone, Uccella Stefano, Lagana Antonio Simone
Dátum:2023
ISSN:1422-0067
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:International Journal Of Molecular Sciences. - 24 : 1 (2023), p. 1-5. -
További szerzők:Cucinella, Gaspare Chiantera, Vito Dellino, Miriam Cascardi, Eliano Török Péter (1975-) (szülész-nőgyógyász) Herman Tünde (1979-) (orvos) Garzon, Simone Uccella, Stefano Laganà, Antonio Simone
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4.

001-es BibID:BIBFORM117861
Első szerző:Herman Tünde (orvos)
Cím:Hashimoto's thyroiditis negatively influences ICSI outcome in euthyroid women on T4 substitution therapy; a retrospective study / Tünde Herman, Péter Török, Antonio Simone Laganà, Vito Chiantera, Renato Venezia, Attila Jakab
Dátum:2024
ISSN:0378-7346
Megjegyzések:Abstract Objective: To analyze the impact of thyroid autoimmunity (TAI) on reproductive outcome parameters of ICSI cycles as compared to TAI negative ICSI cycles. Design: In this single IVF center retrospective study 86 infertile women with elevated TPOAb or TGAb levels, but euthyroid after thyroxine replacement (study group), were compared to 69 female patients with no thyroid abnormalities (controls). Following ICSI treatment fertilization rate (FR), clinical pregnancy rate (CPR), miscarriage rate (MR) and live birth rate (LBR) were analyzed. Materials, Setting, Methods: All subjects with various infertility factors were treated with ICSI in university based IVF center. Patients in the study group received thryroxine replacement and were euthyreoid at IVF treatment. Before the IVF cycles endocrinological parameters were uniformly assessed: thyroid function and antibodies, reproductive hormones (AMH, FSH, LH, E2, PRL, testosterone, DHEAS, 17-OHP, AD) and OGTT (0-60-120 min glucose and insulin). Following descriptive comparison of laboratory parameters, age adjusted analyses of FR, CPR, MR and LBR were performed. Results: TAI positive women were older (mean age 35.31?4.95 vs. 32.15?4.87 years; p=0.002), had higher FSH (8.4?3.4 vs. 7.4?2.32 U/L; p=0.024), higher E2 (53.94?47.61 vs. 42.93?18.92 pg/ml; p=0.025) levels, while AMH (2.88?2.62 vs. 3.61?1.69 ng/ml; p=0.0002) was lower. There were no differences in TSH levels (1.64?0.96 vs. 1.66?0.65 uIU/ml; p=0.652) between the two groups. FT3 (2.63?0.58 vs. 2.98?0.55 pg/ml; p=0.002) was lower and FT4 (1.3?0.29 vs. 1.13?0.21 ng/dl; p=0.0002) was higher in the TAI positive group, reflecting clinically irrevelant differences. Egg cell counts (6?3.8 vs. 7.5?3.95; p=0.015) were lower in TAI and remained so following age adjustment. Although the overall ICSI FR did not differ (62.9 % vs. 69.1 %, p=0.12), it was lower for patients under 35 with TAI showing decreasing differences in line with age. The CPR (36.04 % vs. 69.56 %; p<0.001), LBR (23.25 % vs. 60.86 %; p<0.001) were lower, the MR (35.48 % vs. 12.5 %; p=0.024) was higher in the TAI group and these differences remained after age adjustment. Limitations: Since the higher age of the study group may interfere with the effect of TAI, age adjustment calculations were necessary to perform to eliminate this confounding factor. Conclusion: Despite optimal thyroid supplementation in clinical or subclinical hypothyreoidism, the presence of TAI negatively influences clinical pregnancy rate and is connected to a higher miscarriage rate, thus resulting in a lower live birth rate after ICSI. Decreased fertilization rate with ICSI in TAI patients may also contribute to poorer outcomes, especially in younger women.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
IVF
ICSI
Hashimoto thyreoiditis
Megjelenés:Gynecologic And Obstetric Investigation. - [Epub ahead of print] (2024). -
További szerzők:Török Péter (1975-) (szülész-nőgyógyász) Laganà, Antonio Simone Chiantera, Vito Venezia, Renato Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus)
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5.

001-es BibID:BIBFORM105360
035-os BibID:(WoS)000894986300001 (Scopus)85143521697
Első szerző:Herman Tünde (orvos)
Cím:Impact of endocrine disorders on IVF outcomes : results from a large, single-centre, prospective study / T. Herman, Sz. Csehely, M. Orosz, H. P. Bhattoa, T. Deli, P. Török, A. S. Laganà, V. Chiantera, A. Jakab
Dátum:2023
ISSN:2045-2322
Megjegyzések:Endocrine disorders negatively influence the ovarian function and increasing incidence of endocrine diseases with age may have further negative effects on pregnancy rate. Prospective cohort study of 231 consecutively enrolled patients underwent IVF treatment. In patients with known endocrine disorders the laboratory parameters were corrected before IVF treatment. 161 patients (69.7%) had at least one known and treated endocrine disorder (study group), and 70 patients were endocrine negative (control group). Endocrine disorders diagnosed were thyroid disorders (32,5%), diminished ovarian reserve (23,8%), insulin resistance (22,5%), PCOS (15,2%), hyperprolactinemia (13,4%), obesity (12,1%), hypogonadotropic hypogonadism (0,8%), congenital adrenal hyperplasia (0.2%). Before the IVF treatment systematic endocrine laboratory examinations were performed in all patients. Higher age, BMI, and FSH was found in the study group, while AMH level was lower. There were no differences in LH, E2, prolactin, TSH, FT3, FT4, TT, DHEAS, androstendione, 17-OHP, SHBG level between the study and control groups. The study group had higher baseline glucose, baseline insulin, 120 minute glucose and 120 minute insulin level after oral glucose tolerance test. With no difference in the IVF cycles performed, pregnancy rate was lower in the study group (61.43 % vs. 34.16 %; p=0.003), and this difference (p=0.0151) remained in age-corrected rates, as well. The analysis were also performed in individual endocrinology groups. The prevalence of endocrine disorders is high in females participating in IVF programs and they often accompanying to each other. Even after proper correction, the presence of the endocrine disorder negatively influences the pregnancy rate in IVF treatment.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
assisted reproduction
in vitro fertilization
endocrine diseases
thyroid diseases
Megjelenés:Reproductive Sciences. - 30 : 6 (2023), p. 1878-1890. -
További szerzők:Csehely Szilvia (1990-) (szülész-nőgyógyász szakorvos) Orosz Mónika (1991-) (Szülész-nőgyógyász) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Deli Tamás Török Péter (1975-) (szülész-nőgyógyász) Laganà, Antonio Simone Chiantera, Vito Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus)
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6.

001-es BibID:BIBFORM101643
035-os BibID:(scopus)85129214860 (wos)000795847700003
Első szerző:Herman Tünde (orvos)
Cím:Endokrin kórképek előfordulása és társulása in vitro fertilizációs programban részt vevő nők körében / Herman Tunde, Csehely Szilvia, Orosz Monika, Bhattoa Harjit Pal, Deli Tamás, Török Péter, Jakab Attila
Dátum:2022
ISSN:0030-6002 1788-6120
Tárgyszavak:Orvostudományok Klinikai orvostudományok magyar nyelvű folyóiratközlemény hazai lapban
folyóiratcikk
Megjelenés:Orvosi Hetilap. - 163 : 18 (2022), p. 712-719. -
További szerzők:Csehely Szilvia (1990-) (szülész-nőgyógyász szakorvos) Orosz Mónika (1991-) (Szülész-nőgyógyász) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Deli Tamás (1979-) (szülész-nőgyógyász, endokrinológus szakorvos) Török Péter (1975-) (szülész-nőgyógyász) Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus)
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7.

001-es BibID:BIBFORM088442
Első szerző:Herman Tünde (orvos)
Cím:In Vitro Fertilization Treatment of a Patient with Primary Partial Empty Sella and Other Co-Factors / Tünde Herman, Péter Török, Antonio Simone Laganȧ, Attila Jakab
Dátum:2020
ISSN:2377-9004
Megjegyzések:We report the case of a patient with primary empty sella, who had successful assisted reproductive treatment. The patient is a 28-years-old infertile female with primary amenorrhoea and hypogonadotropic hypogonadism. Serum FSH, LH, E2 indicated central anovulation, but the production of GH, ACTH, TSH and PRL were normal. Obesity and insulin resistance were present. Male partner had asthenozoo-teratospermia and hyperprolactinaemia. After three failed intrauterine inseminations, she was addressed to gynecologic endocrinology where cerebral MRI was done, which revealed partial empty sella. Due to the combination of several infertility factors, the couple was referred for IVF. Since the initial fertilization rate was low at IVF-ICSI and implantation failed, intensive lifestyle modification and endocrinological care was introduced for 5 months, then the second IVF treatment was effective and, after a relatively uneventful pregnancy, healthy twin boys were born near-term.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Hypogonadotropic hypogonadism (HH)
Primary empty sella (PES)
Astheno-teratozoospermia (AT)
In vitro fertilization (IVF)
Megjelenés:Obstetrics and Gynaecology Cases - Reviews. - 7 : 5 (2020), p. 1-6. -
További szerzők:Török Péter (1975-) (szülész-nőgyógyász) Laganà, Antonio Simone Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus)
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8.

001-es BibID:BIBFORM104438
Első szerző:Lipták Márton György (Orvos)
Cím:Resection of fibroids in outpatient setting / Lipták Márton, Boldogh Bence, Lukács Luca, Herman Tünde, Lampé Rudolf, Török Péter
Dátum:2022
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:Facts, views & vision in ObGyn. - 14 : 3 (2022), p. P134. -
További szerzők:Boldogh Bence Zoltán (1995-) (Orvos) Lukács Luca (1995-) (hallgató) Herman Tünde (1979-) (orvos) Lampé Rudolf (1983-) (szülész-nőgyógyász) Török Péter (1975-) (szülész-nőgyógyász)
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9.

001-es BibID:BIBFORM097395
Első szerző:Lőrincz Judit (általános orvos)
Cím:Hystero-salpingo scintigraphy for fallopian tubal patency assessment : results from a prospective study / Lörincz Judit, Vitale Salvatore Giovanni, Barna Sándor Kristóf, Dinkó Fanni, Riemma Gaetano, Herman Tünde, Nagyházi Orsolya, Lampé Rudolf, De Franciscis Pasquale, Török Péter
Dátum:2022
ISSN:1364-5706
Megjegyzések:Objective: To evaluate the diagnostic accuracy of a bygone method, hystero-salpingo-scintig- raphy (HSSG), for tubal patency assessment of infertile women. Material and methods: Prospective cohort study involving women in the infertility workup at the University of Debrecen, Hungary. Seventy infertile patients were scheduled to either basic dynamic HSSG, post-purge dynamic HSSG, or post-purge dynamic HSSG followed by SPECT/CT for reducing tracer contamination. The primary endpoint was the evaluation of the diagnostic accuracy of HSSG for the three methods. Results: During the basic dynamic group, the examination yielded a sensitivity of 87.5%, with a specificity of 71.7%, while positive and negative predictive values were 31.8%, and 97.4% respectively. Using post purge dynamic HSSG, it resulted in a sensitivity of 87.5%, a specificity of 88.7%, a positive predictive value of 53.8%, and a negative predictive value of 97.9%. Adding SPECT/CT to post-purge dynamic HSSG increased diagnostic accuracy with 100% sensitivity and 88.7% specificity, while positive and negative predictive values were 57.1% and 100%, respectively. Conclusion: HSSG is a non-invasive and well-tolerated technique for tubal patency. It could be used initially to predict tubal patency in case of infertility. Its diagnostic accuracy is higher when it is carried out by adding SPECT/CT to the post-purge dynamic method.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
infertility
tubal patency
fallopian tube
scintigraphy
SPECT
radionuclides
Megjelenés:Minimally Invasive Therapy & Allied Technologies. - 31 : 5 (2022), p. 797-802. -
További szerzők:Vitale, Salvatore Giovanni Barna Sándor (1982-) (kutató orvos) Dinkó Fanni Riemma, Gaetano Herman Tünde (1979-) (orvos) Nagyházi Orsolya Lampé Rudolf (1983-) (szülész-nőgyógyász) De Franciscis, Pasquale Török Péter (1975-) (szülész-nőgyógyász)
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10.

001-es BibID:BIBFORM087601
Első szerző:Lőrincz Judit (általános orvos)
Cím:Predictive value of bubble sign for tubal patency during office hysteroscopy / Judit Lörincz, Szabolcs Molnár, Tünde Herman, Salvatore Giovanni Vitale, Singh Jashanjeet, Rudolf Lampé, László Kardos, Péter Török
Dátum:2020
ISSN:0301-2115
Megjegyzések:Objective: Our purpose was to investigate the predictive value of visible air bubble sign for real tubal patency during hysteroscopic procedures. Methods: In this cross-sectional study, clinical data of 61 infertile women who underwent diagnostic hysteroscopy and laparoscopy have been analysed. Results: Mean age of patients was 33.45 3.25 years. Bubble sign for the detection of patency demonstrated 73 % (95 % CI: 57?86 %) sensitivity, 70 % (95 % CI: 46?88 %) specificity, a positive predictive value of 83 % (95 % CI: 67?94 %), and a negative predictive value of 56 % (95 % CI: 35?76 %). Conclusions: A visible tubal "flow" of air bubbles during hysteroscopy was not accurate in the prediction of tubal patency.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Hysteroscopy
Bubble sign
Fallopian tubes
Tubal patency
Laparoscopy
Infertility
Megjelenés:European Journal of Obstetrics Gynecology and Reproductive Biology. - 253 (2020), p. 58-60. -
További szerzők:Molnár Szabolcs (1987-) (szülész-nőgyógyász szakorvos) Herman Tünde (1979-) (orvos) Vitale, Salvatore Giovanni Singh, Jashanjeet (1976-) (szülész-nőgyógyász szakorvos) Lampé Rudolf (1983-) (szülész-nőgyógyász) Kardos László (1970-) (megelőző orvostan és népegészségtan szakorvos) Török Péter (1975-) (szülész-nőgyógyász)
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11.

001-es BibID:BIBFORM078274
Első szerző:Lőrincz Judit (általános orvos)
Cím:The effect of localization and histological verification of endometrial polyps on infertility / Judit Lőrincz, Szabolcs Molnár, Attila Jakab, Tünde Herman, Singh Jashanjeet, Péter Török
Dátum:2019
ISSN:0932-0067 1432-0711
Megjegyzések:Aim Our purpose is to investigate if transcervical resection of endometrial polyps improves the fertility in ovulatory infertile women, and whether polyp histology, intrauterine location, and the technique of polypectomy have any influence on the pregnancy rates. Methods In this retrospective study, clinical data of 87 ovulatory infertile women who underwent hysteroscopy and pol- ypectomy, and their 12-month follow-up have been analyzed. Subgroups according to the method of polyp removal (resec- toscope or curettage), the polyp localization (utero-tubal, anterior, posterior, lateral, multiple) and the histological result were interpreted. Results Meanageofpatientswas33.99?4.24years.TherewerenodifferencesintheBMIandbasalFSHlevelsbetweenthe subgroups. Pregnancy was recorded in 30 (34.5%) within the next 12 months without any difference between the subgroups of polypectomy method applied. Posterior wall polyp resection increased the pregnancy chance (OR 5.02), but no other dif- ferences were observed in 1-year pregnancy rates to other localizations. Removal of polyps which had normal endometrial histology had lower pregnancy rates as compared to that of polyps with hyperplasia or endometrial polyp histology results (OR 0.25). Conclusions Polypectomy improved the conception rate in the subsequent year regardless of the intrauterine localization and the method of its surgical removal. Therefore, we can conclude that polypectomy should be considered in infertile women.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
endometrium polyp
infertilitás
hiszteroskópia
reprodukció
Megjelenés:Archives of Gynecology and Obstetrics. - 300 : 1 (2019), p. 217-221. -
További szerzők:Molnár Szabolcs (1987-) (szülész-nőgyógyász szakorvos) Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus) Herman Tünde (1979-) (orvos) Singh, Jashanjeet (1976-) (szülész-nőgyógyász szakorvos) Török Péter (1975-) (szülész-nőgyógyász)
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12.

001-es BibID:BIBFORM104992
Első szerző:Lukács Luca (hallgató)
Cím:Out-patient selective tubal test with concomitant evaluation of the uterine cavity / Luca Lukács, Judit Lőrincz, Bence Boldogh, Márton György Lipták, Tünde Herman, Péter Török
Dátum:2022
Megjegyzések:Background Infertility is a common problem of couples with reproductive age. Tubal abnormality is an important cause of infertility, accounting for 25%?35% of female infertility. Tubal patency testing is important during infertility work-up before any assisted reproductive technique is performed. The relevance of diagnostic hysteroscopy, especially when performed in an outpatient "office" setting, in the evaluation process of infertility has increased in the last few years. During diagnostic hysteroscopy any morphological change of the uterine cavity or endometrium can be detected, not to mention the possibility for the tubal patency test. Our aim was to investigate the results of women who underwent selective pertubation with office hysteroscopy. Methods A total of 212 women were included in this retrospective study, who chose diagnostic office hysteroscopy during their infertility work-up. In each case before and after the procedure 3D ultrasound was used for evaluation of the uterine cavity. The selective pertubation with office hysteroscopy was performed in an outpatient setting, without general anaesthesia. Results Primary infertility (in 75 %), secondary infertility (in 22,17 %), repeated abortions (in 1,89 %), positive ultrasound results (in 0,94 % of the cases) made the indication for office hysteroscopy. The mean age of the patients was 33.1 ? 4.77. During the evaluation of uterine cavity 13 cases required polypectomy as well and 1 patient needed uterine myomectomy. Endometrial visualisation of 39 cases indicated biopsy as well during the evaluation with office hysteroscopy, this way 8 chronic endometritis were detected. Regarding the selective pertubation test, we detected positivity (tubal abnormality) in 61,32 % of the study, among them we explored unilateral occlusion in 43,08 % of the cases and bilateral occlusion in 56,92 % of the patients. No complications occurred during the 212 diagnostic office hysteroscopies. Conclusions Our results suggest this novel method, selective pertubation with office hysteroscopy, which is an effective, accurate, minimally invasive method to investigate tubal patency, in outpatient circumstances in order to choose proper assisted reproductive techniques. This way the complications of general anaesthesia or radiation (HSG) can be avoided. Moreover, with the examination of the uterine cavity, other factors, such as polyps, micropolyps, fibroids, chronic endometritis can be detected and treated so fertility can be improve as well.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:Facts, views & vision in ObGyn. - 14 : 3 (2022), p. P124. -
További szerzők:Lőrincz Judit (1988-) (általános orvos) Boldogh Bence Zoltán (1995-) (Orvos) Lipták Márton György (1988-) (Orvos) Herman Tünde (1979-) (orvos) Török Péter (1975-) (szülész-nőgyógyász)
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