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1.

001-es BibID:BIBFORM105089
Első szerző:Berczi Adrienne
Cím:Genetic concerns and other offsping health safety issues of assisted reproduction : a literature review = Az asszisztált reprodukcióval fogant terhességeivel és az abból született utódok genetikai, valamint egyéb betegségeivel kapcsolatos ismeretek - irodalmi áttekintés / Adrienne Berczi, Satomi Sakamoto, Szilvia Csehely, Tünde Herman, Attila Jakab
Dátum:2022
Megjegyzések:Although the study of assisted reproduction of mammals can be traced back to the 19th century and human research also began in the 1940s, but clinical application of the in vitro fertilization (IVF) was first successful in 1978 in England. Since then, assisted reproductive techniques (ART) made rapid progress and has become an accessible treatment for couples who have infertility problems. Nowadays it is one of the most important options for treatment of several types of male and female infertility, as well it is positioned as a treatment for unexplained infertility. While today it is widely accessible technique, as the time passes several complications are revealed both in women who had ART treatment and related to offspring who were born after ART. ART-derived infants have more preterm and low birth weight complications than spontaneous pregnancies. The number of children born after ART is increasing and their health condition is studied with particular interest. Long-term complications related to ART are also revealed such as increasing number of malformations, genetic disorders, metabolic and neoplastic problems in children. The aim of this review paper is to investigate the relationship between ART, perinatal outcome and offspring health status.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban
folyóiratcikk
assisted reproduction
perinatal outcome
offspring health
Megjelenés:Magyar Andrológia. - 2022 : 1 (2022), p. 15-27. -
További szerzők:Sakamoto, Satomi Csehely Szilvia (1990-) (szülész-nőgyógyász szakorvos) Herman Tünde (1979-) (orvos) Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus)
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2.

001-es BibID:BIBFORM117861
Első szerző:Herman Tünde (orvos)
Cím:Hashimoto's thyroiditis negatively influences ICSI outcome in euthyroid women on T4 substitution therapy; a retrospective study / Tünde Herman, Péter Török, Antonio Simone Laganà, Vito Chiantera, Renato Venezia, Attila Jakab
Dátum:2024
ISSN:0378-7346
Megjegyzések:Abstract Objective: To analyze the impact of thyroid autoimmunity (TAI) on reproductive outcome parameters of ICSI cycles as compared to TAI negative ICSI cycles. Design: In this single IVF center retrospective study 86 infertile women with elevated TPOAb or TGAb levels, but euthyroid after thyroxine replacement (study group), were compared to 69 female patients with no thyroid abnormalities (controls). Following ICSI treatment fertilization rate (FR), clinical pregnancy rate (CPR), miscarriage rate (MR) and live birth rate (LBR) were analyzed. Materials, Setting, Methods: All subjects with various infertility factors were treated with ICSI in university based IVF center. Patients in the study group received thryroxine replacement and were euthyreoid at IVF treatment. Before the IVF cycles endocrinological parameters were uniformly assessed: thyroid function and antibodies, reproductive hormones (AMH, FSH, LH, E2, PRL, testosterone, DHEAS, 17-OHP, AD) and OGTT (0-60-120 min glucose and insulin). Following descriptive comparison of laboratory parameters, age adjusted analyses of FR, CPR, MR and LBR were performed. Results: TAI positive women were older (mean age 35.31?4.95 vs. 32.15?4.87 years; p=0.002), had higher FSH (8.4?3.4 vs. 7.4?2.32 U/L; p=0.024), higher E2 (53.94?47.61 vs. 42.93?18.92 pg/ml; p=0.025) levels, while AMH (2.88?2.62 vs. 3.61?1.69 ng/ml; p=0.0002) was lower. There were no differences in TSH levels (1.64?0.96 vs. 1.66?0.65 uIU/ml; p=0.652) between the two groups. FT3 (2.63?0.58 vs. 2.98?0.55 pg/ml; p=0.002) was lower and FT4 (1.3?0.29 vs. 1.13?0.21 ng/dl; p=0.0002) was higher in the TAI positive group, reflecting clinically irrevelant differences. Egg cell counts (6?3.8 vs. 7.5?3.95; p=0.015) were lower in TAI and remained so following age adjustment. Although the overall ICSI FR did not differ (62.9 % vs. 69.1 %, p=0.12), it was lower for patients under 35 with TAI showing decreasing differences in line with age. The CPR (36.04 % vs. 69.56 %; p<0.001), LBR (23.25 % vs. 60.86 %; p<0.001) were lower, the MR (35.48 % vs. 12.5 %; p=0.024) was higher in the TAI group and these differences remained after age adjustment. Limitations: Since the higher age of the study group may interfere with the effect of TAI, age adjustment calculations were necessary to perform to eliminate this confounding factor. Conclusion: Despite optimal thyroid supplementation in clinical or subclinical hypothyreoidism, the presence of TAI negatively influences clinical pregnancy rate and is connected to a higher miscarriage rate, thus resulting in a lower live birth rate after ICSI. Decreased fertilization rate with ICSI in TAI patients may also contribute to poorer outcomes, especially in younger women.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
IVF
ICSI
Hashimoto thyreoiditis
Megjelenés:Gynecologic And Obstetric Investigation. - [Epub ahead of print] (2024). -
További szerzők:Török Péter (1975-) (szülész-nőgyógyász) Laganà, Antonio Simone Chiantera, Vito Venezia, Renato Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus)
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3.

001-es BibID:BIBFORM105360
035-os BibID:(WoS)000894986300001 (Scopus)85143521697
Első szerző:Herman Tünde (orvos)
Cím:Impact of endocrine disorders on IVF outcomes : results from a large, single-centre, prospective study / T. Herman, Sz. Csehely, M. Orosz, H. P. Bhattoa, T. Deli, P. Török, A. S. Laganà, V. Chiantera, A. Jakab
Dátum:2023
ISSN:2045-2322
Megjegyzések:Endocrine disorders negatively influence the ovarian function and increasing incidence of endocrine diseases with age may have further negative effects on pregnancy rate. Prospective cohort study of 231 consecutively enrolled patients underwent IVF treatment. In patients with known endocrine disorders the laboratory parameters were corrected before IVF treatment. 161 patients (69.7%) had at least one known and treated endocrine disorder (study group), and 70 patients were endocrine negative (control group). Endocrine disorders diagnosed were thyroid disorders (32,5%), diminished ovarian reserve (23,8%), insulin resistance (22,5%), PCOS (15,2%), hyperprolactinemia (13,4%), obesity (12,1%), hypogonadotropic hypogonadism (0,8%), congenital adrenal hyperplasia (0.2%). Before the IVF treatment systematic endocrine laboratory examinations were performed in all patients. Higher age, BMI, and FSH was found in the study group, while AMH level was lower. There were no differences in LH, E2, prolactin, TSH, FT3, FT4, TT, DHEAS, androstendione, 17-OHP, SHBG level between the study and control groups. The study group had higher baseline glucose, baseline insulin, 120 minute glucose and 120 minute insulin level after oral glucose tolerance test. With no difference in the IVF cycles performed, pregnancy rate was lower in the study group (61.43 % vs. 34.16 %; p=0.003), and this difference (p=0.0151) remained in age-corrected rates, as well. The analysis were also performed in individual endocrinology groups. The prevalence of endocrine disorders is high in females participating in IVF programs and they often accompanying to each other. Even after proper correction, the presence of the endocrine disorder negatively influences the pregnancy rate in IVF treatment.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
assisted reproduction
in vitro fertilization
endocrine diseases
thyroid diseases
Megjelenés:Reproductive Sciences. - 30 : 6 (2023), p. 1878-1890. -
További szerzők:Csehely Szilvia (1990-) (szülész-nőgyógyász szakorvos) Orosz Mónika (1991-) (Szülész-nőgyógyász) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Deli Tamás Török Péter (1975-) (szülész-nőgyógyász) Laganà, Antonio Simone Chiantera, Vito Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus)
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4.

001-es BibID:BIBFORM101643
035-os BibID:(scopus)85129214860 (wos)000795847700003
Első szerző:Herman Tünde (orvos)
Cím:Endokrin kórképek előfordulása és társulása in vitro fertilizációs programban részt vevő nők körében / Herman Tunde, Csehely Szilvia, Orosz Monika, Bhattoa Harjit Pal, Deli Tamás, Török Péter, Jakab Attila
Dátum:2022
ISSN:0030-6002 1788-6120
Tárgyszavak:Orvostudományok Klinikai orvostudományok magyar nyelvű folyóiratközlemény hazai lapban
folyóiratcikk
Megjelenés:Orvosi Hetilap. - 163 : 18 (2022), p. 712-719. -
További szerzők:Csehely Szilvia (1990-) (szülész-nőgyógyász szakorvos) Orosz Mónika (1991-) (Szülész-nőgyógyász) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Deli Tamás (1979-) (szülész-nőgyógyász, endokrinológus szakorvos) Török Péter (1975-) (szülész-nőgyógyász) Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus)
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5.

001-es BibID:BIBFORM088442
Első szerző:Herman Tünde (orvos)
Cím:In Vitro Fertilization Treatment of a Patient with Primary Partial Empty Sella and Other Co-Factors / Tünde Herman, Péter Török, Antonio Simone Laganȧ, Attila Jakab
Dátum:2020
ISSN:2377-9004
Megjegyzések:We report the case of a patient with primary empty sella, who had successful assisted reproductive treatment. The patient is a 28-years-old infertile female with primary amenorrhoea and hypogonadotropic hypogonadism. Serum FSH, LH, E2 indicated central anovulation, but the production of GH, ACTH, TSH and PRL were normal. Obesity and insulin resistance were present. Male partner had asthenozoo-teratospermia and hyperprolactinaemia. After three failed intrauterine inseminations, she was addressed to gynecologic endocrinology where cerebral MRI was done, which revealed partial empty sella. Due to the combination of several infertility factors, the couple was referred for IVF. Since the initial fertilization rate was low at IVF-ICSI and implantation failed, intensive lifestyle modification and endocrinological care was introduced for 5 months, then the second IVF treatment was effective and, after a relatively uneventful pregnancy, healthy twin boys were born near-term.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Hypogonadotropic hypogonadism (HH)
Primary empty sella (PES)
Astheno-teratozoospermia (AT)
In vitro fertilization (IVF)
Megjelenés:Obstetrics and Gynaecology Cases - Reviews. - 7 : 5 (2020), p. 1-6. -
További szerzők:Török Péter (1975-) (szülész-nőgyógyász) Laganà, Antonio Simone Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus)
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6.

001-es BibID:BIBFORM078274
Első szerző:Lőrincz Judit (általános orvos)
Cím:The effect of localization and histological verification of endometrial polyps on infertility / Judit Lőrincz, Szabolcs Molnár, Attila Jakab, Tünde Herman, Singh Jashanjeet, Péter Török
Dátum:2019
ISSN:0932-0067 1432-0711
Megjegyzések:Aim Our purpose is to investigate if transcervical resection of endometrial polyps improves the fertility in ovulatory infertile women, and whether polyp histology, intrauterine location, and the technique of polypectomy have any influence on the pregnancy rates. Methods In this retrospective study, clinical data of 87 ovulatory infertile women who underwent hysteroscopy and pol- ypectomy, and their 12-month follow-up have been analyzed. Subgroups according to the method of polyp removal (resec- toscope or curettage), the polyp localization (utero-tubal, anterior, posterior, lateral, multiple) and the histological result were interpreted. Results Meanageofpatientswas33.99?4.24years.TherewerenodifferencesintheBMIandbasalFSHlevelsbetweenthe subgroups. Pregnancy was recorded in 30 (34.5%) within the next 12 months without any difference between the subgroups of polypectomy method applied. Posterior wall polyp resection increased the pregnancy chance (OR 5.02), but no other dif- ferences were observed in 1-year pregnancy rates to other localizations. Removal of polyps which had normal endometrial histology had lower pregnancy rates as compared to that of polyps with hyperplasia or endometrial polyp histology results (OR 0.25). Conclusions Polypectomy improved the conception rate in the subsequent year regardless of the intrauterine localization and the method of its surgical removal. Therefore, we can conclude that polypectomy should be considered in infertile women.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
endometrium polyp
infertilitás
hiszteroskópia
reprodukció
Megjelenés:Archives of Gynecology and Obstetrics. - 300 : 1 (2019), p. 217-221. -
További szerzők:Molnár Szabolcs (1987-) (szülész-nőgyógyász szakorvos) Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus) Herman Tünde (1979-) (orvos) Singh, Jashanjeet (1976-) (szülész-nőgyógyász szakorvos) Török Péter (1975-) (szülész-nőgyógyász)
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