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001-es BibID:BIBFORM034846
Első szerző:Lengyel Szabolcs (belgyógyász)
Cím:The impact of serum homocysteine on intima-media thickness in normotensive, white-coat and sustained hypertensive adolescents / Lengyel S., Katona E., Zatik J., Molnár C., Paragh G., Fülesdi B., Páll D.
Dátum:2012
ISSN:0803-7051
Megjegyzések:In recent decades, elevated levels of homocysteine (Hcy) have been found to be associated with an increased risk of vascular events. Additionally, in some case-control studies, hyperhomocysteinaemia has been found to be related to higher intima-media thickness (IMT), but the results are inconclusive. Therefore, in the present study we intended to assess the relationship between serum levels of Hcy and IMT in normotensive and hypertensive adolescents. Patients and methods. 59 normotensive 47 white coat hypertensive and 73 sustained hypertensive adolescents were included in our study. IMT of the common carotid arteries was measured by B-mode ultrasonography. Plasma NOx as well as homocysteine levels were measured in all cases. The relationship between IMT and Hcy and NOx were assessed by a pooled analysis. Additionally, serum levels of Hcy and NOx were compared between normotensives and hypertensive subgroups. Results. IMT was elevated in hypertensive adolescents (means ± SD: 0.055 ± 0.01 cm) compared with normotensives (0.048 ± 0.008 cm, p < 0.01). Higher serum concentrations of homocysteine were measured in hypertensive teenagers (11.9 ± 7.25 micromol/l for hypertensive and 9.85 ± 3.12 micromol/l for normotensives respectively, p < 0.01). In contrast to this, serum NOx was lower in patients (28.8 ± 14.9 micromol/l) compared with controls (38.8 ± 7.6 micromol/l, p < 0.01). The pooling of homocysteine and IMT data of hypertensive and normotensive adolescents revealed a significant positive relationship between the two parameters (r = 0.43, p < 0.001). Conclusions. We conclude that elevated serum levels of homocysteine may play a role in increased IMT in adolescent hypertension.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Blood Pressure. - 21 : 1 (2012), p. 39-44. -
További szerzők:Katona Éva (1967-) (belgyógyász, diabetológus) Zatik János (1961-) (szülész-nőgyógyász) Molnár Csilla (1962-) (aneszteziológus) Paragh György (1953-) (belgyógyász) Fülesdi Béla (1961-) (aneszteziológus) Páll Dénes (1967-) (belgyógyász, kardiológus)
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2.

001-es BibID:BIBFORM102086
035-os BibID:(cikkazonosító)e0268525 (WOS)000835048800009 (Scopus)85130851932
Első szerző:Molnár Csilla (aneszteziológus)
Cím:Takotsubo cardiomyopathy in patients suffering from acute non-traumatic subarachnoid hemorrhage : A single center follow-up study / Molnár Csilla, Gál Judit, Szántó Dorottya, Fülöp László, Szegedi Andrea, Siró Péter, Nagy V. Endre, Lengyel Szabolcs, Kappelmayer János, Fülesdi Bela
Dátum:2022
ISSN:1932-6203
Megjegyzések:Background Takotsubo cardiomyopathy (TTC) is an important complication of subarachnoid hemorrhage (SAH), that may delay surgical or endovascular treatment and may influence patient outcome. This prospective follow-up study intended to collect data on the prevalence, severity, influencing factors and long-term outcome of TTC in patients suffering from non-traumatic SAH. Methods Consecutive patients admitted with the diagnosis of non-traumatic SAH were included. Intitial assessment consisted of cranial CT, Hunt-Hess, Fisher and WFNS scoring, 12-lead ECG, transthoracic echocardiography (TTE), transcranial duplex sonography and collecting laboratory parameters (CK, CK-MB, cardiac troponin T, NT-proBNP and urine metanephrine and normetanephrine). Diagnosis of TTC was based on modified Mayo criteria. TTC patients were dichotomized to mild and severe forms. Follow-up of TTE, Glasgow Outcome Scale assessment, Barthel's and Karnofsky scoring occurred on days 30 and 180. Results One hundred thirty six patients were included. The incidence of TTC in the entire cohort was 28.7%; of them, 20.6% and 8.1% were mild and severe, respectively. TTC was more frequent in females (30/39; 77%) than in males (9/39; 23%) and was more severe. The occurrence of TTC was related to mFisher scores and WFNS scores. Although the severity of TTC was related to mFisher score, Hunt-Hess score, WFNS score and GCS, multivariate analysis showed the strongest relationship with mFisher scores. Ejection fraction differences between groups were present on day 30, but disappeared by day 180, whereas wall motion score index was still higher in the severe TTC group at day 180. By the end of the follow-up period (180 days), 70 (74.5%) patients survived in the non-TTC, 22 (81.5%) in the mild TTC and 3 (27%) in the severe TTC group (n = 11) (p = 0.002). At day 180, GOS, Barthel, and Karnofsky outcome scores were higher in patients in the control (non-TTC) and the mild TTC groups than in the severe TTC group. Conclusions Takotsubo cardiomyopathy is a frequent finding in patients with SAH, and severe TTC may be present in 8% of SAH cases. The severity of TTC may be an independent predictor of mortality and outcome at 6 months after disease onset. Therefore, a regular follow-up of ECG and TTE abnormalities is warranted in patients with subrachnoid hemorrhage for early detection of TTC.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Plos One. - 17 : 5 (2022), p. 1-20. -
További szerzők:Gál Judit (1977-) (aneszteziológiai és ITO szakorvos) Szántó Dorottya (1991-) (aneszteziológus, intenzív terápiás szakorvos) Fülöp László (1976-) (kardiológus) Szegedi Andrea (kardiológus) Siró Péter (1973-) (neurológus, aneszteziológus, intenzív terápiás szakorvos) Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Lengyel Szabolcs (1981-) (belgyógyász) Kappelmayer János (1960-) (laboratóriumi szakorvos) Fülesdi Béla (1961-) (aneszteziológus)
Pályázati támogatás:Nemzeti Agykutatási Projekt
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3.

001-es BibID:BIBFORM034848
Első szerző:Páll Dénes (belgyógyász, kardiológus)
Cím:Impaired cerebral vasoreactivity in white coat hypertensive adolescents / Páll Dénes, Lengyel Szabolcs, Komonyi Éva, Molnár Csilla, Paragh György, Fülesdi Béla, Katona Éva
Dátum:2011
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:European Journal of Neurology. - 18 : 4 (2011), p. 584-589. -
További szerzők:Lengyel Szabolcs (1981-) (belgyógyász) Komonyi Éva Molnár Csilla (1962-) (aneszteziológus) Paragh György (1953-) (belgyógyász) Fülesdi Béla (1961-) (aneszteziológus) Katona Éva (1967-) (belgyógyász, diabetológus)
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4.

001-es BibID:BIBFORM016773
Első szerző:Páll Dénes (belgyógyász, kardiológus)
Cím:Assessment of target-organ damage in adolescent white-coat and sustained hypertensives / Páll Dénes, Juhász Mária, Lengyel Szabolcs, Molnár Csilla, Paragh György, Fülesdi Béla, Katona Éva
Dátum:2010
ISSN:0263-6352
Megjegyzések:The aim of the present study was to assess whether a difference exists between intima-media thickness and the left ventricular mass index in healthy nonhypertensive, white-coat hypertensive and sustained hypertensive adolescents. PATIENTS AND METHODS: Fifty-nine normotensive and 120 hypertensive adolescents were enrolled in our study. Hypertensive patients were classified into white-coat hypertension (WCH) and sustained hypertension groups based on 24-h ambulatory blood pressure measurements. Both normotensive and hypertensive individuals underwent routine laboratory tests, intima-media thickness measurements on the common carotid arteries and transthoracic echocardiography to measure the left ventricular mass index (LVMI). RESULTS: Intima-media thickness was higher both in WCH and sustained hypertension compared with healthy normotensive individuals (controls: 0.048 ± 0.01 cm, WCH: 0.056 ± 0.01 cm, sustained hypertension: 0.054 ± 0.012 cm, both P < 0.001 compared with controls, nonsignificant difference between the two hypertensive groups). There was no difference between the LVMI of control individuals and WCH (LVMI: 35.5 ± 10.3 g/m and 37.7 ± 11.2 g/m respectively, P = 0.87). LVMI in sustained hypertension group (LVMI: 44.1 ± 14.1 g/m) was significantly higher both compared with WCH (P < 0.05), and healthy adolescents (P < 0.001). CONCLUSION: Target-organ damage develops in a stepwise fashion in adolescent hypertension. An increased intima-media thickness can be demonstrated not only in the sustained but also in the white-coat form of adolescent hypertension.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Journal Of Hypertension. - 28 : 10 (2010), p. 2139-2144. -
További szerzők:Juhász Mária (1975-) (belgyógyász) Lengyel Szabolcs (1981-) (belgyógyász) Molnár Csilla (1962-) (aneszteziológus) Paragh György (1953-) (belgyógyász) Fülesdi Béla (1961-) (aneszteziológus) Katona Éva (1967-) (belgyógyász, diabetológus)
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5.

001-es BibID:BIBFORM062339
Első szerző:Sárkány Péter (aneszteziológus)
Cím:Non-invasive pulse wave analysis for monitoring the cardiovascular effects of CO2 pneumoperitoneum during laparoscopic cholecystectomy- a prospective case-series study / Sárkány Péter, Lengyel Szabolcs, Nemes Réka, Orosz Lívia, Páll Dénes, Molnár Csilla, Fülesdi Béla
Dátum:2014
ISSN:1471-2253
Megjegyzések:AbstractBackground: Peritoneal insufflation results in hemodynamic changes during laparoscopic cholecystectomy.The aim of the present work is to test whether non-invasive applanation tonometry is suitable for reflectingthese hemodynamic alterations.Methods: 41 patients undergoing laparoscopic cholecystectomies were monitored using the SphygmoCor pulsewave analysing system. Peripheral blood pressures (PBP), central aortic blood pressures (CBP), augmentation index(ALX@HR75) and subendocardial viability ratio (SVR) were measured at rest (Phase 1), after anesthetic induction(Phase 2), after peritoneal inflation (Phase 3) and after peritoneal deflation (Phase 4).Results: Induction of anesthesia resulted in a statistically significant reduction in both the peripheral blood pressureand central aortic pressures, accompanied by a decrease in augmentation pressure and augmentation index.Peripheral blood pressures did not change along with the peritoneal cavity insufflation, except for a moderateincrease in systolic blood pressure. In contrast to this, an increase could be observed in central aortic pressure(106.77 ? 18.78 vs. 118.05 ? 19.85 mmHg, P < 0.01) which was accompanied by increased augementation pressure(18.97 ? 10.80 vs. 31.55 ? 12.01; P < 0.001) and augmentation index (7.31 ? 5.59 vs. 12.61 ? 7.56, P < 0.001), indicatinga rise in peripheral arterial stiffness.Conclusions: The Sphigmocor pulse wave analysis system can be reliably used for detecting and monitoringcardiovascular changes occurring during laparoscopic cholecystectomy.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Laparoscopic cholecystectomy
Hemodynamic changes
Applanation tonometry
Megjelenés:BMC Anesthesiology. - 14 : 98 (2014), p. 1-7. -
További szerzők:Lengyel Szabolcs (1981-) (belgyógyász) Nemes Réka (1985-) (aneszteziológus, intenzív terápiás szakorvos) Orosz Lívia Páll Dénes (1967-) (belgyógyász, kardiológus) Molnár Csilla (1962-) (aneszteziológus) Fülesdi Béla (1961-) (aneszteziológus)
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