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001-es BibID:BIBFORM035326
Első szerző:Móré Csaba (szülész-nőgyógyász)
Cím:The effects of pregnancy and lactation on hormonal status and biochemical markers of bone turnover / Csaba More, Harjit P. Bhattoa, Péter Bettembuk, Ádám Balogh
Dátum:2003
ISSN:03012115
Megjegyzések:Introduction: Biochemical markers of bone turnover are reliable indices for measuring changes in bone formation and bone resorption. Due to limitations in the use of bone densitometry during pregnancy biochemical markers of bone turnover provide an excellent alternative to examine the state of the skeleton during this physiologic state. Study design: We performed a prospective study in 20 women, during their first full term pregnancy until 12 months postpartum, intending to breast feed for 12 (mean, 9.1; range, 7-12) months postpartum. Morning blood and urine samples were obtained for laboratory tests: within 3 months before conception (baseline); between 22 and 24 gestational weeks; after delivery, and 6 and 12 months postpartum. Serum 25-hydroxyvitamin D (25-OH-D), parathyroid hormone (PTH), bone specific alkaline phosphatase, osteocalcin (OC), procollagen I carboxypeptides, calcium, phosphate and creatinine in addition to urine deoxypyridinoline crosslinks and calcium were measured. Results: There was no significant difference in the values of urinary calcium/creatinine and serum calcium, phosphate and 25-OH-D between the different visits during the study. In our patients there was a significant increase in PTH levels at 12 months postpartum as compared to baseline, although the mean values remained in the PTH reference range. All bone turnover markers increased during pregnancy and failed to reach baseline level even 12 months postpartum. Conclusion: The high maternal bone turnover may suggest that the calcium needed for infant growth during pregnancy and lactation may be drawn at least in part from the maternal skeleton. ?? 2002 Elsevier Science Ireland Ltd. All rights reserved.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Bone biochemical markers
Hormonal status
Lactation
Pregnancy
25 hydroxyvitamin D
alkaline phosphatase
biochemical marker
deoxypyridinoline
osteocalcin
parathyroid hormone
procollagen c proteinase
adult
article
blood sampling
bone turnover
breast milk
calcium blood level
calcium urine level
clinical article
conception
controlled study
creatinine urine level
delivery
female
gestational age
hormone metabolism
hormone urine level
human
laboratory test
lactation
normal value
parathyroid hormone blood level
phosphate blood level
pregnancy
priority journal
puerperium
statistical significance
third trimester pregnancy
urinalysis
vitamin blood level
Adult
Alkaline Phosphatase
Amino Acids
Bone Remodeling
Calcifediol
Calcium
Cohort Studies
Creatinine
Female
Humans
Lactation
Osteocalcin
Parathyroid Hormone
Peptide Fragments
Phosphates
Pregnancy
Procollagen
Prospective Studies
egyetemen (Magyarországon) készült közlemény
Megjelenés:European Journal of Obstetrics Gynecology and Reproductive Biology. - 106 : 2 (2003), p. 209-213. -
További szerzők:Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Bettembuk Péter Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos)
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