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001-es BibID:BIBFORM035054
035-os BibID:PMID:22422303
Első szerző:Bhattoa Harjit Pal (laboratóriumi szakorvos)
Cím:Prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in healthy Hungarian men over 50 years of age : the HunMen Study / H. P. Bhattoa, E. Nagy, C. More, J. Kappelmayer, A. Balogh, E. Kalina, P. Antal-Szalmas
Dátum:2013
ISSN:0937-941X
Megjegyzések:This study reports a high prevalence of hypovitaminosis D and low bone mineral density (BMD) in a healthy Hungarian male cohort over 50 years of age. Men with 25-hydroxyvitamin D levels of <75 nmol/L had a significantly higher 10-year hip and major osteoporotic fracture probability using the country-specific fracture risk assessment (FRAX) algorithm. INTRODUCTION: The aim of this study is to characterize the prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in healthy Hungarian men over 50 years of age. METHODS: We determined levels of 25-hydroxyvitamin D (25-OH-D), PTH, osteocalcin (OC), C-terminal telopeptides of type-I collagen (CTX-I), procollagen type 1 amino-terminal propeptide (PINP), BMD at L1-L4 (LS) and femur neck (FN), daily dietary calcium intake, and the 10-year probability of hip fracture and a major osteoporotic fracture using the country-specific FRAX algorithm in 206 randomly selected ambulatory men. RESULTS: The mean (range) age of the volunteers was 60 (51-81) years. The prevalence of hypovitaminosis D (25-OH-D, <75 nmol/L) was 52.9%. The mean (range) FRAX hip fracture and FRAX major osteoporotic fracture was 0.8% (0-9.4%) and 3.8% (1.7-16%), respectively. On comparing the vitamin D sufficient to the insufficient group, there was a statistically significant difference between the FRAX hip fracture and FRAX major osteoporotic fracture indexes. There was significant seasonal variation in the vitamin D levels; the lowest levels were measured in winter and the highest in summer. CONCLUSIONS: A high prevalence of hypovitaminosis D and low BMD were observed in the studied Hungarian male population. This is the first study reporting higher 10-year hip and major osteoporotic fracture probability using the country-specific FRAX algorithm in individuals with hypovitaminosis D.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Molekuláris Medicina
Megjelenés:Osteoporosis International. - 24 : 1 (2013), p. 179-186. -
További szerzők:Nagy E. Móré Csaba (1971-) (szülész-nőgyógyász) Kappelmayer János (1960-) (laboratóriumi szakorvos) Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos) Kalina Edit Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos)
Pályázati támogatás:TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
Celluláris hematológia - immunológia
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elektronikus változat
DOI
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2.

001-es BibID:BIBFORM039080
Első szerző:Móré Csaba (szülész-nőgyógyász)
Cím:The effects of pregnancy and lactation on bone mineral density / Móré Cs., Bhattoa H. P., Jakab A., Balogh A., Tóth Z.
Dátum:2008
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:Acta Obstetrica e Ginecologica Portoguesa. - Suppl. 1. (2008), p. 72. -
További szerzők:Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus) Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos) Tóth Zoltán (1948-) (szülész-nőgyógyász, humángenetikus)
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3.

001-es BibID:BIBFORM035374
035-os BibID:WOS:000183123300472
Első szerző:Móré Csaba (szülész-nőgyógyász)
Cím:The effects of pregnancy and lactation on hormonal status and biochemical markers of bone turnover / More, C., Bhattoa, H. P., Bettembuk, P., Balogh, Á.
Dátum:2003
ISSN:8756-3282
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Endocrinology & Metabolism
egyetemen (Magyarországon) készült közlemény
Megjelenés:Bone. - 32 : 5 (2003), p. S180. -
További szerzők:Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Bettembuk Péter Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos)
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4.

001-es BibID:BIBFORM035326
Első szerző:Móré Csaba (szülész-nőgyógyász)
Cím:The effects of pregnancy and lactation on hormonal status and biochemical markers of bone turnover / Csaba More, Harjit P. Bhattoa, Péter Bettembuk, Ádám Balogh
Dátum:2003
ISSN:03012115
Megjegyzések:Introduction: Biochemical markers of bone turnover are reliable indices for measuring changes in bone formation and bone resorption. Due to limitations in the use of bone densitometry during pregnancy biochemical markers of bone turnover provide an excellent alternative to examine the state of the skeleton during this physiologic state. Study design: We performed a prospective study in 20 women, during their first full term pregnancy until 12 months postpartum, intending to breast feed for 12 (mean, 9.1; range, 7-12) months postpartum. Morning blood and urine samples were obtained for laboratory tests: within 3 months before conception (baseline); between 22 and 24 gestational weeks; after delivery, and 6 and 12 months postpartum. Serum 25-hydroxyvitamin D (25-OH-D), parathyroid hormone (PTH), bone specific alkaline phosphatase, osteocalcin (OC), procollagen I carboxypeptides, calcium, phosphate and creatinine in addition to urine deoxypyridinoline crosslinks and calcium were measured. Results: There was no significant difference in the values of urinary calcium/creatinine and serum calcium, phosphate and 25-OH-D between the different visits during the study. In our patients there was a significant increase in PTH levels at 12 months postpartum as compared to baseline, although the mean values remained in the PTH reference range. All bone turnover markers increased during pregnancy and failed to reach baseline level even 12 months postpartum. Conclusion: The high maternal bone turnover may suggest that the calcium needed for infant growth during pregnancy and lactation may be drawn at least in part from the maternal skeleton. ?? 2002 Elsevier Science Ireland Ltd. All rights reserved.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Bone biochemical markers
Hormonal status
Lactation
Pregnancy
25 hydroxyvitamin D
alkaline phosphatase
biochemical marker
deoxypyridinoline
osteocalcin
parathyroid hormone
procollagen c proteinase
adult
article
blood sampling
bone turnover
breast milk
calcium blood level
calcium urine level
clinical article
conception
controlled study
creatinine urine level
delivery
female
gestational age
hormone metabolism
hormone urine level
human
laboratory test
lactation
normal value
parathyroid hormone blood level
phosphate blood level
pregnancy
priority journal
puerperium
statistical significance
third trimester pregnancy
urinalysis
vitamin blood level
Adult
Alkaline Phosphatase
Amino Acids
Bone Remodeling
Calcifediol
Calcium
Cohort Studies
Creatinine
Female
Humans
Lactation
Osteocalcin
Parathyroid Hormone
Peptide Fragments
Phosphates
Pregnancy
Procollagen
Prospective Studies
egyetemen (Magyarországon) készült közlemény
Megjelenés:European Journal of Obstetrics Gynecology and Reproductive Biology. - 106 : 2 (2003), p. 209-213. -
További szerzők:Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Bettembuk Péter Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos)
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5.

001-es BibID:BIBFORM035330
Első szerző:Móré Csaba (szülész-nőgyógyász)
Cím:The effects of pregnancy and lactation on bone mineral density / C. More, P. Bettembuk, H. P. Bhattoa, A. Balogh
Dátum:2001
ISSN:0937-941X
Megjegyzések:We performed a prospective study of bone mineral density (BMD) in 38 women during their first full-term pregnancy until 12 months postpartum. BMD measurements at lumbar spine [L2-L4 (LS)] and forearm [distal 33% (RD) and ultradistal (RUD) region of the radius] were made within 3 months before conception, after delivery, and at 6 and 12 months postpartum. In mid-pregnancy the DXA examination was carried out only at the forearm. Patients were grouped according to duration of lactation as group I, II or III (0-1, 1-6, 6-12 months respectively). During pregnancy there was a significant difference between baseline and delivery (p<0.001) in the LS, RUD and RD BMD values. In group I there was no statistically significant difference in LS BMD between visits following pregnancy. The RUD BMD loss was recovered by 6 months postpartum (PP6). Group II showed continuous bone loss from delivery until PP6 at LS and RUD. In group III the LS BMD loss continued throughout the lactation period. The RUD BMD dropped (4.9%) until PP6 then increased by 3.0% as measured at 12 months postpartum (PP12). There was no significant change in RD BMD in any of three groups during lactation. At LS bone loss between delivery and PP12 correlated well with the duration of lactation (r=-0.727; p<0.001). We suggest that calcium needed for fetal skeletal growth during pregnancy was gained from maternal trabecular and cortical sites and that calcium needed for infant growth during lactation was drawn mainly from the maternal trabecular skeleton in our patients. The effect of pregnancy and lactation on the maternal bone mass was spontaneously compensated after weaning.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Bone mineral density
Lactation
Pregnancy
adult
article
bone atrophy
bone density
bone growth
bone mineralization
calcium mobilization
controlled study
cortical bone
dual energy X ray absorptiometry
female
fetus growth
human
lactation
lumbar spine
pregnancy
priority journal
puerperium
trabecular bone
weaning
Adult
Bone Density
Densitometry, X-Ray
Female
Humans
Lactation
Pregnancy
Prospective Studies
egyetemen (Magyarországon) készült közlemény
Megjelenés:Osteoporosis International. - 12 : 9 (2001), p. 732-737. -
További szerzők:Bettembuk Péter Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos)
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Intézményi repozitóriumban (DEA) tárolt változat
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