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001-es BibID:	BIBFORM035054
035-os BibID:	PMID:22422303
Első szerző:	Bhattoa Harjit Pal (laboratóriumi szakorvos)
Cím:	Prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in healthy Hungarian men over 50 years of age : the HunMen Study / H. P. Bhattoa, E. Nagy, C. More, J. Kappelmayer, A. Balogh, E. Kalina, P. Antal-Szalmas
Dátum:	2013
ISSN:	0937-941X
Megjegyzések:	This study reports a high prevalence of hypovitaminosis D and low bone mineral density (BMD) in a healthy Hungarian male cohort over 50 years of age. Men with 25-hydroxyvitamin D levels of <75 nmol/L had a significantly higher 10-year hip and major osteoporotic fracture probability using the country-specific fracture risk assessment (FRAX) algorithm. INTRODUCTION: The aim of this study is to characterize the prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in healthy Hungarian men over 50 years of age. METHODS: We determined levels of 25-hydroxyvitamin D (25-OH-D), PTH, osteocalcin (OC), C-terminal telopeptides of type-I collagen (CTX-I), procollagen type 1 amino-terminal propeptide (PINP), BMD at L1-L4 (LS) and femur neck (FN), daily dietary calcium intake, and the 10-year probability of hip fracture and a major osteoporotic fracture using the country-specific FRAX algorithm in 206 randomly selected ambulatory men. RESULTS: The mean (range) age of the volunteers was 60 (51-81) years. The prevalence of hypovitaminosis D (25-OH-D, <75 nmol/L) was 52.9%. The mean (range) FRAX hip fracture and FRAX major osteoporotic fracture was 0.8% (0-9.4%) and 3.8% (1.7-16%), respectively. On comparing the vitamin D sufficient to the insufficient group, there was a statistically significant difference between the FRAX hip fracture and FRAX major osteoporotic fracture indexes. There was significant seasonal variation in the vitamin D levels; the lowest levels were measured in winter and the highest in summer. CONCLUSIONS: A high prevalence of hypovitaminosis D and low BMD were observed in the studied Hungarian male population. This is the first study reporting higher 10-year hip and major osteoporotic fracture probability using the country-specific FRAX algorithm in individuals with hypovitaminosis D.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Molekuláris Medicina
Megjelenés:	Osteoporosis International. - 24 : 1 (2013), p. 179-186. -
További szerzők:	Nagy E. Móré Csaba (1971-) (szülész-nőgyógyász) Kappelmayer János (1960-) (laboratóriumi szakorvos) Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos) Kalina Edit (1971-) (laboratóriumi analitikus) Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos)
Pályázati támogatás:	TÁMOP-4.2.1/B-09/1/KONV-2010-0007 TÁMOP Celluláris hematológia - immunológia
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001-es BibID:	BIBFORM068611
Első szerző:	Jakab Éva
Cím:	Standardizing 25-hydroxyvitamin D data from the HunMen cohort / E. Jakab, E. Kalina, Z. Petho, Z. Pap, A. Balogh, W. B. Grant, H. P. Bhattoa
Dátum:	2017
ISSN:	0937-941X
Megjegyzések:	Summary Standardization of 25-hydroxyvitamin D (25OHD)values is still a challenge.We propose standardization by correctionof the measured 25OHD values using the linear regressionbias from the National Institute of Standards andTechnology (NIST) ♭total' target values reported by VitaminD External Quality Assessment Scheme (DEQAS). Our approachcould perhaps be a practical solution to the anomalysurrounding non-standardized 25OHD values.Introduction Standardization of 25OHD values is still a challenge.We propose standardization by correction of the measured25OHD values using the linear regression equation derivedfrom the analysis of relationship between total 25OHDvalues measured by the methodology used by the laboratoryand the NIST total target values (TV) reported by the DEQASfor all 5 of the DEQAS samples in a given survey.Methods We applied our approach to standardize total25OHD values of the HunMen cohort.Results All 206 samples for the HunMen cohort were evaluatedusing the automated Liaison DiaSorin total 25OHDchemiluminescence immunoassay (CLIA). The timing ofthese measurements coincided with that of the October 2015DEQAS survey using samples 481 to 485. Following standardization,the mean total 25OHD changed from 53 to62 nmol/L and the prevalence of hypovitaminosis D(<75 nmol/L) decreased significantly from 84 to 72%.Conclusion A simple approach readily applicable at the routinediagnostic laboratory could perhaps be a practical solutionto the anomaly surrounding non-standardized 25OHD values
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk 25-Hydroxyvitamin D DEQAS HunMen Standardization
Megjelenés:	Osteoporosis International. - 28 : 5 (2017), p. 1653-1657. -
További szerzők:	Kalina Edit (1971-) (laboratóriumi analitikus) Pethő Zsófia (1981-) (reumatológus, immunológus) Pap Zoltán Domokos (1973-) Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos) Grant, William B. Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM059613
Első szerző:	Pethő Zsófia (reumatológus, immunológus)
Cím:	Vitamin D status in men with psoriatic arthritis : a case-control study / Z. Petho, E. Kulcsar-Jakab, E. Kalina, A. Balogh, A. Pusztai, K. Gulyas, A. Horvath, Z. Szekanecz, H. P. Bhattoa
Dátum:	2015
ISSN:	0937-941X
Megjegyzések:	Summary: We determined hypovitaminosis D prevalence inmen with psoriatic arthritis. This is a cross-sectional, analystblinded, age- and sex-matched, case-control study. Men withpsoriatic arthritis have significantly lower 25-hydroxyvitaminD levels. Men with psoriatic arthritis are at increased odds ofsuffering from hypovitaminosis D.Introduction: Skeletal manifestations as a result of abruptedbone metabolism may be predominant in psoriatic arthritis(PsA). Vitamin D plays a vital role in maintenance of skeletalhealth and is known to modulate the immune system in variousautoimmune diseases including PsA. The aim of the presentstudy was to determine the prevalence of hypovitaminosisD in a treatment naïve, de novo psoriatic arthritis male cohortin a cross-sectional, analyst blinded, age- and sex-matched,case-control study.Methods: 25 hydroxyvitamin D (25OHD), parathyroid (PTH),osteocalcin (OC) and C-terminal telopeptides of type-I collagen(CTx) levels, and lumbar spine and femoral neck bonemineral density were compared between 53 PsA and controls.Results: The prevalence of hypovitaminosis D (25hydroxyvitamin D (25OHD) levels <75 nmol/L) was 81 and57 % in the PsA and control groups, respectively. Comparedto the healthy controls, 25OHD (67.2 (12?137) nmol/L vs.51.9 (15?95) nmol/L; p=0.001) was significantly lower, andosteocalcin (13.6 (5?33) ?g/L vs. 18.2 (6?35) ?g/L; p=0.003)and C-terminal telopeptides of type-I collagen (0.20 (0.01?0.71) ?g/L vs. 0.28 (0.06?0.69) ?g/L; p=0.008) were significantlyhigher in the PsA group. A significant association wasfound between hypovitaminosis D and PsA; the odds for patientswith PsA of having hypovitaminosis D was 3.297 (95%confidence interval 1.372 to 7.922).Conclusion: The results of this study suggest that men withPsA have significantly lower 25-hydroxyvitamin D levels,and furthermore, men with PsA are at statistically significantincreased odds of suffering from hypovitaminosis D.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban bone markers bone mineral density men psoriatic arthritis vitamin D
Megjelenés:	Osteoporosis International. - 26 : 7 (2015), p. 1965-1970. -
További szerzők:	Jakab Éva (1969-) Kalina Edit (1971-) (laboratóriumi analitikus) Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos) Karancsiné Pusztai Anita (1989-) (tudományos segédmunkatárs) Gulyás Katalin (reumatológus) Horváth Ágnes (1985-) (reumatológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos)
Pályázati támogatás:	OTKA-105073 OTKA
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