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001-es BibID:	BIBFORM101778
035-os BibID:	(Scopus)85129340914 (Wos)000790205000001
Első szerző:	Kiss János (fizikus)
Cím:	3D printed anthropomorphic left ventricular myocardial phantom for nuclear medicine imaging applications / János Kiss, László Balkay, Kornel Kukuts, Marton Miko, Attila Forgacs, Gyorgy Trencsenyi, Aron K. Krizsan
Dátum:	2022
ISSN:	2197-7364
Megjegyzések:	Abstract Background: Anthropomorphic torso phantoms, including a cardiac insert, are frequently used to investigate the imaging performance of SPECT and PET systems. These phantom solutions are generally featuring a simple anatomical representation of the heart. 3D printing technology paves the way to create cardiac phantoms with more complex volume defnition. This study aimed to describe how a fllable left ventricular myocardium (LVm) phantom can be manufactured using geometry extracted from a patient image. Methods: The LVm of a healthy subject was segmented from 18F-FDG attenuation corrected PET image set. Two types of phantoms were created and 3D printed using polyethylene terephthalate glycol (PETG) material: one representing the original healthy LVm, and the other mimicking myocardium with a perfusion defect. The accuracy of the LVm phantom production was investigated by high-resolution CT scanning of 3 identical replicas. 99mTc SPECT acquisitions using local cardiac protocol were performed, without additional scattering media ("in air" measurements) for both phantom types. Furthermore, the healthy LVm phantom was inserted in the commercially available DataSpectrum Anthropomorphic Torso Phantom ("in torso" measurement) and measured with hot background and hot liver insert. Results: Phantoms were easy to fll without any air-bubbles or leakage, were found to be reproducible and fully compatible with the torso phantom. Seventeen segments polar map analysis of the "in air" measurements revealed that a signifcant defcit in the distribution appeared where it was expected. 59% of polar map segments had less than 5% deviation for the "in torso" and "in air" measurement comparison. Excluding the defcit area, neither comparison had more than a 12.4% deviation. All the three polar maps showed similar apex and apical region values for all confgurations. Conclusions: Fillable anthropomorphic 3D printed phantom of LVm can be produced with high precision and reproducibility. The 3D printed LVm phantoms were found to be suitable for SPECT image quality tests during diferent imaging scenarios. The fexibility of the 3D printing process presented in this study provides scalable and anthropomorphic image quality phantoms in nuclear cardiology imaging.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk 3D nyomtatás SPECT Kardiológia Tc-99m Fantom
Megjelenés:	EJNMMI Physics. - 9 : 1 (2022), p. 34. -
További szerzők:	Balkay László (1963-) (biofizikus) Kukuts Kornél Mikó Márton (1990-) Forgács Attila (1985-) (fizikus) Trencsényi György (1978-) (biológus, biokémikus, molekuláris biológus) Krizsán Áron Krisztián (1986-) (fizikus)
Pályázati támogatás:	TKP2020-NKA-04 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM087279
035-os BibID:	(WoS)000492444401187
Első szerző:	Mikó Márton
Cím:	Alterations of peripherial micorcirculation in Diabetes mellitus and Obesity / M. Mikó, J. Varga, F. Nagy, M. Emri, M. Káplár, A. Forgács, I. Garai
Dátum:	2019
ISSN:	1619-7070 1619-7089
Megjegyzések:	Aim/Introduction: The number of people with obesity and diabetes is continously growing. These are important metabolic drivers of cerebrovascular and cardiovascular diseases as well as peripheral neuropathy. Damage to the microcirculation is the basis for these conditions.In our study we investigated peripheral perfusion in these two metabolic diseases and its correlation with laboratory parameters and neuropathy. Materials and Methods: In this prospective study, 57 patients with controlled type 2 diabetes mellitus (T2DM) (mean age:52?9.6) and 46 patients with obesity (50.6?7.9) were recruited. BMI was 34.1?5.9 in T2DM and 38.1?6.1 in the obese group. Quantitative Tc99m HMPAO (Mediradiopharma, Hungary) SPECT/CT (AnyscanFlexSC, Mediso, Hungary) studies were performed to assess peripheral microcirculation in the legs. Patients with known symptomatic peripheral circulation abnormalities were excluded from the study. For the SUVmean calculation, fixed sized spheric VOIs (volume of interest) were drawn in the calf musculature bilaterally. Neurometer testing (NM-01/CPT) was used for evaluating sub-clinical peripheral nerve dysfunction. For statistical analysis, Shapiro normality test, Wilcoxon test and paired Spearman correlation was done. Results: There were no significant differences of calculated SUVmean values in right and left legs in both groups, neither were there any in neurometer testing. However, leg perfusion was significantly lower in the diabetic group predominantly on the left side (p=0.015 right leg, p=0,00065 left leg). Neurometer data showed correlation with HBA1C in the diabetic group, but none with leg perfusion. There was no correlation between neurometer test results and leg perfusion in the obese group. We also investigated the correlation of BMI, age and leg perfusion. BMI showed positive correlation with mean leg perfusion (rho=0,36, p=0,001) and no correlation with age was found. Conclusion: Quantitative leg perfusion SPECT/CT with Tc99m HMPAO is a sensitive method for evaluating subclinical perfusion abnormalities, providing complementary information for early assessment of peripheral neuropathy in diabetes. Further investigation is needed to understand the background of correlation of leg perfusion and BMI. References: None
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt folyóiratcikk
Megjelenés:	European Journal of Nuclear Medicine and Molecular Imaging. - 46 : S1 (2019), p. S204-S205. -
További szerzők:	Varga József (1955-) (fizikus) Nagy Ferenc (1984-) (fizikus) Emri Miklós (1962-) (fizikus) Káplár Miklós (1965-) (belgyógyász, diabetológus) Forgács Attila (1985-) (fizikus) Garai Ildikó (1966-) (radiológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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