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001-es BibID:	BIBFORM072627
035-os BibID:	(cikkazonosító)771 (scopus)85043576366 (wos)000428309800128
Első szerző:	Kiss Rita (laboratóriumi diagnosztika szakorvos)
Cím:	Insulin-Sensitizer Effects of Fenugreek Seeds in Parallel with Changes in Plasma MCH Levels in Healthy Volunteers / Kiss Rita, Szabó Katalin, Gesztelyi Rudolf, Somodi Sándor, Kovács Péter, Szabó Zoltán, Németh József, Priksz Dániel, Kurucz Andrea, Juhász Béla, Szilvássy Zoltán
Dátum:	2018
ISSN:	1661-6596 1422-0067
Megjegyzések:	In developed, developing and low-income countries alike, type 2 diabetes mellitus (T2DM)is one of the most common chronic diseases, the severity of which is substantially a consequenceof multiple organ complications that occur due to long-term progression of the disease beforediagnosis and treatment. Despite enormous investment into the characterization of the disease, itslong-term management remains problematic, with those afflicted enduring significant degradationin quality-of-life. Current research efforts into the etiology and pathogenesis of T2DM, are focusedon defining aberrations in cellular physiology that result in development of insulin resistance andstrategies for increasing insulin sensitivity, along with downstream effects on T2DM pathogenesis.Ongoing use of plant-derived naturally occurring materials to delay the onset of the disease oralleviate symptoms is viewed by clinicians as particularly desirable due to well-established efficacyand minimal toxicity of such preparations, along with generally lower per-patient costs, in comparisonto many modern pharmaceuticals. A particularly attractive candidate in this respect, is fenugreek,a plant that has been used as a flavouring in human diet through recorded history. The presentstudy assessed the insulin-sensitizing effect of fenugreek seeds in a cohort of human volunteers, andtested a hypothesis that melanin-concentrating hormone (MCH) acts as a critical determinant ofthis effect. A test of the hypothesis was undertaken using a hyperinsulinemic euglycemic glucoseclamp approach to assess insulin sensitivity in response to oral administration of a fenugreek seedpreparation to healthy subjects. Outcomes of these evaluations demonstrated significant improvementin glucose tolerance, especially in patients with impaired glucose responses. Outcome data furthersuggested that fenugreek seed intake-mediated improvement in insulin sensitivity correlated withreduction in MCH levels.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk hyperinsulinemic euglycemic glucose clamp (HEGC) fenugreek melanin-concentrating hormone (MCH) RIA type 2 diabetes clinical pilot study
Megjelenés:	International Journal Of Molecular Sciences. - 19 : 3 (2018), p. 1-17. -
További szerzők:	Szabó Katalin (1989-) (táplálkozástudományi szakember) Gesztelyi Rudolf (1969-) (kísérletes farmakológus) Somodi Sándor (1977-) (belgyógyász) Kovács Péter (1947-) (belgyógyász, kardiológus, klinikai farmakológus) Szabó Zoltán (1973-) (belgyógyász, kardiológus) Németh József (1954-) (vegyész, analitikus) Priksz Dániel (1989-) (farmakológus) Kurucz Andrea (1984-) (orvos) Juhász Béla (1978-) (kísérletes farmakológus) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus)
Pályázati támogatás:	GINOP-2.3.4-15-2016-00002 GINOP AGR-PIAC-13-1-2013-0008 Egyéb
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001-es BibID:	BIBFORM108875
035-os BibID:	(cikkazonosító)4115 (Scopus)85149053802 (WoS)000945033100001
Első szerző:	Lőrincz Hajnalka (biológus)
Cím:	Impaired Organokine Regulation in Non-Diabetic Obese Subjects : halfway to the Cardiometabolic Danger Zone / Hajnalka Lőrincz, Balázs Ratku, Sára Csiha, Ildikó Seres, Zoltán Szabó, György Paragh, Mariann Harangi, Sándor Somodi
Dátum:	2023
ISSN:	1422-0067
Megjegyzések:	Altered organokine expression contributes to increased cardiometabolic risk in obesity. Our aim was to evaluate the associations of serum afamin with glucose homeostasis, atherogenic dyslipidemia, and other adipokines in severe obesity to clarify the early metabolic alterations. 106 non diabetic obese (NDO) subjects and 62 obese patients with type 2 diabetes matched for age, gender, and body mass index (BMI) were enrolled in this study. We compared their data with 49 healthy, lean controls. Serum afamin and retinol-binding protein 4 (RBP4), as well as plasma plasminogen activator inhibitor-1 (PAI-1), were measured with ELISA, and lipoprotein subfractions were analyzed using Lipoprint gel electrophoresis. Afamin and PAI-1 found to be significantly higher in the NDO and T2M group (p < 0.001 and p < 0.001, respectively) than in the controls. In contrast, RBP4 was unexpectedly lower in the NDO and T2DM group compared to controls (p < 0.001). Afamin showed negative correlations with mean LDL size and RBP4, but positive correlations with anthropometric, glucose/lipid parameters, and PAI-1 in both the overall patients and the in NDO + T2DM groups. BMI, glucose, intermediate HDL, and small HDL were predictors of afamin. Afamin may serve as a biomarker for the severity of cardiometabolic disturbances in obesity. The complexity of organokine patterns in NDO subjects draws attention to the diverse spectrum of obesity-related comorbidities.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk obesity type 2 diabetes insulin resistance afamin plasminogen-activator inhibitor-1 retinol binding protein 4 lipid metabolism lipoprotein subfraction cardiometabolic
Megjelenés:	International Journal Of Molecular Sciences. - 24 : 4 (2023), p. 1-13. -
További szerzők:	Ratku Balázs (1985-) (mentőtiszt) Csiha Sára (1985-) (Biológus) Seres Ildikó (1954-) (biokémikus) Szabó Zoltán (1973-) (belgyógyász, kardiológus) Paragh György (1953-) (belgyógyász) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Somodi Sándor (1977-) (belgyógyász)
Pályázati támogatás:	PD124126 OTKA K142273 OTKA
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