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001-es BibID:BIBFORM070833
Első szerző:Den Heijer, Casper D. J.
Cím:Prevalence and resistance of commensal Staphylococcus aureus, including meticillin-resistant S aureus, in nine European countries : a cross-sectional study / Casper D. J. den Heijer, Evelien M. E. van Bijnen, W. John Paget, Mike Pringle, Herman Goossens, Cathrien A. Bruggeman, François G. Schellevis, Ellen E. Stobberingh, the APRES Study Team
Dátum:2013
ISSN:1473-3099
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Lancet Infectious Diseases. - 13 : 5 (2013), p. 409-415. -
További szerzők:Van Bijnen, Evelien M. E. Paget, W. John Pringle, Mike Goossens, Herman Bruggeman, Cathrien A. Schellevis, Francois G. Stobberingh, Ellen E. Kolozsvári László Róbert (1977-) (háziorvos) The APRES Study Team
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2.

001-es BibID:BIBFORM077691
035-os BibID:(cikkazonosító)253
Első szerző:Kolozsvári László Róbert (háziorvos)
Cím:Patient-related factors, antibiotic prescribing and antimicrobial resistance of the commensal Staphylococcus aureus and Streptococcus pneumoniae in a healthy population - Hungarian results of the APRES study / László Róbert Kolozsvári, József Kónya, John Paget, Francois G. Schellevis, János Sándor, Gergő József Szőllősi, Szilvia Harsányi, Zoltán Jancsó, Imre Rurik
Dátum:2019
ISSN:1471-2334
Megjegyzések:Background: Antimicrobial resistance (AMR) is an increasing public health problem worldwide. We studied some patient-related factors that might influence the antimicrobial resistance. and whether the volume of antibiotic prescribing of the primary care physicians correlate with the antibiotic resistance rates of commensal nasal Staphylococcus aureus and Streptococcus pneumoniae. Methods: The socio-demographic questionnaires, the antibiotic prescription and resistance data of commensal nasal S. aureus and S. pneumoniae were collected in the 20 participating Hungarian practices of the APRES study. Multivariate logistic regression analyses were performed on the patient-related data and the antimicrobial resistance of the S. aureus and S. pneumoniae on individual, patient level. Ecological analyses were performed with Spearman's rank correlations at practice level, the analyses were performed in the whole sample (all practices) and in the cohorts of primary care practices taking care of adults (adult practices) or children (paediatric practices). Results: According to the multivariate model, age of the patients significantly influenced the antimicrobial resistance of the S. aureus (OR = 0.42, p = 0.004) and S. pneumoniae (OR = 0.89, p < 0.001). Living with children significantly increased the AMR of the S. pneumoniae (OR = 1.23, p = 0.019). In the cohorts of adult or paediatric practices, neither the age nor other variables influenced the AMR of the S. aureus and S. pneumoniae. At practice level, the prescribed volume of penicillins significantly correlated with the resistance rates of the S. aureus isolates to penicillin (rho = 0.57, p = 0.008). The volume of prescribed macrolides, lincosamides showed positive significant correlations with the S. pneumoniae resistance rates to clarithromycin and/or clindamycin in all practices (rho = 0.76, p = 0.001) and in the adult practices (rho = 0.63, p = 0.021). Conclusions: The age is an important influencing factor of antimicrobial resistance. The results also suggest that there may be an association between the antibiotic prescribing of the primary care providers and the antibiotic resistance of the commensal S. aureus and S. pneumoniae. The role of the primary care physicians in the appropriate antibiotic prescribing is very important to avoid the antibiotic resistance.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Antimicrobial resistance
Antibacterial resistance
Commensal
Healthy population
Patient-related factors
Staphylococcus aureus
Streptococcus pneumoniae
Megjelenés:BMC Infectious Diseases. - 19 (2019), p. 1-8. -
További szerzők:Kónya József (1964-) (szakorvos, klinikai mikrobiológus) Paget, John Schellevis, Francois G. Sándor János (1966-) (orvos-epidemiológus) Szőllősi Gergő József (1991-) (népegészségügyi ellenőr, népegészségügyi szakember) Kolozsváriné Harsányi Szilvia (1983-) (okleveles egészségpolitikai szakértő) Jancsó Zoltán (1973-) (orvos, háziorvos szakorvos, foglalkozás-orvostan szakorvos) Rurik Imre (1953-) (háziorvos, foglalkozás-egészségügyi szakorvos, urológus)
Pályázati támogatás:223083
FP7
Internet cím:DOI
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3.

001-es BibID:BIBFORM075033
Első szerző:Van Bijnen, Evelien M. E.
Cím:Primary care treatment guidelines for skin infections in Europe : congruence with antimicrobial resistance found in commensal Staphylococcus aureusin the community / Evelien M. E. van Bijnen, W. John Paget, Casper D. J. den Heijer, Ellen E. Stobberingh, Cathrien A. Bruggeman, François G. Schellevis, the APRES Study Team
Dátum:2014
ISSN:1471-2296
Megjegyzések:BackgroundOver 90% of antibiotics for human use in Europe are prescribed in primary care. We assessed the congruence between primary care treatment guidelines for skin infections and commensal Staphylococcus aureus (S. aureus) antimicrobial resistance levels in community-dwelling persons.MethodsThe prevalence of antimicrobial resistance in S. aureus was analysed by taking nose swabs from healthy primary care patients in nine European countries (total N = 32,032). Primary care treatment guidelines for bacterial skin infections were interpreted with respect to these antimicrobial resistance patterns. First- and second-choice recommendations were assessed and considered congruent if resistance to the antibiotic did not exceed 20%.ResultsWe included primary care treatment guidelines for impetigo, cellulitis, folliculitis and furuncle. Treatment recommendations in all countries were consistent: most of the first-choice recommendations were beta-lactams, both for children and adults. Antimicrobial resistance levels were low, except for penicillin (on average 73% resistance). Considerable variation in antimicrobial resistance levels was found between countries, with Sweden displaying the lowest levels and Spain the highest. In some countries resistance to penicillin and azithromycin was significantly higher in children (4-17 years) compared with adults.ConclusionsMost of the first- and second-choice recommendations in the treatment guidelines for skin infections were congruent with commensal S. aureus antimicrobial resistance patterns in the community, except for two recommendations for penicillin. Given the variation in antimicrobial resistance levels between countries, age groups and health care settings, national data regarding antimicrobial resistance in the community should be taken into account when updating or developing primary care treatment guidelines.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Antibiotic resistance
Treatment guidelines
Primary care
Skin infections
Megjelenés:BMC Family Practice. - 15 : 1 (2014), p. 175. -
További szerzők:Paget, W. John Den Heijer, Casper D. J. Stobberingh, Ellen E. Bruggeman, Cathrien A. Schellevis, Francois G. Kolozsvári László Róbert (1977-) (háziorvos) The APRES Study Team
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4.

001-es BibID:BIBFORM070823
Első szerző:Van Bijnen, Evelien M. E.
Cím:Antibiotic Exposure and Other Risk Factors for Antimicrobial Resistance in Nasal Commensal Staphylococcus aureus : an Ecological Study in 8 European Countries / Evelien M. E. van Bijnen, John Paget, Elly S. M. de Lange-de Klerk, Casper D. J. den Heijer, Ann Versporten, Ellen E. Stobberingh, Herman Goossens, François G. Schellevis, the APRES Study Team
Dátum:2015
ISSN:1932-6203
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Plos One. - 10 : 8 (2015), p. 1-11. -
További szerzők:Paget, John De Lange-de Klerk, Elly S. M. Den Heijer, Casper D. J. Versporten, Ann Stobberingh, Ellen E. Goossens, Herman Schellevis, Francois G. Kolozsvári László Róbert (1977-) (háziorvos) The APRES Study Team
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