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001-es BibID:BIBFORM101701
035-os BibID:(cikkazonosító)6251232 (WOS)000802856500004 (Scopus)85130364595
Első szerző:Szabó Katalin (orvos)
Cím:Clinical, Serological, and Genetic Characteristics of a Hungarian Myositis-Scleroderma Overlap Cohort / Szabó Katalin, Bodoki Levente, Nagy-Vincze Melinda, Béldi Tibor, Vincze Anett, Zilahi Erika, Varga József, Szűcs Gabriella, Dankó Katalin, Griger Zoltán
Dátum:2022
ISSN:2314-6133 2314-6141
Megjegyzések:Overlap myositis is a distinct subgroup of idiopathic inflammatory myositis (IIM) with various clinical phenotypes. The aim of this study was to determine the clinical, serological, and genetic features of systemic sclerosis (SSc)-IIM overlap patients. It was a retrospective study using clinical database of 39 patients, fulfilling both the criteria of SSc and IIM. 56.4% of the patients had limited cutaneous, 43.6% had diffuse cutaneous SSc, whereas 7.7% of the patients had dermatomyositis and 92.3% polymyositis. The two diseases occurred simultaneously in 58.97%, while 10.26% in myositis and 30.77% in scleroderma were initially diagnosed. The frequencies of organ involvement were interstitial lung disease 71.8%, dysphagia 66.7%, cardiac involvement 41%, pulmonary arterial hypertension (PAH) 30.8%, and renal involvement 12.8%, respectively. The presence of human leukocyte antigen eth HLA THORN - DRB1 * 03 and DQA1 * 051 * 01 alleles were significantly higher in the overlap patients than in healthy controls (82.35% vs. 27.54%; p < 0.0001 and 88.24% vs. 30.16; p < 0.0001). Certain clinical parameters, such as fever at diagnosis (41.67% vs. 7.41%, p = 0.0046), cardiac involvement (83.33% vs. 22.22%, p = 0.0008), subcutaneous calcinosis (41.66 vs. 11.11, p = 0.01146), and claw hand deformity (25% vs. 11.11%, p = 0.00016) were significantly associated with the presence of PAH. Upon comparison, the overlap patients and anti-Jo-1 positive antisynthetase patients showed similarities in terms of genetic results and major clinical features; however, SSc-IIM overlap patients could be distinguished with higher erythrocyte sedimentation rate (ESR) level, more frequent presence of Raynaud's phenomenon (p < 0.0001; OR: 20.00), dysphagia (p < 0.0001; OR: 15.63), and infrequent livedo reticularis (p < 0.01; OR: 0.11). SSc-IIM overlap myositis is a unique group within IIM-s possessing characteristic clinical features.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Biomed Research International. - 2022 (2022), p. 1-9. -
További szerzők:Bodoki Levente (1986-) (PhD hallgató) Nagy-Vincze Melinda (1985-) (orvos) Béldi Tibor (1994-) (orvos) Vincze Anett (1993-) Zilahi Erika (1964-) (molekuláris biológus) Varga József (1955-) (fizikus) Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus)
Pályázati támogatás:EFOP-3.6.3-VEKOP-16-2017-00009
EFOP
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2.

001-es BibID:BIBFORM076065
035-os BibID:(cikkazonosító)6416378 (WOS)000449223800001 (Scopus)85056239957
Első szerző:Szabó Katalin (orvos)
Cím:Effect of Genetic and Laboratory Findings on Clinical Course of Antisynthetase Syndrome in a Hungarian Cohort / Szabó Katalin, Bodoki Levente, Nagy-Vincze Melinda, Vincze Anett, Zilahi Erika, Szodoray Peter, Dankó Katalin, Griger Zoltán
Dátum:2018
ISSN:2314-6133 2314-6141
Megjegyzések:The aim of this study was to determine the clinical, serological, and genetic features of anti-Jo-1 positive antisynthetase patients followed by a Hungarian single centre to identify prognostic markers, which can predict disease phenotypes and disease progression. It was a retrospective study using clinical database of 49 anti-Jo-1 positive patients. 100% of patients exhibited myositis, 73% interstitial lung disease, 88% arthritis, 65% Raynaud's phenomenon, 43% fever, 33% mechanic's hand, and 12% dysphagia. We could detect significant correlation between anti-Jo-1 titer and the CK and CRP levels at disease onset and during disease course. HLA DRB1*03 positivity was present in 68.96% of patients, where the CK level at diagnosis was significantly lower compared to the HLA DRB1*03 negative patients. HLA DQA1*0501-DQB1*0201 haplotype was found in 58.62% of patients, but no significant correlation was found regarding any clinical or laboratory features. Higher CRP, ESR level, RF positivity, and the presence of fever or vasculitic skin lesions at the time of diagnosis indicated a higher steroid demand and the administration of higher number of immunosuppressants during the follow-up within anti-Jo-1 positive patients. The organ involvement of the disease was not different in HLA-DRB1*0301 positive or negative patients who were positive to the anti-Jo-1 antibody; however, initial CK level was lower in HLA-DRB1*0301 positive patients. Distinct laboratory and clinical parameters at diagnosis could be considered as prognostic markers.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
anti-Jo-1
antisynthetase syndrome
Megjelenés:Biomed Research International. - 2018 (2018), p. 1-9. -
További szerzők:Bodoki Levente (1986-) (PhD hallgató) Nagy-Vincze Melinda (1985-) (orvos) Vincze Anett (1993-) Zilahi Erika (1964-) (molekuláris biológus) Szodoray Péter (1973-) (belgyógyász, orvos) Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus)
Pályázati támogatás:Debreceni Egyetem ÁOK Research Fund (Bridging Fund 2015, No. 1G3DBLB0MU10 247)
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3.

001-es BibID:BIBFORM086958
035-os BibID:(WoS)000548924800004 (Scopus)85087474643 (PubMed)32616032 (cikkazonosító)426
Első szerző:Vincze Anett
Cím:The risk of fracture and prevalence of osteoporosis is elevated in patients with idiopathic inflammatory myopathies : cross-sectional study from a single Hungarian center / Anett Vincze, Levente Bodoki, Katalin Szabó, Melinda Nagy-Vincze, Orsolya Szalmás, József Varga, Katalin Dankó, János Gaál, Zoltán Griger
Dátum:2020
ISSN:1471-2474
Megjegyzések:Background: The prevalence of osteoporosis and risk of fractures is elevated in rheumatoid arthritis (RA), but we have limited information about the bone mineral density (BMD) and fracture risk in patients with inflammatory myopathies. We intended to ascertain and compare fracture risk, bone mineral density and the prevalence of vertebral fractures in patients with inflammatory myositis and rheumatoid arthritis and to assess the effect of prevalent fractures on the quality of life and functional capacity. Methods: Fifty-two patients with myositis and 43 patients with rheumatoid arthritis were included in the study. Fracture Risk was determined using FRAX? Calculation Tool developed by the University of Sheffield. Dual energy X-ray absorptiometry and bidirectional thoracolumbar radiographs were performed to assess BMD and vertebral fractures. Quality of life was measured with Short Form-36 (SF-36) and physical function assessment was performed using Health Assessment Questionnaire (HAQ). Results: We found a significantly elevated fracture risk in RA as compared to myositis patients if the risk assessment was performed without the inclusion of the BMD results. If BMD results and glucocorticoid dose adjustment were taken into account, the differences in fracture risk were no longer significant. The prevalence of osteoporosis was found to be significantly higher in the myositis group (7% vs. 13.5%, p: 0.045), but the fracture prevalence was similar in the two groups (75% vs. 68%). The fracture rates were independently associated with age in the myositis group, and with lower BMD results in the RA patients. The number of prevalent fractures was significantly correlated to poorer physical function in both groups, and poorer health status in the myositis group, but not in the RA group. Conclusions: Our findings suggest that inflammatory myopathies carry significantly elevated risks for osteoporosis and fractures. These higher risks are comparable to ones detected with RA in studies and strongly affect the physical function and quality of life of patients. Therefore further efforts are required to make the fracture risk assessment reliable and to facilitate the use of early preventive treatments.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Fracture risk
Myositis
Rheumatoid arthritis
Vertebral fractures
Megjelenés:Bmc Musculoskeletal Disorders. - 21 : 1 (2020), p. 1-8. -
További szerzők:Bodoki Levente (1986-) (PhD hallgató) Szabó Katalin (1991-) (orvos) Nagy-Vincze Melinda (1985-) (orvos) Szalmás Orsolya Varga József (1955-) (fizikus) Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus) Gaál János (1965-) (reumatológus, belgyógyász) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus)
Pályázati támogatás:Új Nemzeti Kiválóság Program ÚNKP-17-2
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