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001-es BibID:	BIBFORM071709
035-os BibID:	(cikkazonosító)e12470
Első szerző:	Katkó Mónika (biológus)
Cím:	Thyroglobulin level at week 16 of pregnancy is superior to urinary iodine concentration in revealing preconceptual and first trimester iodine supply / Katko Monika, Gazso Andrea Anett, Hircsu Ildiko, Bhattoa Harjit Pal, Molnar Zsuzsanna, Kovacs Bela, Andrasi David, Aranyosi Janos, Makai Rita, Veress Lajos, Torok Olga, Bodor Miklos, Samson Laszlo, Nagy Endre V.
Dátum:	2018
ISSN:	1740-8695
Megjegyzések:	Pregnant women are prone to iodine deficiency due to the increased need for iodine during gestation.Progress has recently occurred in establishing serum thyroglobulin (Tg) as an iodine statusbiomarker, but there is no accepted reference range for iodine sufficiency during pregnancy. Anobservational study was conducted in 164 pregnant women. At week 16 of gestation urinaryiodine concentration (UIC), serum Tg, and thyroid functions were measured, and information onthe type of iodine supplementation and smoking were recorded. The parameters of those whostarted iodine supplementation (?150 ?g/day) at least 4 weeks before pregnancy (n = 27), whostarted at the detection of pregnancy (n = 51), and who had no iodine supplementation (n = 74)were compared. Sufficient iodine supply was found in the studied population based on medianUIC (162 ?g/L). Iodine supplementation ?150 ?g/day resulted in higher median UIC regardlessof its duration (nonusers: 130 ?g/L vs. prepregnancy iodine starters: 240 ?g/L, and pregnancyiodine starters: 205 ?g/L, p < .001, and p = .023, respectively). Median Tg value of pregnancystarters was identical to that of nonusers (14.5 vs. 14.6 ?g/L), whereas prepregnancy startershad lower medianTg (9.1 ?g/L, p = .018). SerumTg concentration at week 16 of pregnancy showednegative relationship (p = .010) with duration of iodine supplementation and positive relationship(p = .008) with smoking, a known interfering factor of iodine metabolism, by multiple regressionanalysis. Serum Tg at week 16 of pregnancy may be a promising biomarker of preconceptual andfirst trimester maternal iodine status, the critical early phase of foetal brain development.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban iodine status thyroid pregnancy thyroglobulin
Megjelenés:	Maternal And Child Nutrition. - 14 : 1 (2018), p. 1-9. -
További szerzők:	Gazsó Andrea Hircsu Ildikó Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Molnár Zsuzsanna (1980-) (szülész-nőgyógyász, labor szakorvosjelölt, urológus) Kovács Béla (1963-) (okleveles vegyész, angol szakfordító) Andrási Dávid (1984-) (vegyész) Aranyosi János (1963-) (szülész-nőgyógyász) ifj. Makai Rita Veress Lajos (1950-) (vegyész) Török Olga (1956-) (szülész-nőgyógyász, humángenetikus) Bodor Miklós (1969-) (belgyógyász, endokrinológus) Sámson László Nagy Endre V. (1957-) (belgyógyász, endokrinológus)
Pályázati támogatás:	TÁMOP-4.2.2.A-11/1/KONV-2012-0031 TÁMOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM053793
Első szerző:	Molnár Zsuzsanna (szülész-nőgyógyász, labor szakorvosjelölt, urológus)
Cím:	Fertility of testicular cancer patients after anticancer treatment : experience of 11 years / Z. Molnár, E. Berta, M. Benyó, R. Póka, Z. Kassai, T. Flaskó, A. Jakab, M. Bodor
Dátum:	2014
ISSN:	0031-7144
Megjegyzések:	Testicular cancer affects men mostly in their reproductive age with a cure rate over 90%. Preserved fertilityis one of the main concerns of the survivors. To further elucidate the question of fertility after anticancertreatment for testicular cancer, we performed a survey among patients who underwent spermcryopreservationprocedure in our department. A structured questionnaire was designed to collect data on demography,anticancer treatment, histological type of cancer, family planning intentions and fertility prior to and aftertreatment. During a period of 11 years 86 men underwent semen cryopreservation before starting chemoorradiotherapy. Fifty-nine of them consented to participate in the study. The average length of follow upwas 4.6?3.8 years. In case of 11.9% of the patients their banked sperm was used, which led to live birthin 57% of the couples. The partners of 6 patients became pregnant after in vitro fertilization (IVF) resultingin 4 live births and 2 miscarriages. The spontaneous pregnancy rate was 22%. Spontaneous pregnancyoccurred in 13 partners resulting in 18 pregnancies followed by 12 live births, 2 artificial abortions and 4miscarriages. We could not prove any association between preserved fertility and anticancer treatment orthe histological type of the cancer. In conclusion, although spontaneous pregnancy rate is remarkably highafter anticancer treatment for testicular cancer, the risk of infertility after receiving gonadotoxic treatmentcannot be predicted. Cryopreservation is a safe and effective method to preserve fertility in these cases.As a result we strongly recommend discussing the advantages of semen cryopreservation with all patientsawaiting treatment for testicular cancer.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Pharmazie 69 : 6 (2014), p. 437-441. -
További szerzők:	Berta Eszter (1980-) (belgyógyász) Benyó Mátyás (1982-) (urológus) Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus) Bazsáné Kassai Zsuzsa (1946-) (embriológus) Flaskó Tibor (1960-) (urológus) Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus) Bodor Miklós (1969-) (belgyógyász, endokrinológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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