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001-es BibID:BIBFORM107307
035-os BibID:(cikkazonosító)295 (scopus)85138648829 (wos)000857586100001
Első szerző:Nasr, Nayla Mohamed Gomaa
Cím:Prognostic Modelling Studies of Coronary Heart Disease : A Systematic Review of Conventional and Genetic Risk Factor Studies / Nasr Nayla, Soltész Beáta, Sándor János, Adány Róza, Fiatal Szilvia
Dátum:2022
ISSN:2308-3425
Megjegyzések:This study aims to provide an overview of multivariable prognostic modelling studies developed for coronary heart disease (CHD) in the general population and to explore the optimal prognostic model by comparing the models' performance. A systematic review was performed using Embase, PubMed, Cochrane, Web of Science, and Scopus databases until 30 November 2019. In this work, only prognostic studies describing conventional risk factors alone or a combination of conventional and genomic risk factors, being developmental and/or validation prognostic studies of a multivariable model, were included. A total of 4021 records were screened by titles and abstracts, and 72 articles were eligible. All the relevant studies were checked by comparing the discrimination, reclassification, and calibration measures. Most of the models were developed in the United States and Canada and targeted the general population. The models included a set of similar predictors, such as age, sex, smoking, cholesterol level, blood pressure, BMI, and diabetes mellitus. In this study, many articles were identified and screened for consistency and reliability using CHARM and GRIPS statements. However, the usefulness of most prognostic models was not demonstrated; only a limited number of these models supported clinical evidence. Unfortunately, substantial heterogeneity was recognized in the definition and outcome of CHD events. The inclusion of genetic risk scores in addition to conventional risk factors might help in predicting the incidence of CHDs; however, the generalizability of the existing prognostic models remains open. Validation studies for the existing developmental models are needed to ensure generalizability, improve the research quality, and increase the transparency of the study.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
systematic review
coronary heart disease
prognostic models
genetic risk factors
conventional risk factors
Megjelenés:Journal of Cardiovascular Development and Disease. - 9 : 9 (2022), p. 1-21. -
További szerzők:Soltész Beáta (1987-) (molekuláris biológus) Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
GINOP
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2.

001-es BibID:BIBFORM105973
Első szerző:Soltész Beáta (molekuláris biológus)
Cím:Representation of hypertension related polymorphisms in the Hungarian general and Roma populations / B. Soltész, Sz. Fiatal, Zs. Kósa, J. Sándor, R. Ádány
Dátum:2016
ISSN:1101-1262
Megjegyzések:Background Roma represents the largest minority population in Europe. It was recently pointed out that the prevalence of hypertension is lower among the Roma compared to the majority population ever tested. Concerning the fact that hypertension is known to be highly affected by inheritable factors, our aim was to identify whether genetic factors contribute to the lower prevalence of hypertension. Methods SNPs (N = 23) related to renin-angiotensin-aldosterone system (AGT, CYP11, AGTR1, ACE), regulation of vascular tone (NOS3) and renal tubular sodium reabsorption (ADD1, NPPA), and homocysteine metabolism (MTHFR) previously described to be closely related to hypertension were investigated in representative random samples of the Hungarian Roma and general populations (N = 1202, N = 1167, respectively). Differences in allele frequencies, as well as genetic risk scores both unweighted (GRS) and weighted (wGRS) were defined for the study groups compared to estimate the joint effect of SNPs. 9th European Public Health Conference: Parallel Sessions 215 Downloaded from https://academic.oup.com/eurpub/article/26/suppl_1/ckw170.025/2448813 by School of Public Health user on 13 December 2022 Results Differences in allele frequencies between the study populations were significant in case of 7 polymorphisms after multiple test correction, and almost all susceptible alleles were more prevalent in the general population. The mean of GRSs was 19.6 3.1 SD in the Roma population while it was 20.4 3.2 SD in the general group (p < 0.01). Twenty-four % of Roma subject were in the bottom fifth of the GRS (GRS 17) compared with 18% of those in the general population while only 9% of Roma people were in the top fifth (GRS 24) of the GRS compared with 17% of those in the general population (p < 0.001). In addition, the mean wGRS was significantly lower in the subjects of Roma population comparing to the subjects of general population (0.5 vs. 0.6, p < 0.01). Conclusions GRS modelling showed lower burden of risk alleles for hypertension in Roma compared to Hungarian general population, suggesting ethnicity-related differences in genetic architecture underlying lower hypertension prevalence among Roma.
Tárgyszavak:Orvostudományok Egészségtudományok konferenciacikk
folyóiratcikk
Megjelenés:European Journal Of Public Health. - 26 : suppl1 (2016), p. 215-216. -
További szerzők:Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
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