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001-es BibID:	BIBFORM083072
Első szerző:	Csikai Enikő
Cím:	Influence of angiotensin-converting enzyme inhibition on reversibility of alterations in arterial wall and cognitive performance associated with early hypertension : a follow-up study / Csikai Enikő, Andrejkovics Mónika, Balajthy-Hidegh Bernadett, Hofgárt Gergely, Kardos László, Diószegi Ágnes, Rostás Róbert, Czuriga-Kovács Katalin Réka, Csongrádi Éva, Csiba László
Dátum:	2019
ISSN:	0025-7974
Megjegyzések:	The importance of optimal blood pressure control for preventing or reducing the impairment of vascular and cognitive functions is well known. However, the reversibility of early alterations in vascular and cognitive functions through antihypertensive agents is under-investigated. In this study, we evaluated the influence of 3 months of angiotensin-converting enzyme (ACE) inhibition treatment on the morphological and functional arterial wall and cognitive performance changes in 30 newly diagnosed primary hypertensive patients. Common carotid intima-media thickness (IMT) and brachial artery flow-mediated dilatation (FMD) were detected by ultrasonography. Arterial stiffness indicated by augmentation index (AIx) and pulse wave velocity (PWV) was assessed by arteriography. Cognitive functions were assessed by neuropsychological examination. The executive function overall score was significantly higher at 3-month follow-up than at baseline (median, 0.233 (IQR, 0.447) vs ?0.038 (0.936); P?=?.001). Three-month ACE inhibition did not produce significant improvement in IMT, FMD, AIx and PWV values. Significant negative associations were revealed between IMT and complex attention (r?=??0.598, P?=?.0008), executive function (r?=??0.617, P?=?.0005), and immediate memory (r?=??0.420, P?=?.026) overall scores at follow-up. AIx had significant negative correlations with complex attention (r?=??0.568, P?=?.001), executive function (r?=??0.374, P?=?.046), and immediate memory (r?=??0.507, P?=?.005). PWV correlated significantly and negatively with complex attention (r?=??0.490, P?=?.007). Timely and effective antihypertensive therapy with ACE inhibitors has significant beneficial effects on cognitive performance in as few as 3 months. Early ACE inhibition may have an important role in the reversal of initial impairments of cognitive function associated with hypertension-induced vascular alterations.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk arterial stiffness carotid intima-media thickness cognition flow-mediated vasodilatation hypertension
Megjelenés:	Medicine. - 98 : 34 (2019), p. 1-9. -
További szerzők:	Andrejkovics Mónika (1967-) (klinikai szakpszichológus, neuropszichológus, pszichoterapeuta) Balajthy-Hidegh Bernadett Hofgárt Gergely (1984-) (neurológus) Kardos László (1970-) (megelőző orvostan és népegészségtan szakorvos) Diószegi Ágnes (1987-) (belgyógyász) Rostás Róbert (1991-) (Orvos) Czuriga-Kovács Katalin Réka (1981-) (neurológus) Csongrádi Éva (1969-) (szakorvos) Csiba László (1952-) (neurológus, pszichiáter)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00048 GINOP Gedeon Richter research grant 4700168520-KK/186/2016 Egyéb NKFI K120042 Egyéb
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001-es BibID:	BIBFORM106314
035-os BibID:	(cikkazonosító)1081986 (Scopus)85146987410 (WoS)000917668200001
Első szerző:	Kovács Beáta (belgyógyász)
Cím:	Determining the prevalence of childhood hypertension and its concomitant metabolic abnormalities using data mining methods in the Northeastern region of Hungary / Beáta Kovács, Ákos Németh, Bálint Daróczy, Zsolt Karányi, László Maroda, Ágnes Diószegi, Bíborka Nádró, Tamás Szabó, Mariann Harangi, Dénes Páll
Dátum:	2023
ISSN:	2297-055X
Megjegyzések:	Objective: Identifying hypertension in children and providing treatment for it have a marked impact on the patients' long-term cardiovascular outcomes. The global prevalence of childhood hypertension is increasing, yet its investigation has been rather sporadic in Eastern Europe. Therefore, our goal was to determine the prevalence of childhood hypertension and its concomitant metabolic abnormalities using data mining methods. Methods: We evaluated data from 3 to 18-year-old children who visited the University of Debrecen Clinical Center's hospital throughout a 15-year study period (n = 92,198; boys/girls: 48/52%). Results: We identified a total of 3,687 children with hypertension (2,107 boys and 1,580 girls), with a 4% calculated prevalence of hypertension in the whole study population and a higher prevalence in boys (4.7%) as compared to girls (3.2%). Among boys we found an increasing prevalence in consecutive age groups in the study population, but among girls the highest prevalences are identified in the 12-15-year age group. Markedly higher BMI values were found in hypertensive children as compared to non-hypertensives in all age groups. Moreover, significantly higher total cholesterol (4.27 ? 0.95 vs. 4.17 ? 0.88 mmol/L), LDL-C (2.62 ? 0.79 vs. 2.44 ? 0.74 mmol/L) and triglyceride (1.2 (0.85-1.69) vs. 0.94 (0.7-1.33) mmol/L), and lower HDL-C (1.2 ? 0.3 vs. 1.42 ? 0.39 mmol/L) levels were found in hypertensive children. Furthermore, significantly higher serum uric acid levels were found in children with hypertension (299.2 ? 86.1 vs. 259.9 ? 73.3 ?mol/L), while glucose levels did not differ significantly. Conclusion: Our data suggest that the calculated prevalence of childhood hypertension in our region is comparable to data from other European countries and is associated with early metabolic disturbances. Data mining is an effective method for identifying childhood hypertension and its metabolic consequences.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk adolescents blood pressure children data mining hypertension metabolic parameters obesity prevalence
Megjelenés:	Frontiers in Cardiovascular Medicine. - 9 (2023), p. 1-10. -
További szerzők:	Németh Ákos (1984-) (gyógyszer-vegyészmérnök, közgazdász) Daróczy Bálint (1984-) (informatikus, matematikus) Karányi Zsolt (1961-) (biostatisztikus, bioinformatikus) Maroda László (1979-) (gyógyszerész) Diószegi Ágnes (1987-) (belgyógyász) Nádró Bíborka (1992-) (általános orvos) Szabó Tamás (1968-) (gyermekgyógyász) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Páll Dénes (1967-) (belgyógyász, kardiológus)
Pályázati támogatás:	K142273 OTKA MTA Premium Postdoctoral Fund MTA European Union Project RRF-2.3.1-21-2022-00004 Egyéb
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001-es BibID:	BIBFORM102018
035-os BibID:	(cikkazonosító)2872 (WoS)000803149000001 (Scopus)85130240685
Első szerző:	Kovács Beáta (belgyógyász)
Cím:	The Importance of Arterial Stiffness Assessment in Patients with Familial Hypercholesterolemia / Beáta Kovács, Orsolya Cseprekál, Ágnes Diószegi, Szabolcs Lengyel, László Maroda, György Paragh, Mariann Harangi, Dénes Páll
Dátum:	2022
ISSN:	2077-0383
Megjegyzések:	Cardiovascular diseases are still the leading cause of mortality due to increased atherosclerosis worldwide. In the background of accelerated atherosclerosis, the most important risk factors include hypertension, age, male gender, hereditary predisposition, diabetes, obesity, smoking and lipid metabolism disorder. Arterial stiffness is a firmly established, independent predictor of cardiovascular risk. Patients with familial hypercholesterolemia are at very high cardiovascular risk. Non-invasive measurement of arterial stiffness is suitable for screening vascular dysfunction at subclinical stage in this severe inherited disorder. Some former studies found stiffer arteries in patients with familial hypercholesterolemia compared to healthy controls, while statin treatment has a beneficial effect on it. If conventional drug therapy fails in patients with severe familial hypercholesterolemia, PCSK9 inhibitor therapy should be administered; if these agents are not available, performing selective LDL apheresis could be considered. The impact of recent therapeutic approaches on vascular stiffness is not widely studied yet, even though the degree of accelerated athero and arteriosclerosis correlates with cardiovascular risk. The authors provide an overview of the diagnosis of familial hypercholesterolemia and the findings of studies on arterial dysfunction in patients with familial hypercholesterolemia, in addition to presenting the latest therapeutic options and their effects on arterial elasticity parameters.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk PCSK9 inhibitor monoclonal antibody arterial stiffness familial hypercholesterolemia selective LDL apheresis
Megjelenés:	Journal of Clinical Medicine. - 11 : 10 (2022), p. 1-14. -
További szerzők:	Cseprekál Orsolya (1983-) (Orvos) Diószegi Ágnes (1987-) (belgyógyász) Lengyel Szabolcs (1981-) (belgyógyász) Maroda László (1979-) (gyógyszerész) Paragh György (1953-) (belgyógyász) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Páll Dénes (1967-) (belgyógyász, kardiológus)
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