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001-es BibID:BIBFORM103908
Első szerző:Nádró Bíborka (általános orvos)
Cím:Serum progranulin level in patients with newly diagnosed untreated familial hypercholesterolemia / Nádró B., Lőrincz H., Juhász L., Szentpéteri A., Sztanek F., Seres I., Páll D., Fülöp P., Paragh G., Harangi M.
Dátum:2022
ISSN:0021-9150
Megjegyzések:Background and Aims : Familial hypercholesterolemia (FH) is a monogenic form of severe hypercholesterolemia, characterized by elevated total cholesterol and low-density lipoprotein-cholesterol concentrations that, if left untreated, is associated with early onset of atherosclerosis. Progranulin (PGRN) is a recently discovered growth factor with many biological functions. PGRN has anti-inflammatory properties because it inhibits neutrophil degranulation and blocks tumor necrosis factor ? transmission, therefore, might be anti-atherogenic. To date, serum level of PGRN in patients with FH has not been studied. Methods: Eighty-one newly diagnosed, untreated patients with FH and 32 healthy control subjects were involved in our study. Serum PGRN levels were determined by ELISA. We diagnosed FH using the Dutch Lipid Clinic Network criteria. Results: We could not find significant difference in serum PGRN levels between FH patients and healthy controls (37.66?9.75 vs. 38.43?7.74 ng/mL, ns.). However, we found significant positive correlations between triglyceride, C-reactive protein (CRP), and PGRN levels (p<0.01 and p<0.01, respectively), while significant negative correlation was found between high-density lipoprotein cholesterol (HDL-C) and PGRN levels (p<0.05) both in the whole study population and in FH patients. Conclusions: Strong correlations between HDL-C, CRP and PGRN levels suggest that PGRN may exerts its anti-atherogenic effect in FH patients by alteration in HDL-C level by amelioration of inflammatory processes. Further studies on larger study populations are needed to clarify the underlying mechanisms. Funding: This presentation was supported by the Bridging Fund (Faculty of Medicine, University of Debrecen) and PD124126 project.
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
folyóiratcikk
atherosclerosis
familial hypercholesterolemia
progranulin
lipoprotein
inflammation
Megjelenés:Atherosclerosis. - 355 (2022), p. e248. -
További szerzők:Lőrincz Hajnalka (1986-) (biológus) Juhász Lilla (1990-) (általános orvos) Szentpéteri Anita (1988-) (biológus) Sztanek Ferenc (1982-) (orvos) Seres Ildikó (1954-) (biokémikus) Páll Dénes (1967-) (belgyógyász, kardiológus) Fülöp Péter (1974-) (belgyógyász, endokrinológus, lipidológus) Paragh György (1953-) (belgyógyász) Harangi Mariann (1974-) (belgyógyász, endokrinológus)
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001-es BibID:BIBFORM073991
Első szerző:Varga Viktória Evelin (biológus)
Cím:Changes in serum afamin and vitamin E levels after selective LDL apheresis / Varga Viktória Evelin, Lőrincz Hajnalka, Szentpéteri Anita, Juhász Lilla, Seres Ildikó, Paragh György Jr., Balla József, Paragh György, Harangi Mariann
Dátum:2018
ISSN:0733-2459
Megjegyzések:Background: Human afamin is a plasma vitamin E-binding glycoprotein partially associatedwith ApoA1-containing HDL subfractions. In a previous study, the serum vitamin Edecreased after LDL apheresis, while vitamin E/cholesterol ratio significantly increased. Weaimed to study the effect of LDL apheresis on serum afamin level.Methods: The serum level of afamin and oxidized LDL were measured by enzyme-linkedimmunosorbent assay in six severe heterozygous FH patients before and after their first LDLapheresis treatments and in seven healthy controls. We also investigated the changes in HDLsubfractions and ApoA1, ?- and ?-tocopherol levels during the treatment. HDL subfractionswere detected by an electrophoretic method on polyacrylamide gel (Lipoprint). Serum ?- and?-tocopherol levels were detected by gas chromatography-mass spectrometry.Results: The first treatment sessions decreased serum afamin levels by an average of 9.4%.Total cholesterol, LDL-C, HDL-C and ApoA1 levels decreased by 52.6; 61.8; 10.5 and14.1%, respectively. We found that ?- and ?-tocopherol levels markedly decreased (by 34.1and 32.9%, respectively), while ?- tocopherol/cholesterol and ?-tocopherol/cholesterol ratiossignificantly increased (by 41.4 and 40.3%, respectively). Furthermore, oxidized LDL levelssignificantly decreased and there was a shift towards the larger HDL subfractions.Conclusion: LDL apheresis moderately decreases the circulating levels of afamin parallel tolowering HDL-C and ApoA1 levels. Tocopherol levels decreases markedly compared toafamin levels, however, beneficial changes in vitamin E/cholesterol ratios, oxidized LDLlevels and HDL subfraction distribution were detected. These additional effects of LDLapheresis may result in further cardiovascular risk reduction in FH patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
LDL apheresis
vitamin E
afamin
ApoA1
Familial Hypercholesterolemia
Megjelenés:Journal Of Clinical Apheresis. - 33 : 5 (2018), p. 569-575. -
További szerzők:Lőrincz Hajnalka (1986-) (biológus) Szentpéteri Anita (1988-) (biológus) Juhász Lilla (1990-) (általános orvos) Seres Ildikó (1954-) (biokémikus) Paragh György Jr. (1978-) (bőrgyógyász) Balla József (1959-) (belgyógyász, nephrológus) Paragh György (1953-) (belgyógyász) Harangi Mariann (1974-) (belgyógyász, endokrinológus)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
GINOP
OTKA-115723
OTKA
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