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001-es BibID:	BIBFORM112881
035-os BibID:	(cikkazonosító)obad021 (WoS)001022568500001 (Scopus)85165995886
Első szerző:	Üveges Bálint (biológus, ökológus)
Cím:	Does The Glucocorticoid Stress Response Make Toads More Toxic? An Experimental Study on The Regulation of Bufadienolide Toxin Synthesis / Üveges B., Kalina C., Szabó K., Móricz Ágnes M., Holly D., Gabor C. R., Hettyey A., Bókony V.
Dátum:	2023
ISSN:	2517-4843
Megjegyzések:	Chemical defence is a crucial component of fitness in many organisms, yet the physiological regulation of defensive toxin synthesis is poorly understood, especially in vertebrates. Bufadienolides, the main defensive compounds of toads, are toxic to many predators and other natural enemies, and their synthesis can be upregulated by stressors including predation risk, high conspecific density, and pollutants. Thus, higher toxin content may be the consequence of a general endocrine stress response in toads. Therefore, we hypothesized that bufadienolide synthesis may be stimulated by elevated levels of corticosterone (CORT), the main glucocorticoid hormone of amphibians, or by upstream regulators that stimulate CORT production. To test these alternatives, we treated common toad tadpoles with exogenous CORT (exoCORT) or metyrapone (MTP, a CORT-synthesis inhibitor that stimulates upstream regulators of CORT by negative feedback) in the presence or absence of predation cues for 2 or 6 days, and subsequently measured their CORT release rates and bufadienolide content. We found that CORT release rates were elevated by exoCORT, and to a lesser extent also by MTP, regardless of treatment length. Bufadienolide content was significantly decreased by treatment with exoCORT for 6 days, but was unaffected by exposure to exoCORT for 2 days or to MTP for either 6 or 2 days. Presence or absence of predation cues affected neither CORT release rate nor bufadienolide content. Our results suggest that changes in bufadienolide synthesis in response to environmental challenges are not driven by CORT but may rather be regulated by upstream hormones of the stress response.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk stress response phenotypic plasticity corticosterone HPA axis
Megjelenés:	Integrative Organismal Biology. - 5 : 1 (2023), p. 1-13. -
További szerzők:	Kalina Csenge Szabó Krisztina (1987-) (Molekuláris biológus) Móricz Ágnes M. (kémikus) Holly Dóra Gabor, Caitlin R. Hettyey Attila (ökológus) Bókony Veronika (alkalmazott zoológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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