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001-es BibID:	BIBFORM068337
Első szerző:	Horváth Gábor
Cím:	Environmental enrichment increases PACAP levels in the CNS of adult rats / Horvath G., Kiss P., Nemeth J., Lelesz B., Tamas A., Reglodi D.
Dátum:	2015
ISSN:	0172-780X
Megjegyzések:	OBJECTIVE:Pituitary adenylate cyclase activating polypeptide (PACAP) is a pleiotropic and multifunctional neuropeptide, widely distributed throughout the body. It is involved in the regulation of various physiological and pathophysiological processes. Numerous studies have shown that PACAP is involved in the development of the central nervous system and has neuroprotective effects. Environmental enrichment is also protective in various injuries, partially through involvement of trophic factors. The interaction between PACAP levels in the brain and environmental effects has not been studied yet. The aim of the present study was to investigate whether environmental enrichment influences PACAP levels of different brain areas in rats.METHODS:Wistar rats were exposed to enriched environment in adulthood for 3 weeks. PACAP27- and PACAP38-like immunoreactivities were measured with a specific and sensitive radioimmunoassay in homogenates of different brain areas: brainstem, cerebellum, diencephalon and telencephalon.RESULTS:We found that levels of both PACAP27- and PACAP38-like immunoreactivities showed significant increases in most brain areas after a 3-week-long exposure to enriched conditions. Thus, similarly to several other CNS injuries, enriched environment induced elevation in PACAP levels.CONCLUSION:As PACAP has strong neuroprotective effects, the elevation observed after exposure to enriched environment is suggested to play a role in the protective effects of such an environment as part of the endogenous neuroprotective machinery in adult rats.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban PACAP RIA CNS
Megjelenés:	Neuroendocrinology Letters 36 : 2 (2015), p. 143-147. -
További szerzők:	Kiss Péter (Pécs) Németh József (Pécs) Lelesz Beáta (1989-) (molekuláris biológus) Tamás Andrea (Idegtudomány) (Pécs) Reglődi Dóra (Idegtudományok)
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001-es BibID:	BIBFORM078047
Első szerző:	Sárszegi Zsolt
Cím:	Examination of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) as a Potential Biomarker in Heart Failure Patients / Zsolt Sarszegi, Dora Szabo, Balazs Gaszner, Attila Konyi, Dora Reglodi, Jozsef Nemeth, Beata Lelesz, Beata Polgar, Adel Jungling, Andrea Tamas
Dátum:	2019
ISSN:	0895-8696 1559-1166
Megjegyzések:	Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic and multifunctional neuropeptide having neurotrophic, neuroprotective, and general cytoprotective actions in a variety of tissues based on its anti-apoptotic, anti-inflammatory, and antioxidant effects. Several studies have demonstrated its cardioprotective effects in vitro and in various animal models. However, few data are available on the presence of PACAP in human cardiac tissues and its role in the pathomechanism and progression of different cardiac disorders, particularly heart failure. Earlier, our research group has shown PAC1 receptor immunoreactivity in human heart tissue samples and we have found significantly elevated PACAP27- and PACAP38-like immunoreactivity in ischemic cardiac samples compared to valvular abnormalities with radioimmunoassay. In the last few years, numerous studies examined the presence and the changes of PACAP levels in different human tissue samples and biological fluids to show alterations in different physiological and pathological conditions. Therefore, the aim of the present study was to measure the alterations of blood PACAP levels in chronic heart failure caused by primary dilated cardiomyopathy or ischemic cardiomyopathy and to examine the possible relationship between serum levels of PACAP, N-terminal prohormone of brain natriuretic peptide (NT-proBNP), and systolic left ventricular function, the most reliable biomarkers of heart failure. In the group of mild heart failure patients, a significant strong negative correlation was detected. Furthermore, in moderate heart failure, we found a significant moderate negative correlation between PACAP and NT-proBNP levels only in ischemic subgroup. Positive correlation was found between serum PACAP level and ejection fraction only in patientswith heart failure due to ischemic cardiomyopathy but not in patients with primary dilated cardiomyopathy. In summary, remarkable differences were observed between the ischemic and non-ischemic heart failure suggesting that PACAP might play an important role in the pathomechanism and progression of ischemic heart failure and it might be a potential biomarker of cardiac diseases in the future.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Dilated cardiomyopathy Heart failure NT-proBNP PACAP
Megjelenés:	Journal of Molecular Neuroscience. - 68 : 3 (2019), p. 368-376. -
További szerzők:	Szabó Dóra Gaszner Balázs (Neuroanatómia) Kónyi Attila Reglődi Dóra (Idegtudományok) Németh József (1954-) (vegyész, analitikus) Lelesz Beáta (1989-) (molekuláris biológus) Polgár Beáta Jungling Adél Tamás Andrea (Idegtudomány) (Pécs)
Pályázati támogatás:	K119759 OTKA GINOP-2.3.2-15-2016-00050 OTKA EFOP-3.6.1-16-2016-00004 EFOP EFOP-3.6.2-16-2017-00009 EFOP EFOP-3.6.2-16-2017-00008 EFOP TAMOP 4.2.4.A/2-11-1-2012-0001 TÁMOP UNKP-16-4-IV New National Excellence Program of the Ministry of Human Capacities UNKP
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001-es BibID:	BIBFORM068338
Első szerző:	Tamás Andrea (Idegtudomány) (Pécs)
Cím:	Examination of PACAP-Like Immunoreactivity in Urogenital Tumor Samples / Andrea Tamas, Andras Javorhazy, Dora Reglodi, Donat Peter Sarlos, Daniel Banyai, David Semjen, Jozsef Nemeth, Beata Lelesz, Daniel Balazs Fulop, Zalan Szanto
Dátum:	2016
ISSN:	0895-8696
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal of Molecular Neuroscience. - 59 : 2 (2016), p. 177-183. -
További szerzők:	Jávorházy András Reglődi Dóra (Idegtudományok) Sarlós Donát P. Bányai Dániel Semjén Dávid Németh József (Pécs) Lelesz Beáta (1989-) (molekuláris biológus) Fülöp Dániel Balázs Szántó Zalán
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