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001-es BibID:	BIBFORM082608
035-os BibID:	(cikkazonosító)2861 (WOS)000504275200001 (Scopus)85077285551
Első szerző:	Peles Ferenc (mikrobiológia, élelmiszer-mikrobiológia, minőségügy)
Cím:	Adverse Effects, Transformation and Channeling of Aflatoxins Into Food Raw Materials in Livestock / Ferenc Peles, Péter Sipos, Zoltán Győri, Walter P. Pfliegler, Federica Giacometti, Andrea Serraino, Giampiero Pagliuca, Teresa Gazzotti, István Pócsi
Dátum:	2019
ISSN:	1664-302X
Megjegyzések:	Aflatoxins are wide-spread harmful carcinogenic secondary metabolites produced by Aspergillus species, which cause serious feed and food contaminations and affect farm animals deleteriously with acute or chronic manifestations of mycotoxicoses. On farm, both pre-harvest and post-harvest strategies are applied to minimize the risk of aflatoxin contaminations in feeds. The great economic losses attributable to mycotoxin contaminations have initiated a plethora of research projects to develop new, effective technologies to prevent the highly toxic effects of these secondary metabolites on domestic animals and also to block the carry-over of these mycotoxins to humans through the food chain. Among other areas, this review summarizes the latest findings on the effects of silage production technologies and silage microbiota on aflatoxins, and it also discusses the current applications of probiotic organisms and microbial products in feeding technologies. After ingesting contaminated foodstuffs, aflatoxins are metabolized and biotransformed differently in various animals depending on their inherent and acquired physiological properties. These mycotoxins may cause primary aflatoxicoses with versatile, species-specific adverse effects, which are also dependent on the susceptibility of individual animals within a species, and will be a function of the dose and duration of aflatoxin exposures. The transfer of these undesired compounds from contaminated feed into food of animal origin and the aflatoxin residues present in foods become an additional risk to human health, leading to secondary aflatoxicoses. Considering the biological transformation of aflatoxins in livestock, this review summarizes (i) the metabolism of aflatoxins in different animal species, (ii) the deleterious effects of the mycotoxins and their derivatives on the animals, and (iii) the major risks to animal health in terms of the symptoms and consequences of acute or chronic aflatoxicoses, animal welfare and productivity. Furthermore, we traced the transformation and channeling of Aspergillus-derived mycotoxins into food raw materials, particularly in the case of aflatoxin contaminated milk, which represents the major route of human exposure among animal-derived foods. The early and reliable detection of aflatoxins in feed, forage and primary commodities is an increasingly important issue and, therefore, the newly developed, easy-to-use qualitative and quantitative aflatoxin analytical methods are also summarized in the review.
Tárgyszavak:	Agrártudományok Élelmiszertudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Frontiers in Microbiology. - 10 (2019), p. 1-26. -
További szerzők:	Sipos Péter (1975-) (agrármérnök) Győri Zoltán (1948-) (vegyész) Pfliegler Valter Péter (1986-) (molekuláris biológus) Giacometti, Federica Serraino, Andrea Pagliuca, Giampiero Gazzotti, Teresa Pócsi István (1961-) (vegyész)
Pályázati támogatás:	Debreceni Egyetem Biotechnológia tématerületi program FIKP 2018-1.2.1-NKP-2018-00002 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM082438
035-os BibID:	(cikkazonosító)2921 (WOS)000517458200001 (Scopus)85083912366
Első szerző:	Pfliegler Valter Péter (molekuláris biológus)
Cím:	The Aspergilli and their mycotoxins : metabolic interactions with plants and the soil biota / Valter P. Pfliegler, István Pócsi, Zoltán Győri, Tünde Pusztahelyi
Dátum:	2020
ISSN:	1664-302X
Megjegyzések:	Species of the highly diverse fungal genus Aspergillus are well-known agricultural pests and, most importantly, producers of various mycotoxins threatening food safety worldwide. Mycotoxins are studied predominantly from the perspectives of human and livestock health. Meanwhile, their roles are far less known in nature. However, to understand the factors behind mycotoxin production, the roles of the toxins of the Aspergilli must be understood from a complex ecological perspective, taking mold-plant, mold-microbe, and mold-animal interactions into account. The Aspergilli may switch between saprophytic and pathogenic lifestyles, and the production of secondary metabolites, such as mycotoxins, may vary according to these fungal ways of life. Recent studies highlighted the complex ecological network of soil microbiotas determining the niches that Aspergilli can fill in. Interactions with the soil microbiota and soil macro-organisms determine the role of secondary metabolite production to a great extent. While, upon infection of plants, metabolic communication including fungal secondary metabolites like aflatoxins, gliotoxin, patulin, cyclopiazonic acid, ochratoxin, influences the fate of both the invader and the host. In this review, the role of mycotoxin producing Aspergillus species and their interactions in the ecosystem are discussed. We intend to highlight the complexity of the roles of the main toxic secondary metabolites as well as their fate in natural environments and agriculture, a field that still has important knowledge gaps.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Frontiers in Microbiology. - 10 (2020), p. 1-45. -
További szerzők:	Pócsi István (1961-) (vegyész) Győri Zoltán (1948-) (vegyész) Pusztahelyi Tünde (1969-) (biológus, angol-magyar szakfordító)
Pályázati támogatás:	NKFIH 2018-1.2.1-NKP Egyéb OTKA K119494 OTKA
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM074051
035-os BibID:	(cikkazonosító)1193 (WOS)000434951800001 (Scopus)85048341000
Első szerző:	Sipiczki Mátyás (biológus)
Cím:	Birth-and-Death Evolution and Reticulation of ITS Segments of Metschnikowia andauensis and Metschnikowia fructicola rDNA Repeats / Sipiczki Matthias, Horvath Eniko, Pfliegler Walter P.
Dátum:	2018
ISSN:	1664-302X
Megjegyzések:	The internal transcribed spacer (ITS) region (ITS1, 5.8S rDNA, and ITS2) separates the genes coding for the SSU 18S and the LSU 26S genes in the rDNA units which are organized into long tandem arrays in the overwhelming majority of fungi. As members of a multigenic family, these units are subject of concerted evolution, which homogenizes their sequences. Exceptions have been observed in certain groups of plants and in a few fungal species. In our previous study we described exceptionally high degree of sequence diversity in the D1/D2 domains of two pulcherrimin-producing Metschnikowia (Saccharomycotina) species which appeared to evolve by reticulation. The major goals of this study were the examination of the diversity of the ITS segments and their evolution. We show that the ITS sequences of these species are not homogenized either, differ from each other by up to 38 substitutions and indels which have dramatic effects on the predicted secondary structures of the transcripts. The high intragenomic diversity makes the D1/D2 domains and the ITS spacers unsuitable for barcoding of these species and therefore the taxonomic position of strains previously assigned to them needs revision. By analyzing the genome sequence of the M. fructicola type strain, we also show that the rDNA of this species is fragmented, contains pseudogenes and thus evolves by the birth-and-death mechanism rather than by homogenisation, which is unusual in yeasts. The results of the network analysis of the sequences further indicate that the ITS regions are also involved in reticulation. M. andauensis and M. fructicola can form interspecies hybrids and their hybrids segregate, providing thus possibilities for reticulation of the rDNA repeats.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk structure prediction yeast ribosomal RNA ITS evolution pseudogene reticulation hybridisation
Megjelenés:	Frontiers in Microbiology. - 9 (2018), p. 1-16. -
További szerzők:	Horváth Enikő (1987-) (biológus) Pfliegler Valter Péter (1986-) (molekuláris biológus)
Pályázati támogatás:	K-124417 Egyéb TÁMOP-4.2.4.A/2-11/1-2012-0001 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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