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001-es BibID:	BIBFORM083072
Első szerző:	Csikai Enikő
Cím:	Influence of angiotensin-converting enzyme inhibition on reversibility of alterations in arterial wall and cognitive performance associated with early hypertension : a follow-up study / Csikai Enikő, Andrejkovics Mónika, Balajthy-Hidegh Bernadett, Hofgárt Gergely, Kardos László, Diószegi Ágnes, Rostás Róbert, Czuriga-Kovács Katalin Réka, Csongrádi Éva, Csiba László
Dátum:	2019
ISSN:	0025-7974
Megjegyzések:	The importance of optimal blood pressure control for preventing or reducing the impairment of vascular and cognitive functions is well known. However, the reversibility of early alterations in vascular and cognitive functions through antihypertensive agents is under-investigated. In this study, we evaluated the influence of 3 months of angiotensin-converting enzyme (ACE) inhibition treatment on the morphological and functional arterial wall and cognitive performance changes in 30 newly diagnosed primary hypertensive patients. Common carotid intima-media thickness (IMT) and brachial artery flow-mediated dilatation (FMD) were detected by ultrasonography. Arterial stiffness indicated by augmentation index (AIx) and pulse wave velocity (PWV) was assessed by arteriography. Cognitive functions were assessed by neuropsychological examination. The executive function overall score was significantly higher at 3-month follow-up than at baseline (median, 0.233 (IQR, 0.447) vs ?0.038 (0.936); P?=?.001). Three-month ACE inhibition did not produce significant improvement in IMT, FMD, AIx and PWV values. Significant negative associations were revealed between IMT and complex attention (r?=??0.598, P?=?.0008), executive function (r?=??0.617, P?=?.0005), and immediate memory (r?=??0.420, P?=?.026) overall scores at follow-up. AIx had significant negative correlations with complex attention (r?=??0.568, P?=?.001), executive function (r?=??0.374, P?=?.046), and immediate memory (r?=??0.507, P?=?.005). PWV correlated significantly and negatively with complex attention (r?=??0.490, P?=?.007). Timely and effective antihypertensive therapy with ACE inhibitors has significant beneficial effects on cognitive performance in as few as 3 months. Early ACE inhibition may have an important role in the reversal of initial impairments of cognitive function associated with hypertension-induced vascular alterations.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk arterial stiffness carotid intima-media thickness cognition flow-mediated vasodilatation hypertension
Megjelenés:	Medicine. - 98 : 34 (2019), p. 1-9. -
További szerzők:	Andrejkovics Mónika (1967-) (klinikai szakpszichológus, neuropszichológus, pszichoterapeuta) Balajthy-Hidegh Bernadett Hofgárt Gergely (1984-) (neurológus) Kardos László (1970-) (megelőző orvostan és népegészségtan szakorvos) Diószegi Ágnes (1987-) (belgyógyász) Rostás Róbert (1991-) (Orvos) Czuriga-Kovács Katalin Réka (1981-) (neurológus) Csongrádi Éva (1969-) (szakorvos) Csiba László (1952-) (neurológus, pszichiáter)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00048 GINOP Gedeon Richter research grant 4700168520-KK/186/2016 Egyéb NKFI K120042 Egyéb
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001-es BibID:	BIBFORM042412
Első szerző:	Léránt Brigitta
Cím:	Morphological, hemodynamic and stiffness changes in arteries of young smokers / Brigitta Léránt, Christina Straesser, Réka Katalin Kovács, László Oláh, László Kardos, László Csiba
Dátum:	2012
ISSN:	2211-968X
Megjegyzések:	Aim The aim of our investigations was to detect the acute and chronic effects of cigarette smoking on arterial wall thickness and stiffness in young, healthy volunteers. We also performed a one-year follow-up to define the possible changes. Subjects We recruited 25 non-smoking and 25 smoking university students aged 19-33. Exclusion criteria were any known diseases, abnormally high cholesterol levels and body mass index (BMI) above 30 kg/m2. Methods We defined the intima-media thickness on both common carotid arteries by using B-mode ultrasonography and we measured the hemodynamic and stiffness parameters with the help of arteriograph. In case of smokers we also investigated the acute effects after smoking one cigarette. In the follow-up study we measured 15 non-smokers and 13 smokers again. Results In the smoking group morphological, stiffness and hemodynamic parameters showed significantly higher values compared to non-smokers. Concerning the acute effects we detected a significant increase in stiffness and hemodynamic parameters after smoking one cigarette. Gender differences were also found in the smoking group. Unadjusted to age, gender and smoking status there was a significant correlation between intima-media thickness and pulse wave velocity. We could not find any progression in smokers after one year, while there was an improvement in intima-media thickness and augmentation index in non-smokers. Conclusion Early atherosclerotic processes due to smoking can be detected even at a young age, in healthy university students. One year regular smoking does not result in detectable changes.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Perspectives in Medicine. - 1 : 1-12 (2012), p. 152-155. -
További szerzők:	Straesser, Christina Czuriga-Kovács Katalin Réka (1981-) (neurológus) Oláh László (1967-) (neurológus) Kardos László (1970-) (megelőző orvostan és népegészségtan szakorvos) Csiba László (1952-) (neurológus, pszichiáter)
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001-es BibID:	bibEBI00026266
Első szerző:	Majer Réka
Cím:	Neuropsychiatric symptoms, quality of life and caregivers' burden in dementia / Majer Réka, Adeyi Olar, Bagoly Zsuzsa, Simon Viktória, Csiba László, Kardos László, Hortobágyi Tibor, Frecska Ede
Dátum:	2020
ISSN:	2391-5463 1911-2092
Megjegyzések:	The objective of this research is to identify the relationship between the neuropsychiatric symptoms (NPSs) of patients with major neurocognitive disorder (mNCD), their quality of life, illness intrusiveness and the caregiver's burden. We assessed 131 patients with mNCD. Examination methods included WHO well-being index short version, illness intrusiveness rating scale, Alzheimer's Disease Assessment Scale-Cog, Mini Mental State Examination and neuropsychiatric inventory. The results were analysed using standard statistical tests. In our sample, the prevalence of NPSs is 100%. A significant correlation (p < 0.0001) was observed with quality of life and illness intrusiveness. Additionally, a strong relationship was observed between NPSs and the caregiver's burden (r = 0.9). The result is significantly twice as much stronger in comparison to the relationship between NPS and cognitive symptoms (r = 0.4). This is the first study in Hungary to assess the impact of NPS on the burden of relatives and quality of life. NPS had twice stronger impact on caregivers' burden than cognitive decline. However, further studies are needed to assess the sub-syndromes in mNCD in relation to NPS.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Open Medicine. - 15 : 1 (2020), p. 905-914. -
További szerzők:	Adeyi, Olar Bagoly Zsuzsa (1978-) (orvos) Simon Viktória Csiba László (1952-) (neurológus, pszichiáter) Kardos László (1970-) (megelőző orvostan és népegészségtan szakorvos) Hortobágyi Tibor (1965-) (patológus) Frecska Ede (1953-) (pszichiáter)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00048 GINOP SZTE ÁOK-KKA No. 5S 567 (A202) Egyéb OTKA-NKFIH-SNN 132999 OTKA K120042 Nemzeti Kutatási, Fejlesztési és Innovációs Alap Egyéb Nemzeti Agykutatási Program 2.0 (2017-1.2.1-NKP-2017-00002 Egyéb
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