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001-es BibID:	BIBFORM054328
Első szerző:	Sármay Gabriella
Cím:	Human Type II Fcγ Receptors Inhibit B Cell Activation by Interacting with the p21ras-dependent Pathway / Gabriella Sármay, Gábor Koncz, János Gergely
Dátum:	1996
ISSN:	0021-9258 1083-351X
Megjegyzések:	Co-ligation of antigen receptors and type II Fc gamma receptors (Fc gamma RIIb) on B cells interrupts signal transduction and ultimately inhibits antibody production. We have identified p52 She in the Fc gamma RIIb1-specific immunoprecipitates isolated from the membrane fraction of BL41 Burkitt lymphoma cells following B cell receptor-Fc gamma RIIb1 co-ligation. The insolubilized synthetic peptide representing the phosphorylated form of the tyrosine-based inhibitory moth of Fc gamma RIIb also binds She from the lysates of activated but not from resting BL41 cells. This suggests that the binding does not depend on the interaction of Fc gamma RIIb1-phosphotyrosine with the SH2 domain of She. Tyr phosphorylation of Fc gamma RIIb1-associated She is low, indicating an impaired function. She is implicated in regulating p21(ras) activation; thus, we have compared p21(ras) activities in BL41 cells treated in different ways. p21(ras) activity is reduced when B cell receptor and Fc gamma RIIb1 are co-ligated. p21(ras) couples protein-tyrosine kinase-dependent events to the Ser/Thr kinase-mediated signaling pathway leading to the activation of mitogen-activated protein kinases (MAPK). Our results show that B cell receptor-Fc gamma RIIb1 co-crosslinking partially inhibits mitogen-activated protein kinase activity. We conclude that Fc gamma RIIb1-dependent inhibition of human B cell activation may be based on interrupting signal transduction between protein-tyrosine kinases and the p21(ras)/mitogen-activated protein kinase-dependent activation pathway.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban PROTEIN-KINASE-C CROSS-LINKING TYROSINE PHOSPHORYLATION LYMPHOCYTES SHC IMMUNOGLOBULIN P21(RAS) COMPLEX FC-GAMMA-RIIB1 STIMULATION
Megjelenés:	The Journal of Biological Chemistry. - 271 : 48 (1996), p. 30499-30504. -
További szerzők:	Koncz Gábor (1970-) (biológus, immunológus) Gergely János
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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