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001-es BibID:	BIBFORM054309
035-os BibID:	PMID: 11897497
Első szerző:	Kövesdi Dorottya
Cím:	Developmental differences in B cell receptor-induced signal transduction / Dorottya Kövesdi, Gábor Koncz, Roland Iványi-Nagy, Yael Caspi, Masamichi Ishiai, Tomohiro Kurosaki, János Gergely, Joseph Haimovich, Gabriella Sármay
Dátum:	2002
ISSN:	0898-6568
Megjegyzések:	We have compared early signaling events at various stages of B cell differentiation using established mouse cell lines. Clustering of pre-B cell antigen receptor (BCR) or BCR induced the tyrosine phosphorylation of various proteins in all cells, although the phosphorylation pattern differed. In spite of the pre-BCR-induced tyrosine phosphorylation, we could not detect an intracellular Ca(2+) signal in pre-B cells. However. coclustering of the pre-BCR with CD19 did induce Ca(2+) mobilization. In contrast to the immature and mature B cells, where the B cell linker protein (BLNK) went through inducible tyrosine phosphorylation upon BCR clustering, we observed a constitutive tyrosine phosphorylation of BLNK in pre-B cell lines. Both BLNK and phospholipase C (PLC)gamma were raft associated in unstimulated pre-B cells, and this could not be enhanced by pre-BCR engagement, suggesting a ligand-independent PLC-gamma-mediated signaling. Further results indicate that the cell lines representing the immature stage are more sensitive to BCR-, CD19- and type II receptors binding the Fe part of IgG (FcgammaRIIb)mediated signals than mature B cells.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban B cell development receptors signaling tyrosine phosphorylation
Megjelenés:	Cellular Signalling. - 14 : 6 (2002), p. 563-572. -
További szerzők:	Koncz Gábor (1970-) (biológus, immunológus) Iványi-Nagy Roland Caspi, Yael Ishiai, Masamichi Kurosaki, Tomohiro Gergely János Haimovich, Joseph Sármay Gabriella
Pályázati támogatás:	Bolyai János Kutatási Ösztöndíj Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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