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001-es BibID:	BIBFORM109052
035-os BibID:	(cikkazonosító)401 (Scopus)85151113623 (WoS)000953989400001
Első szerző:	Diószegi Ágnes (belgyógyász)
Cím:	Role of Altered Metabolism of Triglyceride-Rich Lipoprotein Particles in the Development of Vascular Dysfunction in Systemic Lupus Erythematosus / Diószegi Ágnes, Lőrincz Hajnalka, Kaáli Eszter, Soltész Pál, Perge Bianka, Varga Éva, Harangi Mariann, Tarr Tünde
Dátum:	2023
ISSN:	2218-273X
Megjegyzések:	Background: Impaired lipid metabolism contributes to accelerated inflammatory responses in addition to promoting the formation of atherosclerosis in systemic lupus erythematosus (SLE). We aimed to evaluate the lipid profile, inflammatory markers, and vascular diagnostic tests in active SLE patients to clarify the association between dyslipidemia and early vascular damage. Patients and Methods: 51 clinically active SLE patients and 41 age- and gender-matched control subjects were enrolled in the study. Lipoprotein subfractions were detected by Lipoprint. Brachial artery flow-mediated dilation and common carotid intima-media thickness were detected by ultrasonography. Arterial stiffness indicated by augmentation index (Aix) and pulse wave velocity was measured by arteriography. Results: We found significantly higher Aix, higher VLDL ratio, plasma triglyceride, ApoB100, and small HDL, as well as lower HDL-C, large HDL, and ApoA1 in patients with SLE. There was a significant positive correlation of Aix with triglyceride, VLDL, IDL-C, IDL-B, and LDL1. A backward stepwise multiple regression analysis showed IDL-C subfraction to be the best predictor of Aix. Conclusions: Our results indicate that in young patients with SLE, triglyceride-rich lipoproteins influence vascular function detected by Aix. These parameters may be assessed and integrated into the management plan for screening cardiovascular risk in patients with SLE.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk systemic lupus erythematosus carotid intima-media thickness augmentation index flow-mediated dilation triglyceride very low-density lipoprotein intermediate-density lipoprotein triglyceride-rich lipoproteins
Megjelenés:	Biomolecules. - 13 : 3 (2023), p. 1-13. -
További szerzők:	Lőrincz Hajnalka (1986-) (biológus) Kaáli Eszter Soltész Pál (1961-) (belgyógyász, kardiológus) Perge Bianka Varga Éva (1982-) (belgyógyász) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Tarr Tünde (1976-) (belgyógyász, allergológus és klinikai immunológus)
Pályázati támogatás:	Tématerületi Kiválósági Program Egyéb K142273 NKFIH TKP2021-EGA-18 Egyéb TKP2021-EGA Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM099738
035-os BibID:	(WoS)000748218100001 (Scopus)85122675323
Első szerző:	Juhász Imre (belgyógyász)
Cím:	Afamin Levels and Their Correlation with Oxidative and Lipid Parameters in Non-diabetic, Obese Patients / Imre Juhász, Szilvia Ujfalusi, Ildikó Seres, Hajnalka Lőrincz, Viktória Evelin Varga, György Paragh Jr., Sándor Somodi, Mariann Harangi, György Paragh
Dátum:	2022
ISSN:	2218-273X
Megjegyzések:	Background: Afamin is a liver-produced bioactive protein and features α-and γ-tocopherol binding sites. Afamin levels are elevated in metabolic syndrome and obesity and correlate well with components of metabolic syndrome. Afamin concentrations, correlations between afamin and vitamin E, afamin and lipoprotein subfractions in non-diabetic, obese patients have not been fully examined. Methods: Fifty non-diabetic, morbidly obese patients and thirty-two healthy, normal-weight individuals were involved in our study. The afamin concentrations were measured by ELISA. Lipoprotein subfractions were determined with gel electrophoresis. Gas chromatography-mass spectrometry was used to measure α-and γ tocopherol levels. Results: Afamin concentrations were significantly higher in the obese patients compared to the healthy control (70.4 ± 12.8 vs. 47.6 ± 8.5 ?g/mL, p < 0.001). Positive correlations were found between afamin and fasting glucose, HbA1c, hsCRP, triglyceride, and oxidized LDL level, as well as the amount and ratio of small HDL subfractions. Negative correlations were observed between afamin and mean LDL size, as well as the amount and ratio of large HDL subfractions. After multiple regression analysis, HbA1c levels and small HDL turned out to be independent predictors of afamin. Conclusions: Afamin may be involved in the development of obesity-related oxidative stress via the development of insulin resistance and not by affecting alpha- and gamma-tocopherol levels.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Biomolecules. - 12 : 1 (2022), p. 1-11. -
További szerzők:	Ujfalusi Szilvia (1990-) (belgyógyász) Seres Ildikó (1954-) (biokémikus) Lőrincz Hajnalka (1986-) (biológus) Varga Viktória Evelin (1988-) (biológus) Paragh György Jr. (1978-) (bőrgyógyász) Somodi Sándor (1977-) (belgyógyász) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Paragh György (1953-) (belgyógyász)
Pályázati támogatás:	NKFIH K115723 Egyéb GINOP-2.3.2-15-2016-00005 GINOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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