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001-es BibID:	BIBFORM070452
035-os BibID:	(cikkazonosító)e0177282 (WOS)000401672400034 (Scopus)85019396082
Első szerző:	Csősz Éva (biokémikus, molekuláris biológus)
Cím:	Proteomics investigation of OSCC-specific salivary biomarkers in a Hungarian population highlights the importance of identification of population-tailored biomarkers / Csősz Éva, Lábiscsák Péter, Kalló Gergő, Márkus Bernadett, Emri Miklós, Szabó Adrienn, Tar Ildikó, Tőzsér József, Kiss Csongor, Márton Ildikó
Dátum:	2017
ISSN:	1932-6203
Megjegyzések:	Oral squamous cell carcinoma (OSCC) accounting for about 90% of malignant oral lesionsis the 6th most common malignancy worldwide. Diagnostic delay may contribute to dismalsurvival rate therefore, there is a need for developing specific and sensitive biomarkers toimprove early detection. Hungarian population occupies the top places of statistics regardingOSCC incidence and mortality figures therefore, we aimed at finding potential salivaryprotein biomarkers suitable for the Hungarian population. In this study we investigated 14proteins which were previously reported as significantly elevated in saliva of patients withOSCC. In case of IL-1?, IL-1?, IL-6, IL-8, TNF-? and VEGF a Luminex-based multiplex kitwas utilized and the salivary concentrations were determined. In case of catalase, profilin-1,S100A9, CD59, galectin-3-bindig protein, CD44, thioredoxin and keratin-19, SRM-basedtargeted proteomic method was developed and the relative amount of the proteins wasdetermined in the saliva of patients with OSCC and controls. After several rounds of optimizationand using stable isotope-containing peptides, we developed an SRM-based methodfor rapid salivary protein detection. The validation of the selected potential biomarkers byELISA revealed salivary protein S100A9 and IL-6 as useful protein biomarkers for OSCCdetection improving the diagnostic accuracy for OSCC in the Hungarian population.A noninvasivediagnostic method to detect biomarkers useful for the early diagnosis of OSCC wasdeveloped. This can be an attractive strategy in screening saliva samples collected in anation-wide multi-centric study in order to decrease morbidity, mortality, to enhance survivalrate and to improve quality of life. The heterogeneity of protein biomarkers found in differentethnic groups presented in the literature highlights the importance of identification of population-tailored protein biomarkers.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk OSCC salivary biomarkers
Megjelenés:	Plos One. - 12 : 5 (2017), p. 1-21. -
További szerzők:	Lábiscsák Péter Kalló Gergő (1989-) (molekuláris biológus) Márkus Bernadett (1989-) (molekuláris biológus) Emri Miklós (1962-) (fizikus) Szabó Adrienn (1965-) (egyetemi tanársegéd, fogszakorvos) Tar Ildikó (1967-) (fogszakorvos) Tőzsér József (1959-) (molekuláris biológus, biokémikus, vegyész) Kiss Csongor (1956-) (hematológus, onkológus) Márton Ildikó (1954-) (fogszakorvos)
Pályázati támogatás:	OTKA-105034 OTKA 4.2.2.D-15/1/KONV-2015-0016 TÁMOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM114402
035-os BibID:	(cikkazonosító)13657 (scopus)85170347560 (wos)001061114800001
Első szerző:	Kalló Gergő (molekuláris biológus)
Cím:	Salivary Chemical Barrier Proteins in Oral Squamous Cell Carcinoma-Alterations in the Defense Mechanism of the Oral Cavity / Kalló Gergő, Bertalan Petra Magdolna, Márton Ildikó, Kiss Csongor, Csősz Éva
Dátum:	2023
ISSN:	1422-0067
Megjegyzések:	Oral squamous cell carcinoma (OSCC) is one of the most frequent types of head and neck cancer. Despite the genetic and environmental risk factors, OSCC is also associated with microbial infections and/or dysbiosis. The secreted saliva serves as the chemical barrier of the oral cavity and, since OSCC can alter the protein composition of saliva, our aim was to analyze the effect of OSCC on the salivary chemical barrier proteins. Publicly available datasets regarding the analysis of salivary proteins from patients with OSCC and controls were collected and examined in order to identify differentially expressed chemical barrier proteins. Network analysis and gene ontology (GO) classification of the differentially expressed chemical barrier proteins were performed as well. One hundred and twenty-seven proteins showing different expression pattern between the OSCC and control groups were found. Protein?protein interaction networks of up- and down-regulated proteins were constructed and analyzed. The main hub proteins (IL-6, IL-1B, IL-8, TNF, APOA1, APOA2, APOB, APOC3, APOE, and HP) were identified and the enriched GO terms were examined. Our study highlighted the importance of the chemical barrier of saliva in the development of OSCC.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk oral squamous cell carcinoma OSCC antimicrobial and immunomodulatory proteins AMP Saliva Chemical barrier
Megjelenés:	International Journal Of Molecular Sciences. - 24 : 17 (2023), p. 1-20. -
További szerzők:	Bertalan Petra Magdolna (1996-) (klinikai laboratóriumi kutató, PhD hallgató) Márton Ildikó (1954-) (fogszakorvos) Kiss Csongor (1956-) (hematológus, onkológus) Csősz Éva (1977-) (biokémikus, molekuláris biológus)
Pályázati támogatás:	GINOP-2.3.3-15-2016-00020 GINOP NKFIH K143021 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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