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001-es BibID:	BIBFORM091835
Első szerző:	Börzsei Denise
Cím:	Exercise-mitigated sex-based differences in aging : from genetic alterations to heart performance / Denise Börzsei, Dániel Priksz, Renáta Szabó, Mariann Bombicz, Zoltán Karácsonyi, László G. Puskás, Liliána Z. Fehér, Zsolt Radák, Krisztina Kupai, Anikó Magyariné Berkó, Csaba Varga, Béla Juhász, Aniko Pósa
Dátum:	2021
ISSN:	0363-6135
Megjegyzések:	The prevalence of cardiovascular diseases dramatically increases with age; therefore, striving to maintain a physiological heart function is particularly important. Our aim was to study the voluntary exercise-evoked cardioprotective effects in aged male and female rats, from genetic alterations to changes in heart performance. We divided 20-month-old female and male Wistar rats to control and running groups. After the 12-wk-long experimental period, echocardiographic measurements were performed. Afterwards, hearts were either removed for biochemical measurements or mounted into a Langendorff-perfusion system to detect infarct size. The following genes and their proteins were analyzed from heart: catechol-O-methyltransferase (Comt), endothelin-1 (Esm1), Purkinje cell protein-4 (Pcp4), and osteoglycin (Ogn). Recreational exercise caused functional improvements; however, changes were more prominent in males. Cardiac expression of Comt and Ogn was reduced as a result of exercise in aged males, whereas Pcp4 and Esm1 showed a marked overexpression, along with a markedly improved diastolic function. The key result of this study is that exercise enhanced the expression of the Pcp4 gene and protein, a recently described regulator of calcium balance in cardiomyocytes, and suppressed Comt and Ogn gene expression, which has been associated with impaired cardiac function. In addition, as a result of exercise, a significant improvement was observed in the size of infarct elicited by left anterior descending coronary artery occlusion. Our results clearly show that age and sex-dependent changes were both apparent in key proteins linked to cardiovascular physiology. Exercise-moderated fundamental genetic alterations may have contributed to the functional adaptation of the heart.NEW & NOTEWORTHY Voluntary exercise has proved to be an effective therapeutic tool to improve cardiac function in aged rats with clearly visible sex differences. Long-term exercise is associated with decreased Ogn and Comt expression and enhanced presence of Pcp4 and Esm1 genes. Sex-dependent changes were also observed in the expression of the cardiovascular key proteins. Fundamental alterations in gene and protein expression may contribute to the improvement of cardiac performance.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Pcp4 aging echocardiography exercise gene expression
Megjelenés:	American Journal Of Physiology-Heart And Circulatory Physiology. - 320 : 2 (2021), p. 854-866. -
További szerzők:	Priksz Dániel (1989-) (farmakológus) Szabó Renáta Bombicz Mariann (1987-) (gyógyszerész) Karácsonyi Zoltán (1975-) (ortopéd és baleseti sebész) Puskás László G. Fehér Liliána Z. (Szeged) Radák Zsolt Kupai Krisztina Magyariné Berkó Anikó Varga Csaba (orvos) Juhász Béla (1978-) (kísérletes farmakológus) Pósa Anikó
Pályázati támogatás:	GINOP-2.3.4-15-2016-00002 GINOP
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001-es BibID:	BIBFORM112371
035-os BibID:	(cikkazonosító)1129 (scopus)85160627441 (wos)000994689300001
Első szerző:	Matusovits Danica
Cím:	Paclitaxel Protects against Isoproterenol-Induced Damage in Rat Myocardium : its Heme-Oxygenase Mediated Role in Cardiovascular Research / Matusovits Danica, Murlasits Zsolt, Kupai Krisztina, Baráth Zoltán, Kang Hsu Lin, Osváth Péter, Szűcs Miklós, Priksz Dániel, Juhász Béla, Radák Zsolt, Várkonyi Tamás, Pavo Imre, Pósa Anikó
Dátum:	2023
ISSN:	2076-3921
Megjegyzések:	(1) Background: In cardiovascular applications, paclitaxel inhibits smooth muscle cell proliferation and migration and significantly reduces the occurrence of restenosis and target lesion revascularization. However, the cellular effects of paclitaxel in the myocardium are not well understood; (2) Methods: Wistar rats were divided into four groups: control (CTRL), isoproterenol (ISO) treated (1 mg/kg) and two groups treated with paclitaxel (PAC), which was administrated (10 mg/kg/day) for 5 days by gavage/per os alone or in combination (ISO + PAC) 3 weeks after ISO treatment. Ventricular tissue was harvested 24 h later for measurements of heme oxygenase (HO-1), reduced glutathione (GSH), oxidized glutathione (GSSG), superoxide dismutase (SOD), NF-?B, TNF-? and myeloperoxidase (MPO); (3) Results: HO-1 protein concentration, HO-1 activity, SOD protein concentration and total glutathione significantly decreased in response to ISO treatment. When PAC was administered in conjunction with ISO, HO-1, SOD concentration and total glutathione were not different from control levels. MPO activity, NF-?B concentration and TNF-? protein concentration were significantly increased in the ISO-only group, while the levels of these molecules were restored when PAC was co-administered; (4) Conclusions: Oral administration of PAC can maintain the expression of important antioxidants, anti-inflammatory molecules, HO-1, SOD and GSH, and suppress the production of TNF-?, MPO and NF-?B, which are involved in myocardial damage. The principal component of this cellular defense seems to be the expression of HO-1.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk paclitaxel inflammation cardioprotection
Megjelenés:	Antioxidants. - 12 : 5 (2023), p. 1-13. -
További szerzők:	Murlasits Zsolt Kupai Krisztina Baráth Zoltán (fogorvos) Kang, Hsu Lin Osváth Péter (1982-) (Urológus szakorvos) Szűcs Miklós (1966-) (urológus, andrológus) Priksz Dániel (1989-) (farmakológus) Juhász Béla (1978-) (kísérletes farmakológus) Radák Zsolt Várkonyi Tamás Pávó Imre J. Pósa Anikó
Pályázati támogatás:	ÚNKP-22-5 -SZTE-559 Egyéb GINOP_PLUSZ-2.1.1-21-2022-00083 GINOP
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001-es BibID:	BIBFORM076843
Első szerző:	Varga Csaba (orvos)
Cím:	The Effects of Exercise Training and High Triglyceride Diet in an Estrogen Depleted Rat Model : the Role of the Heme Oxygenase System and Inflammatory Processes in Cardiovascular Risk / Csaba Varga, Médea Veszelka, Krisztina Kupai, Denise Börzsei, Zoltán Deim, Renáta Szabó, Szilvia Török, Dániel Priksz, Rudolf Gesztelyi, Béla Juhász, Zsolt Radák, Anikó Pósa
Dátum:	2018
ISSN:	0363-6135
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of sports science & medicine. - 17 : 4 (2018), p. 580-588. -
További szerzők:	Veszelka Médea Kupai Krisztina Börzsei Denise Deim Zoltán Szabó Renáta Török Szilvia Priksz Dániel (1989-) (farmakológus) Gesztelyi Rudolf (1969-) (kísérletes farmakológus) Juhász Béla (1978-) (kísérletes farmakológus) Radák Zsolt Pósa Anikó
Pályázati támogatás:	UNKP-17-4 ÚNKP GINOP-2.3.2-15-2016-00062 GINOP EFOP-3.6.1-16-2016-00008 EFOP
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