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001-es BibID:	BIBFORM069536
Első szerző:	Nagy Károly (népegészségügyi felügyelő)
Cím:	Distinct penetrance of obesity associated susceptibility alleles in the Hungarian general and Roma populations / Nagy Károly, Fiatal Szilvia, Sándor János, Ádány Róza
Dátum:	2017
ISSN:	1662-4025 1662-4033
Megjegyzések:	Methods: A total of 1152 samples from the Hungarian Roma population and 1743samples from the Hungarian general population were genotyped for 20 single nucleotidepolymorphisms (SNPs) associated with the risk of obesity. Two types of multilocusgenetic risk scores were constructed to estimate the combined effect of selected SNPs.Results: Risk allele frequencies differed significantly between the two populations for11 SNPs, with no enrichment in any of the two study groups. Variants (rs1558902,rs1121980, rs9939609 and rs9941349) in the fat mass and obesity-associated (FTO)gene exhibited strong but ethnicity-independent association with obesity. Genetic risk scores showed stronger associations with obesity in the Roma population comparedwith the Hungarian general population; however, without significant gene-populationinteraction.Conclusion: Differences in obesity prevalence between the Hungarian general andHungarian Roma populations could not be explained by their distinct geneticsusceptibility, rather by ethnicity-related environmental and behavioural factors.Nonetheless, particular gene-environment interactions might contribute to the distinctpenetrance of the obesity-associated genetic factors in populations of different ethnicbackgrounds.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban body mass index FTO gene variants obesity Roma Gypsy genetic risk score
Megjelenés:	Obesity Facts. - 10 : 5 (2017), p. 444-457. -
További szerzők:	Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember) Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
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001-es BibID:	BIBFORM053222
Első szerző:	Nagy Károly (népegészségügyi felügyelő)
Cím:	Evaluation of the genotoxicity of the pyrethroid insecticide phenothrin / Károly Nagy, Gábor Rácz, Takashi Matsumoto, Róza Ádány, Balázs Ádám
Dátum:	2014
ISSN:	1383-5718
Megjegyzések:	Phenothrin, a synthetic pyrethroid compound, is widely used to control agricultural and household insects, as well as to eliminate human louse infestation. Toxicity studies on the direct DNA-damaging effect of phenothrin are lacking. We therefore investigated whether phenothrin exposure can lead to increased DNA damage in vitro in human peripheral blood lymphocytes and in human hepatocytes. Genotoxicity was evaluated by means of the comet assay modified with formamidopyrimidine DNA-glycosylase post-treatment for the detection of oxidative base-damage in DNA. We also assessed the cytotoxic potential of this compound by use of combined fluorescence viability staining. Our results show that phenothrin induces statistically significant, dose-dependent DNA damage in the absence of marked cytotoxicity at concentrations higher than 20 ?M and 50 ?M in human blood peripheral lymphocytes and hepatocytes, respectively. Oxidative DNA damage could also be detected in the two cell types, although this did not reach statistical significance. These findings provide evidence of the DNA-damaging potential of phenothrin and call for additional studies to reveal the genotoxic properties of this pyrethroid. The observations also point at the importance of using caution when considering the use of phenothrin.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban Comet assay Pyrethroid Phenothrin Sumithrin DNA damage
Megjelenés:	Mutation Research-Genetic Toxicology And Environmental Mutagenesis. - 770 (2014), p. 1-5. -
További szerzők:	Rácz Gábor (1982-) (orvos, környezetegészségügyi szakember) Matsumoto, Takashi Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Ádám Balázs (1973-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:	4.2.4. A/2-11-1-2012-0001 Nemzeti Kiválóság Program TÁMOP TÁMOP-4.2.2.A-11/1/KONV-2012-0031 TÁMOP
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001-es BibID:	BIBFORM047732
035-os BibID:	PMID:23907938
Első szerző:	Nagy Károly (népegészségügyi felügyelő)
Cím:	Susceptibility of lung epithelial cells to alkylating genotoxic insult / Károly Nagy, Róza Ádány, Sándor Szűcs, Balázs Ádám
Dátum:	2013
ISSN:	0893-6692
Megjegyzések:	Alkylation is one of the most common types of DNA damage that can lead to mutations and cancer. Lung is the primary target organ of airborne alkylators such as ethylene oxide (EO). However, the ability of EO to cause lung cancer has not been clearly demonstrated yet. The aim of this study was to investigate the susceptibility of lung cells to alkylating DNA insult by detecting EO-mediated DNA damage with the alkaline comet assay in human lung epithelial cells, peripheral blood lymphocytes, and keratinocytes. The susceptibility of these cell types toward the alkylating insult induced by EO was compared against the oxidative DNA insult induced by hydrogen peroxide (H2O2). Due to the volatility of EO, its active concentrations were monitored by gas chromatography during exposure and were found to decrease significantly in a time-dependent manner. EO induced a statistically significant genotoxic effect at the lowest concentration used (16.4 ?M) in lung epithelial cells and in lymphocytes, while in keratinocytes, a genotoxic effect was not detected until 55.5 ?M EO. However, lung epithelial cells demonstrated increased resistance to oxidative insult. In fact, oxidative DNA damage detectable by endonuclease treatment was minimal in lung cells compared with the other cell types. These results suggest an increased sensitivity of lung epithelial cells toward the alkylating effects of EO, which was not observed for oxidative DNA damage. Our findings point out the importance of DNA alkylation and the possible role of EO on the induction of lung cancer.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban comet assay alkylation ethylene oxide oxidative DNA damage
Megjelenés:	Environmental And Molecular Mutagenesis. - 54 : 8 (2013), p. 682-689. -
További szerzők:	Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Szűcs Sándor (1958-) (biokémikus, vegyész) Ádám Balázs (1973-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:	TÁMOP-4.2.2.A-11/1/KONV-2012-0031 TÁMOP
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001-es BibID:	BIBFORM110622
035-os BibID:	(cikkazonosító)5209 (scopus)85151435418 (wos)000957873700001
Első szerző:	Pikó Péter (biológus)
Cím:	Genetic Background of Metabolically Healthy and Unhealthy Obesity Phenotypes in Hungarian Adult Sample Population / Piko Peter, Llanaj Erand, Nagy Karoly, Adany Roza
Dátum:	2023
ISSN:	1422-0067
Megjegyzések:	A specific phenotypic variant of obesity is metabolically healthy (MHO), which is characterized by normal blood pressure and lipid and glucose profiles, in contrast to the metabolically unhealthy variant (MUO). The genetic causes underlying the differences between these phenotypes are not yet clear. This study aims to explore the differences between MHO and MUO and the contribution of genetic factors (single nucleotide polymorphisms?SNPs) in 398 Hungarian adults (81 MHO and 317 MUO). For this investigation, an optimized genetic risk score (oGRS) was calculated using 67 SNPs (related to obesity and to lipid and glucose metabolism). Nineteen SNPs were identified whose combined effect was strongly associated with an increased risk of MUO (OR = 1.77, p < 0.001). Four of them (rs10838687 in MADD, rs693 in APOB, rs1111875 in HHEX, and rs2000813 in LIPG) significantly increased the risk of MUO (OR = 1.76, p < 0.001). Genetic risk groups based on oGRS were significantly associated with the risk of developing MUO at a younger age. We have identified a cluster of SNPs that contribute to the development of the metabolically unhealthy phenotype among Hungarian adults suffering from obesity. Our findings emphasize the significance of considering the combined effect(s) of multiple genes and SNPs in ascertaining cardiometabolic risk in obesity in future genetic screening programs.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk optimized genetic risk score metabolically unhealthy obesity metabolically healthy obesity Hungarian population Lipid metabolism Glucose metabolism
Megjelenés:	International Journal Of Molecular Sciences. - 24 : 6 (2023), p. 1-16. -
További szerzők:	Llanaj, Erand (1988-) (táplálkozási epidemiológus) Nagy Károly (1986-) (népegészségügyi felügyelő) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00005 GINOP
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