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001-es BibID:	BIBFORM074426
035-os BibID:	(WOS)000437726800003 (Scopus)85050336320
Első szerző:	Bencze János (orvos)
Cím:	The melanin-concentrating hormone system in human, rodent and avian brain / Bencze János, Pocsai Krisztina, Murnyák Balázs, Gergely Péter Attila, Juhász Béla, Szilvássy Zoltán, Hortobágyi Tibor
Dátum:	2018
ISSN:	2391-5463
Megjegyzések:	Melanin-concentrating hormone (MCH) is a cyclic 19 amino acid orexigenic hypothalamic peptide. MCH is located in the lateral and dorsal hypothalamus, as well as in the zona incerta. In mammals MCH increases food intake, contributes to regulation of energy balance, temperature, reproductive function, endocrine homeostasis and biological rhythms. Several studies have proved the significance of MCH in obesity, diabetes and depression.Although the peptide is well-characterized in mouse models, much less is known about its functions in avians. In birds the MCH system especially in the lateral and basal hypothalamus has important connections to the limbic system and it coordinates the vegetative and endocrine functions, as well as the emotional behaviour. Pharmacological modulation of MCH system could contribute to the therapy of eating disorders and improve agricultural efficiency regarding avians. Reviewing the current knowledge on MCH system in human, rodents and avians may stimulate a new wave of studies in the field.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Melanin-concentrating hormone (MCH) MCH receptors Neuroanatomy Avians Mammals
Megjelenés:	Open Medicine. - 13 : 1 (2018), p. 264-269. -
További szerzők:	Pocsai Krisztina (1978-) (élettanász) Murnyák Balázs (1986-) (molekuláris biológus, genetikus) Gergely Péter (1974-) (igazságügyi orvosszakértő) Juhász Béla (1978-) (kísérletes farmakológus) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus) Hortobágyi Tibor (1965-) (patológus)
Pályázati támogatás:	EFOP-3.6.3-VEKOP-16-2017-00009 EFOP ÚNKP-17-3 ÚNKP GINOP-2.3.2-15-2016-00043 GINOP 2017-1.2.1-NKP-2017-00002 NKFIH
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001-es BibID:	BIBFORM076676
035-os BibID:	(cikkazonosító)8670398 (WOS)000458978300001 (Scopus)85062331886
Első szerző:	Gergely Péter (igazságügyi orvosszakértő)
Cím:	Tyrosine kinase inhibitor Imatinib mesylate alters DMBA-induced early onco/suppressor-gene expression with tissue-specificity in mice / Péter Attila Gergely, Balázs Murnyák, János Bencze, Andrea Kurucz, Timea Varjas, Katalin Gombos, Tibor Hortobágyi
Dátum:	2019
ISSN:	2314-6133 2314-6141
Megjegyzések:	Tyrosine kinases play crucial roles in cellular development and tumorigenesis. Tyrosine kinase inhibitors (TKIs) are effective and widely-used drug molecules in targeted cancer therapies. Altered expressions of proto-oncogenes and tumor suppressor genes after DMBA (7,12- dimethylbenz[a]anthracene) treatment have been described as early markers of tumor induction, however their tissue-specific effects remain still unclear. Our study was aimed to examine the short-term possible anti-neoplastic and chemo-preventive effects of a TKI compound (imatinib mesylate) on a DMBA-induced mouse tumor model. In addition, we also investigated the tissue specific expressions of Hras, Kras, Myc, Trp53 genes in the brain, bone marrow, spleen, liver, abdominal lymph nodes, thymus, lungs and kidneys, respectively. 24 hours after the imatinib mesylate injection, we observed significant Kras down-regulations in the bone marrow and lung of the DMBA-treated mice. Moreover, the mRNA expression of Myc was also found to be decreased significantly in the spleen. Interestingly, while Trp53 expression was significantly increased in the lung, it was decreased in the other tissues. However, there was also a tendency in the decreased Myc level in the bone marrow, brain, kidneys, lungs, lymph nodes, and in the decreased Hras level in the bone marrow, kidneys and lungs, although no significant differences were observed. Our findings indicate rapid tissue-specific impact of imatinib mesylate on DMBA-induced gene expression in vivo, supporting the chemo-preventive potential of imatinib mesylate in cancer.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	BioMed Research International. - 2019 (2019), p. 1-12. -
További szerzők:	Murnyák Balázs (1986-) (molekuláris biológus, genetikus) Bencze János (1991-) (orvos) Kurucz Andrea (1984-) (orvos) Varjas Tímea Gombos Katalin Hortobágyi Tibor (1965-) (patológus)
Pályázati támogatás:	2017-1.2.1-NKP-2017-00002 Egyéb UNKP-18-3 Egyéb EFOP-3.6.3-VEKOP-16-2017-00009 EFOP
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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