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001-es BibID:	BIBFORM058450
Első szerző:	Vecsernyés Miklós (gyógyszertechnológus, endokrinológus)
Cím:	New aspects of the immunoregulation by the hypothalamo-pituitary-adrenal (HPA) axis / Vecsernyés, M., Kovács, K. J., Tóth, B. E., Welke, L., Nagy, G. M.
Dátum:	2012
Megjegyzések:	One of the basic neuro-immune-endocrine interaction is the hypothalamo-pituitary-adrenal axis (HPA) to harmonize immune response to inflammatory stressors. Immune defense mechanisms mediated by cytokines and other humoral factors play particularly important roles in this communication. They are also potent activators in the CNS and factors of the HPA axis, like an increased secretion of glucocorticoids (GC). They can act as major feedback regulator of the vertebrate immune response via suppression of a wide range of cytokines, as well as interferons. Increases in systemic GC levels, however, often play dual role: do not suppress all cytokines since inhibition of a particular cytokine may result in elevated production of others. External stimuli/acute stress can compromise activation of the HPA axis and activate immune processes for defense, redirecting leukocytes from the circulation to the environment/organism interface. Overall it results in release of danger-associated molecular patterns (DAMPs) to activate cells of the innate immune system, which is resolved by neural, hormonal or immune mechanisms. The chronic stress leads to chronic immune arousal and subsequent sterile, low-grade inflammation, which has been identified in most 'stress-related or 'civilized' disorders in humans. The role of pituitary-gonadal axis in the activation of HPA axis results in a gender difference in HPA response to immunological challenges: e.g. can be varied during the estrus cycle, pregnancy or lactation. That corresponds to the results of recent experimental data that reveals an important role of certain neurotramsitters (such as dopamine) in immune regulation. Internal constitutional-factors of neuro-immune-endocrine interaction, such as corticotropin-releasing hormone (CRH) and its receptors (CRF-R1 and CRF-R2), melanocortin peptides, glucocorticoids or pro-inflammatory cytokines can also act as an immunoregulator, since their receptors is present in lymphoid organs, also in peripheral blood and organs that are enhanced under inflammatory conditions. In spite of series experimental data, the role of CRH and other members of its family, as well as its receptors in inflammation are still controversial. This dual role may be due to different CRF receptors and altered functionality. There are several putative mechanisms or 'ports of entry', in which the cytokines may affect HPA activity and CRH release. Some influences of cytokines on the HPA axis may be exerted by an indirect way. The aim of our review was to summarize and outline of key interacting agents based upon recent experimental results.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Advances in Neuroimmune Biology. - 3 : 3-4 (2012), p. 287-295. -
További szerzők:	Kovács K. J. Tóth B. E. Welke L. Nagy G. M.
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM030666
Első szerző:	Vecsernyés Miklós (gyógyszertechnológus, endokrinológus)
Cím:	Suckling-induced change in oxytocin but not in alpha-MSH concentrations of the median eminence, the neural-, intermediate- and anterior lobes of the pituitary gland / M. Vecsernyés, G. Nagy, L. Mészáros, L. Bodnár, K. W. Ahmed, R. Tóth, J. Julesz, G. M. Nagy
Dátum:	2000
ISSN:	0743-5800
Megjegyzések:	Previous reports have implicated that pituitary-derived prolactin (PRL) is secreted from two distinct zones of mammotropes within the anterior lobe (AL). The inner zone (AL-IZ), located adjacent to the neuro-intermediate lobe (NIL), is supposed to be involved in the rapid and massive discharge of PRL from the pituitary gland due to suckling stimulus. Whereas the outer-zone (AL-OZ) gives the basal secretion and it does not play a role in the acute secretory response during nursing. Anatomically, the AL-IZ has an intimate contact with the NIL because the blood passing through the short portal vessels (SPV) bathes it first. Based on this fact it would be hypothesized that locally released and/or produced compounds, like OXY and alpha-MSH, can be delivered to the AL-IZ. In conjunction, OXY and alpha-MSH have already been implicated to play a role in the regulation of PRL release during suckling. Therefore, the purpose of this study was to examine the possible local transportation of these hormones into the median eminence and various regions of the pituitary gland of lactating rats. We have measured the concentrations of OXY and alpha-MSH from tissue samples of nonsuckled (NS) and 10 or 30 min after suckling (S) was initiated using specific RIAs. It has been shown that there are no changes in the concentration of OXY and alpha-MSH in theAL-IZ and AL-OZ due to suckling stimulus. In contrast, our data provide compelling evidence that OXY is transported into the IL, which can be further increased by suckling stimulus. These data suggest that blood transfusing NL passes through the IL before it is drained into the cavernous sinus, which opens the road for OXY into the general circulation. In addition, our data have unequivocally shown a lack of local delivery of either alpha MSH or OXY into the AL that raises serious doubt about their possible role in PRL secretion during suckling stimulus.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Endocrine Research 26 : 3 (2000), p. 333-345. -
További szerzők:	Nagy G. (Budapest) Mészáros L. Bodnár L. Ahmed, K. W. Tóth R. Julesz János Nagy G. M.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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