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001-es BibID:	BIBFORM030573
035-os BibID:	PMID:9739113 WOS:000076241100010
Első szerző:	DeMaria, Jamie E.
Cím:	The effect of neurointermediate lobe denervation on hypothalamic neuroendocrine dopaminergic neurons / Jamie E. DeMaria, Dora Zelena, Miklós Vecsernyés, György M. Nagy, Marc E. Freeman
Dátum:	1998
ISSN:	0006-8993
Megjegyzések:	The contribution of tuberohypophyseal and periventricular-hypophyseal dopaminergic neurons to the regulation of the secretion of prolactin (PRL) has yet to be clarified. In this study, we used pituitary stalk compression to disrupt hypothalamic neural input to the neurointermediate lobe (NIL). Neurointermediate lobe denervation (NIL-D) selectively disrupts the axons of tuberohypophyseal and periventricular-hypophyseal dopaminergic neurons, while leaving tuberoinfundibular dopaminergic neurons and the vascular supply of the pituitary gland intact. NIL-D was performed in ovariectomized (OVX) rats. The concentration of DA and 3,4-dihydroxyphenylacetic acid (DOPAC) in the median eminence (ME) and various regions of the pituitary gland of OVX and OVX+NIL-D rats were measured by HPLC-EC. The concentration of PRL, alpha-melanocyte stimulating hormone (alpha-MSH), and luteinizing hormone (LH) in serum were determined by radioimmunoassay. Successful NIL-D was confirmed by increased water intake. One week after NIL-D, serum PRL and alpha-MSH were elevated, but there was no change in the concentration of LH in serum. The concentration of DA was increased in the median eminence (ME), decreased in the outer zone of the anterior lobe (AL-OZ), as well as the intermediate (IL) and neural lobes (NL), and remained unchanged in the inner zone of the anterior lobe (AL-IZ). The concentration of DOPAC was increased in the ME and NL, decreased in the IL, and remained unchanged in both the AL-IZ and AL-OZ. These data confirm that pituitary stalk compression denervates the NIL. Moreover, decreases in the concentration of DA in the IL and AL-OZ, coupled with elevation of serum PRL and alpha-MSH indicate that DA from the NIL contributes to the increased inhibition of the secretion of PRL and alpha-MSH in OVX rats.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban dopamine DOPAC neurointermediate lobe denervation prolactin egyetemen (Magyarországon) készült közlemény
Megjelenés:	Brain Research 806 : 1 (1998), p. 89-94. -
További szerzők:	Zelena Dóra Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Nagy György M. Freeman, Marc E.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM031973
Első szerző:	Tóth E. Béla (orvos)
Cím:	Salsolinol is putative endogenous Neuro-intermediate lobe prolactin-releasing factor / Tóth B. E., Homicskó K., Radnai B., Maruyama W., DeMaria J. E., Vecsernyés M., Fekete M. I. K., Fülöp F., Naoi M., Freeman M. E., Nagy G. M.
Dátum:	2001
ISSN:	0953-8194
Megjegyzések:	The isolation and identification of a prolactin-releasing factor (PRF) from the neuro-intermediate lobe of the pituitary gland has been pursued for over a decade. Using high-pressure liquid chromatography with electrochemical detection (HPLC-ECD) and gas chromatography/mass spectrometry (GC/MS) (R)-salsolinol (SAL) (a dopamine-related stereo-specific tetrahydroisoquinoline) was found to be present in neuro-intermediate lobe as well as median eminence extracts of male, intact-, and ovariectomized female rats. Moreover, analysis of SAL concentrations in neuro-intermediate lobe revealed parallel increases with plasma prolactin in lactating rats exposed to a brief (10 min) suckling stimulus following 4-h separation. SAL appears to be a selective and potent stimulator of prolactin secretion in vivo and it was without effect on the secretion of other pituitary hormones. We have also found that SAL can elevate prolactin release, although to a lesser extent, in pituitary cell cultures as well as in hypophysectomized rats bearing anterior lobe transplants under the kidney capsule. Lack of interference of SAL with [3H]-spiperone binding to AP homogenates indicates that SAL does not act at the dopamine D2 receptor. Moreover, [3H]-SAL binds specifically to homogenate of AL as well as neuro-intermediate lobe obtained from lactating rats. Taken together, our data clearly suggest that SAL is synthesized in situ and this compound can play a role in the regulation of pituitary prolactin secretion.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal Of Neuroendocrinology 13 : 12 (2001), p. 1042-1050. -
További szerzők:	Homicskó Krisztián Gy. Radnai Balázs Maruyama W. DeMaria, Jamie E. Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Fekete I. K. Márton Fülöp Ferenc Naoi, M. Freeman, Marc E. Nagy György M.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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