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1.

001-es BibID:BIBFORM030625
Első szerző:Bodnár Ibolya
Cím:Effect of neonatal treatment with monosodium glutamate on dopaminergic and L-DOPA-ergic neurons of the medial basal hypothalamus and on prolactin and MSH secretion of rats / Ibolya Bodnár, Pál Göőz, Hitoshi Okamura, Béla E. Tóth, Miklós Vecsernyés, Béla Halász, György M. Nagy
Dátum:2001
ISSN:0361-9230
Megjegyzések:The effect of neonatal treatment with monosodium L-glutamate (MSG) on the dopaminergic systems of the medial basal hypothalamus has been investigated using tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) immunocytochemistry. Changes in plasma levels of prolactin (PRL) and alpha-melanocyte-stimulating hormone (MSH) have also been determined in intact and in MSG-treated rats after inhibition of TH by alpha-methyl-p-tyrosine (alpha-MpT) or without inhibition of enzyme activity. Monosodium glutamate resulted in a 40% reduction in the number of TH immunopositive tuberoinfundibular neurons, but no change in the number of AADC-positive tuberoinfundibular nerve cells, indicating that this reduction has occurred mainly in TH-positive but AADC-negative elements, i.e., in L-DOPA-ergic neurons. In contrast, MSG did not cause changes in the number of TH and AADC immunoreactive neurons of the periventriculohypophysial and tuberohypophysial dopaminergic systems, and it did not influence basal plasma PRL levels. alpha-methyl-p-tyrosine has increased plasma PRL concentrations in both control and MSG-treated rats of both sexes, but significantly higher responses were detected in females. None of the treatments had any effect on plasma MSH level. These findings suggest that MSG affects primarily L-DOPA-ergic neurons located in the ventrolateral part of the arcuate nucleus, but not dopaminergic neurons situated in the dorsomedial part of the arcuate nucleus; neither PRL nor MSH secretion is altered by MSG; a significant sex difference exists in the pituitary PRL response to inhibition of TH, and this response is not affected by MSG.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
arcuate nucleus
tyrosine hydroxylase
aromatic L-amino acid decarboxylase
immunocytochemistry
Megjelenés:Brain Research Bulletin 55 : 6 (2001), p. 767-774. -
További szerzők:Göőz Pál Okamura, Hitoshi Tóth E. Béla (1960-) (orvos) Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Halász Béla Nagy György M.
Pályázati támogatás:T-30748
OTKA
T-029004
OTKA
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DOI
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2.

001-es BibID:BIBFORM066180
035-os BibID:(cikkazonosító)GP121
Első szerző:Nagy György M.
Cím:Expression of dopamine (DA) D2 receptors (D2R) in corticotroph cells is responsible for the switch of hypothalamic regulation of ACTH secretion to DA in lactating rats / György M. Nagy, Pálma Fehér, Ibolya Bodnár, Reid Luke, Zsuzsanna E. Tóth, Miklós Vecsernyés, Béla E. Tóth
Dátum:2016
ISSN:1470-3947 1479-6848
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok poszter
folyóiratcikk
Megjelenés:Endocrine Abstracts. - 41 (2016), p. 1. -
További szerzők:Fehér Pálma (1976-) (gyógyszerész) Bodnár Ibolya Luke, Reid Tóth Zsuzsanna (1977-) (kardiológus) Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Tóth E. Béla (1960-) (orvos)
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM073665
Első szerző:Oláh Márk
Cím:Role of salsolinol in the regulation of pituitary prolactin and peripheral dopamine release / Márk Oláh, Ibolya Bodnár, Galit Daniel, Béla E. Tóth, Miklós Vecsernyés, György M. Nagy
Dátum:2011
ISSN:1445-5781 1447-0578
Megjegyzések:(R)?Salsolinol (SAL), a dopamine (DA)?related tetrahydroisoquinoline, has been found in extracts of the neuro?intermediate lobes (NIL) of pituitary glands and in the median eminence of the hypothalamus obtained from intact male rats and from ovariectomized and lactating female rats. Moreover, analysis of SAL concentrations in NIL revealed parallel increases with plasma prolactin (PRL) in lactating rats exposed to a brief (10 min) suckling stimulus after 4?h separation. SAL is sufficiently potent in vivo to account for the massive discharge of PRL that occurs after physiological stimuli (i.e. suckling). At the same time, it was without effect on the secretion of other pituitary hormones. It has been also shown that another isoquinoline derivative, 1?methyldihydroisoquinoline (1MeDIQ), which is a structural analogue of SAL, can dose?dependently inhibit the in?vivo PRL?releasing effect of SAL. Moreover, 1MeDIQ can inhibit the elevation of plasma PRL induced by physiological stimuli, for example suckling, or in different stressful situations also. 1MeDIQ also has a psycho?stimulant action, which is fairly similar to the effect of amphetamine, i.e. it induces an increase in plasma catecholamine concentrations. It is clear from these data that this newly discovered endogenous compound could be involved in regulation of pituitary PRL secretion. It has also been observed that SAL is present in peripheral, sympathetically innervated organs, for example the atrium, spleen, liver, ovaries, vas deferens, and salivary gland. Furthermore, SAL treatment of rats results in dose?dependent and time?dependent depletion of the DA content of the organs listed above without having any effect on the concentration of norepinephrine. More importantly, this effect of SAL can be completely prevented by amphetamine and by 1MeDIQ pretreatment. It is clear there is a mutual interaction between SAL, 1MeDIQ, and amphetamine or alcohol, not only on PRL release; their interaction with catecholamine "synthesis/metabolism" of sympathetic nerve terminals is also obvious.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Reproductive Medicine and Biology 10 : 3 (2011), p. 143-151. -
További szerzők:Bodnár Ibolya Daniel, Galit Tóth E. Béla (1960-) (orvos) Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Nagy György M.
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM073662
Első szerző:Reinhoffer Viktória
Cím:The Regulation of Pituitary Prolactin Secretion : Hypothalamic, Intrapituitary and Intracellular Factors and Signaling Mechanisms / Viktória Reinhoffer, Márk Oláh, Miklós Vecsernyés, Béla E. Tóth, György M. Nagy
Dátum:2013
ISBN:978 953 51 0943 3
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok könyvfejezet
Megjelenés:Prolactin / Nagy M. György, Tóth E. Béla. - p. 167-194. -
További szerzők:Oláh Márk Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Tóth E. Béla (1960-) (orvos) Nagy György M.
Pályázati támogatás:OTKA-81522
OTKA
TÁMOP-4.2.2.A-11/1/KONV-2012-0025
TÁMOP
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM103786
Első szerző:Tóth E. Béla (orvos)
Cím:Klinikai vizsgálatok értékelése az alkalmazott d-vitamin terápia az elesési- és a csonttörési kockázat tekintetében = Risk of falls and fractures associated with vitamin D therapies in scope of clinical rials / Tóth E. Béla, Mirani Sara, Horváth László, Tóth Áron, Vecsernyés Miklós
Dátum:2020
ISSN:0001-6659
Megjegyzések:Background Scientific and clinical evidences documented that vitamin D is essential to maintain calcium absorption and consequently the normal funtion of the musculoskeletal system in human. The deficiency is rather endemic due to significant Vitamin D deficiency detected among most of population. Clinical trial data over the past decades clearly support the skeletal benefits of vitamin D supplementation in patients with circulating 25OHD levels of less than 30 nmol/L. The role of vitammin D supplementation has been establashed for the indication also in prevention to minimize the risk of falls and fractures in general. However, the use of bolus or high-dose vitamin D supplementation in clinical trials among elderly people shown unexpeced adverse drug reactions and the need for further surveillance in dosing specifications of vitamin D therapies. Aims An overall goal is to establish the safety specificiaction of vitamin D supplementation for prevention and also in various medical conditions in order to minimise the risk of falls and fractures in elderly population. Additionally, to identify the risks associated with the most relevant life-style factors and nutritional conditions that may interfere with the success of vitamin D supplementation applied for prevenetion in general. Methods The results of clinical trials based on observational studies at clinical facilities and supported by survey in general public focused on alimentary, solar exposition, the use of dietary- and food supplementation but also assessed the edherence to given medications and other life-style factors. Results VItamin D supplementation is indicated below 75 nmol/L, which is almost 90% of population among elderly and approx. 65-70% in general for the mass of population. The risk of fractures are significantly higher among patients with low 25OHD levels (OR 2.83; CL 1.51-5.31, p=0.007). But over 25% of population is not adherent to prescribed OP therapies. Alimenentary and life-style conditions are both needed optimal skeletal health: two-thirds of the subjects are underestimated their daily calcium intake, although only less then 30% of them are aware of the importance of calcium intake. Moreover, the physical activity level is being adequate in case of 28% even among the younger population. Conclusion The option of loading plus maintenance dose schedule proven to be efficient in cases of significant Vitamin D deficiency, however with proper nutritional and life-style conditions only in reduction of risk of falls and fractures.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok poszter
folyóiratcikk
Megjelenés:Acta Pharmaceutica Hungarica. - 90 : 2-3 (2020), p. 187. -
További szerzők:Mirani, Sara (1978-) (Phd hallgató) Horváth László (1973-) (gyógyszerész) Tóth Áron (1987-) (mérnök informatikus) Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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6.

001-es BibID:BIBFORM043888
Első szerző:Tóth E. Béla (orvos)
Cím:Role of Peripheral and Brain-Derived Dopamine (DA) in Immune Regulation / Béla E. Tóth, Miklós Vecsernyés, Tivadar Zelles, Kristóf Kádár, György M. Nagy
Dátum:2012
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Advances in Neuroimmune Biology. - 2 (2012), p. 111-155. -
További szerzők:Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Zelles Tivadar Kádár Kristóf Nagy György M.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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7.

001-es BibID:BIBFORM031973
Első szerző:Tóth E. Béla (orvos)
Cím:Salsolinol is putative endogenous Neuro-intermediate lobe prolactin-releasing factor / Tóth B. E., Homicskó K., Radnai B., Maruyama W., DeMaria J. E., Vecsernyés M., Fekete M. I. K., Fülöp F., Naoi M., Freeman M. E., Nagy G. M.
Dátum:2001
ISSN:0953-8194
Megjegyzések:The isolation and identification of a prolactin-releasing factor (PRF) from the neuro-intermediate lobe of the pituitary gland has been pursued for over a decade. Using high-pressure liquid chromatography with electrochemical detection (HPLC-ECD) and gas chromatography/mass spectrometry (GC/MS) (R)-salsolinol (SAL) (a dopamine-related stereo-specific tetrahydroisoquinoline) was found to be present in neuro-intermediate lobe as well as median eminence extracts of male, intact-, and ovariectomized female rats. Moreover, analysis of SAL concentrations in neuro-intermediate lobe revealed parallel increases with plasma prolactin in lactating rats exposed to a brief (10 min) suckling stimulus following 4-h separation. SAL appears to be a selective and potent stimulator of prolactin secretion in vivo and it was without effect on the secretion of other pituitary hormones. We have also found that SAL can elevate prolactin release, although to a lesser extent, in pituitary cell cultures as well as in hypophysectomized rats bearing anterior lobe transplants under the kidney capsule. Lack of interference of SAL with [3H]-spiperone binding to AP homogenates indicates that SAL does not act at the dopamine D2 receptor. Moreover, [3H]-SAL binds specifically to homogenate of AL as well as neuro-intermediate lobe obtained from lactating rats. Taken together, our data clearly suggest that SAL is synthesized in situ and this compound can play a role in the regulation of pituitary prolactin secretion.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Neuroendocrinology 13 : 12 (2001), p. 1042-1050. -
További szerzők:Homicskó Krisztián Gy. Radnai Balázs Maruyama W. DeMaria, Jamie E. Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Fekete I. K. Márton Fülöp Ferenc Naoi, M. Freeman, Marc E. Nagy György M.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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8.

001-es BibID:BIBFORM031998
035-os BibID:PMID:9227842 WOS:A1997XH42600010
Első szerző:Vecsernyés Miklós (gyógyszertechnológus, endokrinológus)
Cím:Effect of posterior pituitary denervation (PPD) on prolactin (PRL) and alpha-melanocyte-stimulating hormone (alpha-MSH) secretion of lactating rats / Miklós Vecsernyes, Krisztina Krempels, Béla E. Toth, János Julesz, Gábor B. Makara, György M. Nagy
Dátum:1997
Megjegyzések:Previous data have clearly suggested that the posterior pituitary (PP), consisting of neural lobe (NL) and intermediate lobe (IL), has a role in the control of anterior pituitary PRL secretion. However, basic aspects of this regulatory mechanism like (1), the role of an intact hypothalamic innervation of the PP as well as (2) the site of production of previously found PRL releasing substance(s) have not yet been characterized. Denervation of the PP (PPD) is an effective method for having a selective lesion of the innervation of PP, indeed, PPD results in a disappearance of neurosecretory materials from NL and tyrosine hydroxylase (TH) immunoreactivity from IL, leaving blood supply of all three lobes intact. Blood samples were taken from freely moving sham an PP-denervated lactating rats before and after 4-h separation from their pups and during the suckling stimulus. PPD blocks separation-induced depletion but only attenuates suckling induced release of PRL. Furthermore, it doubles plasma level of alpha-MSH during the entire sampling period, which has been used as a marker for in vivo secretory activity of IL cells. Lack of the separation-induced depression in plasma PRL of PPD animals can be partially restored by normalizing the diabetes insipidus with treatment of a vasopressin analogue, 1-desamino-8-D-arginine-vasopressin (dDAVP). In contrast, dDAVP, neither alone nor in combination with oxytocin (OXY), can change PPD-induced elevation of plasma alpha-MSH as well as attenuation of PRL response induced by suckling. It is concluded that: (1) contribution of the THDA system parallel to the confirmed role in the regulation of alpha-MSH seems to be crucial for the depletion of plasma PRL induced by separation but not for the elevation due to suckling stimulus, (2) intact hypothalamic innervations of both NL and IL, regulating water intake and the secretion of alpha-MSH, respectively, are necessary for normal secretory responses of AL during lactation, (3) as well as for the presence of PRF activity in PP, (4) which does not solely responsible for suckling-induced PRL release. Therefore, an interplay between several substances produced by NIL of the pituitary gland must have been responsible for the intact regulation of PRL secretion during lactation.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Posterior pituitary denervation
Prolactin
a-MSH
Lactating rats
Megjelenés:Brain Research Bulletin 43 : 3 (1997), p. 313-319. -
További szerzők:Krempels Krisztina Tóth E. Béla (1960-) (orvos) Julesz János Makara Gábor B. Nagy György M.
Pályázati támogatás:13055
OTKA
20916
OTKA
2922
OTKA
16827
OTKA
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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