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001-es BibID:	BIBFORM087278
035-os BibID:	(WoS)000492444403175
Első szerző:	Képes Zita (orvos)
Cím:	Examinantion of brain perfusion and metabolism in metabolic diseases (focusing on diabetes and obesity) / Zita Képes, J. Varga, F. Nagy, M. Emri, M. Káplár, Cs. Aranyi, I. Garai
Dátum:	2019
ISSN:	1619-7070 1619-7089
Megjegyzések:	Aim/Introduction: Microcircular alterations that could already be observed in prediabetic state (obesity and insulin resistance) are supposed to have significant role in the developement of the consequences of diabetes mellitus. The main aim of our study was to compare the cerebrovascular microcirculation and metabolism of obese patients and patients suffering from type 2 diabetes mellitus. Materials and Methods: In our prospective study 57 patients with controlled type 2 diabetes mellitus (52?9,6 years) and 46 obese patients (50,6?7,9 years) were enrolled. BMI proved to be 34,06?5,94 in the diabetic group while it was 38,14?6,06 among the obese patients. Dynamic Tc99m-HMPAO study (AnyScanFlex, Mediso) was performed for evaluation of hemispheral perfusion using Patlak analysis. Then tomographic imaging was carried out at rest condition. Brain metabolism was estimated applying 18F-FDG PET/CT (AnyScan PC, Mediso). FDG and HMPAO scans were transformed to MNI152 brain map after T1 registration and used for SPM (Statistical Parametric Mapping) analysis. NeuroQ application (Syntermed) was used to evaluate regional differences. Statistical analysis (Shapiro-Wilk, Wilcoxon, Spearman correlation) was applied for assessment of group differences. Results: Hemispheral perfusion calculated with Patlak analysis showed positive correlation with BMI (rho=0.35, p=0.016). There were no significant differences in hemispheral and regional perfusion in T2DM and the obese group. However, we found hypometabolism in right and left cuneus (Br17) in T2DM with SPM analysis. NeuroQ analysis did not reveal significant regional perfusion or metabolic defects in either groups. Conclusion: Based on current literature hypometabolism in the region of the cuneus is a characteristic feature of neurodegenerative diseases. The reason why no significant perfusion defects were found could be explained by the fact that the enrolled diabetics were therapeutically well managed. Unexpected significant correlation with BMI is unclear, further investigation is required. References: None
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt folyóiratcikk
Megjelenés:	European Journal of Nuclear Medicine and Molecular Imaging. - 46 : S1 (2019), p. S399-S400. -
További szerzők:	Varga József (1955-) (fizikus) Nagy Ferenc (1984-) (fizikus) Emri Miklós (1962-) (fizikus) Káplár Miklós (1965-) (belgyógyász, diabetológus) Aranyi Sándor Csaba (1988-) (programtervező informatikus) Garai Ildikó (1966-) (radiológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM087279
035-os BibID:	(WoS)000492444401187
Első szerző:	Mikó Márton
Cím:	Alterations of peripherial micorcirculation in Diabetes mellitus and Obesity / M. Mikó, J. Varga, F. Nagy, M. Emri, M. Káplár, A. Forgács, I. Garai
Dátum:	2019
ISSN:	1619-7070 1619-7089
Megjegyzések:	Aim/Introduction: The number of people with obesity and diabetes is continously growing. These are important metabolic drivers of cerebrovascular and cardiovascular diseases as well as peripheral neuropathy. Damage to the microcirculation is the basis for these conditions.In our study we investigated peripheral perfusion in these two metabolic diseases and its correlation with laboratory parameters and neuropathy. Materials and Methods: In this prospective study, 57 patients with controlled type 2 diabetes mellitus (T2DM) (mean age:52?9.6) and 46 patients with obesity (50.6?7.9) were recruited. BMI was 34.1?5.9 in T2DM and 38.1?6.1 in the obese group. Quantitative Tc99m HMPAO (Mediradiopharma, Hungary) SPECT/CT (AnyscanFlexSC, Mediso, Hungary) studies were performed to assess peripheral microcirculation in the legs. Patients with known symptomatic peripheral circulation abnormalities were excluded from the study. For the SUVmean calculation, fixed sized spheric VOIs (volume of interest) were drawn in the calf musculature bilaterally. Neurometer testing (NM-01/CPT) was used for evaluating sub-clinical peripheral nerve dysfunction. For statistical analysis, Shapiro normality test, Wilcoxon test and paired Spearman correlation was done. Results: There were no significant differences of calculated SUVmean values in right and left legs in both groups, neither were there any in neurometer testing. However, leg perfusion was significantly lower in the diabetic group predominantly on the left side (p=0.015 right leg, p=0,00065 left leg). Neurometer data showed correlation with HBA1C in the diabetic group, but none with leg perfusion. There was no correlation between neurometer test results and leg perfusion in the obese group. We also investigated the correlation of BMI, age and leg perfusion. BMI showed positive correlation with mean leg perfusion (rho=0,36, p=0,001) and no correlation with age was found. Conclusion: Quantitative leg perfusion SPECT/CT with Tc99m HMPAO is a sensitive method for evaluating subclinical perfusion abnormalities, providing complementary information for early assessment of peripheral neuropathy in diabetes. Further investigation is needed to understand the background of correlation of leg perfusion and BMI. References: None
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt folyóiratcikk
Megjelenés:	European Journal of Nuclear Medicine and Molecular Imaging. - 46 : S1 (2019), p. S204-S205. -
További szerzők:	Varga József (1955-) (fizikus) Nagy Ferenc (1984-) (fizikus) Emri Miklós (1962-) (fizikus) Káplár Miklós (1965-) (belgyógyász, diabetológus) Forgács Attila (1985-) (fizikus) Garai Ildikó (1966-) (radiológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
Borító:
Saját polcon: